The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
A New View into the Regulation of Purine Metabolism: The Purinosome
Open accessAbstract
Other than serving as building blocks for DNA and RNA, purines metabolites provide a cell with the necessary energy and cofactors to promote cell survival and proliferation. A renewed interest in how purine metabolism may fuel cancer progression has uncovered a new perspective into how a cell regulates purine need. Under cellular conditions of high purine demand, the de novo purine biosynthetic enzymes cluster near mitochondria and microtubules to form dynamic multi-enzyme complexes referred to as purinosomes. This review highlights the purinosome as a novel level of metabolic organization of enzymes in cells, its consequences for regulation of purine metabolism, and the extent that purine metabolism is being targeted for the treatment of cancers.
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Citations
Cites
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InfluentialmTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
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InfluentialMetabolic Reprogramming: the Emerging Concept and Associated Therapeutic Strategies
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InfluentialSelf-citationTracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
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Cited by
Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
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De novo and salvage purine synthesis pathways across tissues and tumors
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Regulatory mechanisms of one-carbon metabolism enzymes
Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105457 · Cited by 103
A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight
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Metadata
- Authors
- Pedley, A. M., & Benkovic, S. J.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 42
- Issue
- 2
- Pages
- 141-154
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2540503396
- Cited by
- 576
- References
- 14
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
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