The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Lactate: A Metabolic Driver in the Tumour Landscape
Abstract
The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
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Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid
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Glucose feeds the TCA cycle via circulating lactate
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The Science and Translation of Lactate Shuttle Theory
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Cited by
Lactate metabolism in human health and disease
Li, X., Yang, Y., Zhang, B., Lin, X., Fu, X., An, Y., Zou, Y., Wang, J.-X., Wang, Z., & Yu, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01151-3 · Cited by 1,454
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
Lactate modulation of immune responses in inflammatory versus tumour microenvironments
Certo, M., Tsai, C.-H., Pucino, V., Ho, P.-C., & Mauro, C. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-0406-2 · Cited by 924
Xiong, J., He, J., Zhu, J., Pan, J., Liao, W., Ye, H., Wang, H., Song, Y., Du, Y., Cui, B., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.02.033 · Cited by 804
Lactate in the tumour microenvironment: From immune modulation to therapy
Wang, Z.-H., Peng, W.-B., Zhang, P., Yang, X.-P., & Zhou, Q. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103627 · Cited by 528
Metadata
- Authors
- Ippolito, L., Morandi, A., Giannoni, E., & Chiarugi, P.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 44
- Issue
- 2
- Pages
- 153-166
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2901951820
- Cited by
- 523
- References
- 96
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
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