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Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes
Abstract
Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the early diagnosis and therapeutic response evaluation of cancer. Here, we review recent advances in biosensors for the detection of cancer-derived exosomes. We discuss the potential exosomal biomarkers of various cancers, which can be applied as indicative targets in the design of biosensors. We further describe the fabrication of exosome detection biosensors with respect to biological recognition strategies and signal transduction techniques, which involve integrated scientific and technological aspects of analytical chemistry and nanotechnology. Furthermore, future research directions and challenges in using cancer-derived exosomes for point-of-care (POC) testing are presented.
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Correspondence - Tranexamic acid for traumatic brain injury
(2005) · London School of Economics and Political Science Theses Online (London School of Economics and Political Science) · doi:10.1016/s0140-6736 · Cited by 11,894
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
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Metadata
- Authors
- Cheng, N., Du, D., Wang, X., Liu, D., Xu, W., Luo, Y., & Lin, Y.
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 37
- Issue
- 11
- Pages
- 1236-1254
- ISSN
- 0167-7799 (ISSN-L)
- OpenAlex
- W2946257502
- Cited by
- 207
- References
- 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cheng, N., Du, D., Wang, X., Liu, D., Xu, W., Luo, Y., & Lin, Y. (2019). Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2019.04.008
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