The DOI matches its Crossref record; 134 of the 137 references it cites were found in a registry or an index.
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Open accessAbstract
Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
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“The target specificity and toxicity to non-senescent cells is still a big hurdle for clinical applications of the current senolyitc treatments.14,15”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [14]
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Cites
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BackgroundA biomarker that identifies senescent human cells in culture and in aging skin in vivo.
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BackgroundClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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Self-citationCellular Senescence: Defining a Path Forward
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Hallmarks of Cellular Senescence
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“Further, senescent cells can develop structural changes, including an enlarged and flattened morphology, altered composition of the plasma membrane, accumulation of lysosomes and mitochondria, and a remarkable nuclear expansion [17] (Figure 2).”
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BackgroundSelf-citation
Cited by
Sorted by citations
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
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Self-citationBao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
Self-citationAging of the cells: Insight into cellular senescence and detection Methods.
Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287
Metadata
- Authors
- Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y.
- Affiliations
- Binzhou Medical University (CN)
- Imperial College London (GB)
- Mayo Clinic (US)
- Corresponding author
- Sun, Yu
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 45
- Issue
- 7
- Pages
- 578-592
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC7649645
- OpenAlex
- W3014969606
- Cited by
- 195
- References
- 137
- Citations by year
- 2026: 23 · 2025: 27 · 2024: 30 · 2023: 30 · 2022: 40 · 2021: 39 · 2020: 6
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (P01 AG062413, R37-AG013925)
- Cancer Research UK (A12011)
- National Key Research and Development Program of China Stem Cell and Translational Research (2016YFC1302400)
- Breast Cancer Now (2012MayPR070, 2012NovPhD016)
- National Institute for Health Research
- Mayo Clinic
- National Key Research and Development Program of China
- Noaber Foundation
- U.S. Department of Defense (PC111703)
- National Natural Science Foundation of China (31871380, 81472709, 31671425)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, age-related diseases, senolytics, senolytic therapy, healthspan extension, chronic disease, geriatrics, neurodegeneration, cardiovascular disease, cancer
- MeSH terms
- Humans, Neoplasms, Phenotype, Cellular Senescence, Neurodegenerative Diseases
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