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Reductive Dehalogenases Come of Age in Biological Destruction of Organohalides

Jugder, Bat-Erdene, Ertan, Haluk, Lee, Matthew, Manefield, Michael, Marquis, Christopher P.·2015·Trends in Biotechnology

Abstract

Halogenated organic compounds (organohalides) are globally prevalent, recalcitrant toxic, and carcinogenic environmental pollutants. Select microorganisms encode enzymes known as reductive dehalogenases (EC 1.97.1.8) that catalyze reductive dehalogenation reactions resulting in the generation of lesser-halogenated compounds that may be less toxic and more biodegradable. Recent breakthroughs in enzyme structure determination, elucidation of the mechanisms of reductive dehalogenation, and in heterologous expression of functional reductive dehalogenase enzymes have substantially increased our understanding of this fascinating class of enzymes. This knowledge has created opportunities for more versatile (in situ and ex situ) biologically-mediated organohalide destruction strategies.

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Authors
Jugder, B.-E., Ertan, H., Lee, M., Manefield, M., & Marquis, C. P.
Venue
Trends in Biotechnology
Publisher
Elsevier BV
Published
2015-10
Volume
33
Issue
10
Pages
595-610
ISSN
0167-7799
Cited by
120
References
0
Language
en

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