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Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
Open accessAbstract
Aging is a major risk factor for numerous human pathologies, including cardiovascular, metabolic, musculoskeletal, and neurodegenerative conditions and various malignancies. While our understanding of aging is far from complete, recent advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-related disorders. Cellular senescence is physiologically beneficial in several contexts, but it has causal roles in multiple chronic diseases. New studies have illustrated the promising feasibility and safety to selectively ablate senescent cells from tissues, a therapeutic modality that holds potential for treating multiple chronic pathologies and extending human healthspan. Here, we review molecular links between cellular senescence and age-associated complications and highlight novel therapeutic avenues that may be exploited to target senescent cells in future geriatric medicine.
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“The target specificity and toxicity to non-senescent cells is still a big hurdle for clinical applications of the current senolyitc treatments.14,15”
From Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators (2024) · cites this paper as [14]
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BackgroundInfluentialFisetin is a senotherapeutic that extends health and lifespan
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BackgroundMitochondria are required for pro-ageing features of the senescent phenotype
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Background
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- Authors
- Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y.
- Affiliations
- Binzhou Medical University (CN)
- Imperial College London (GB)
- Mayo Clinic (US)
- Corresponding author
- Sun, Yu
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 45
- Issue
- 7
- Pages
- 578-592
- ISSN
- 0968-0004 (ISSN-L)
- PMC
- PMC7649645
- OpenAlex
- W3014969606
- Cited by
- 195
- References
- 137
- Citations by year
- 2026: 23 · 2025: 27 · 2024: 30 · 2023: 30 · 2022: 40 · 2021: 39 · 2020: 6
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (P01 AG062413, R37-AG013925)
- Cancer Research UK (A12011)
- National Key Research and Development Program of China Stem Cell and Translational Research (2016YFC1302400)
- Breast Cancer Now (2012MayPR070, 2012NovPhD016)
- National Institute for Health Research
- Mayo Clinic
- National Key Research and Development Program of China
- Noaber Foundation
- U.S. Department of Defense (PC111703)
- National Natural Science Foundation of China (31871380, 81472709, 31671425)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, aging, age-related diseases, senolytics, senolytic therapy, healthspan extension, chronic disease, geriatrics, neurodegeneration, cardiovascular disease, cancer
- MeSH terms
- Humans, Neoplasms, Phenotype, Cellular Senescence, Neurodegenerative Diseases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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