The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural basis for organohalide respiration
Abstract
How bacteria break down organohalides: Anaerobic bacteria can break down a range of organohalide pollutants. To do so, they use unusual reductive dehalogenase enzymes that remove the halogen ion from the molecule, making the pollutants less toxic. Bommer et al. describe x-ray crystal structures of one such enzyme from Sulfurospirillum multivorans (see the Perspective by Edwards). Vitamin B 12 , present near the substrate binding site, catalyzes the reduction of trichloroethylene in concert with two iron-sulfur clusters. The structures provide mechanistic clues for how to engineer enzymes to recognize other pollutants. Science , this issue p. 455 ; see also p. 424
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“T7RdhA was identified as a corrinoid iron-sulfur protein that employs a norpseudo-B12 cofactor and two Fe4S4 iron-sulfur clusters for catalytic activity (106), through AlphaFold2 modeling and experiments.”
From Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances (2024) · cites this paper as [106]
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Towards automated crystallographic structure refinement with phenix.refine
Afonine, P. V., Grosse-Kunstleve, R. W., Echols, N., Headd, J. J., Moriarty, N. W., Mustyakimov, M., Terwilliger, T. C., Urzhumtsev, A., Zwart, P. H., & Adams, P. D. (2012) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444912001308 · Cited by 5,511
Linking Crystallographic Model and Data Quality
Karplus, P. A., & Diederichs, K. (2012) · Science · doi:10.1126/science.1218231 · Cited by 1,781
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Hu, M., & Scott, C. (2024) · Applied and Environmental Microbiology · doi:10.1128/aem.00157-24 · Cited by 63
Metadata
- Authors
- Bommer, M., Kunze, C., Fesseler, J., Schubert, T., Diekert, G., & Dobbek, H.
- Affiliations
- Institut für Biologie, Strukturbiologie/Biochemie, Humboldt-Universität zu Berlin, Unter den Linden 6, 10099 Berlin, Germany.
- Institut für Mikrobiologie, Friedrich-Schiller-Universität Jena, Lehrstuhl für Angewandte und Ökologische Mikrobiologie, Philosophenweg 12, 07743 Jena, Germany.
- Venue
- Science
- Published
- 2014-10-24
- Volume
- 346
- Issue
- 6208
- Pages
- 455-458
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 268
- References
- 2
- Language
- en
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