The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Metal–Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay
Abstract
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly biosensors for convenient, sensitive, and quantitative exosome assay. Herein, we developed a simple and cost-efficient electrochemical biosensor by combining a metal–organic framework (MOF)-functionalized paper and a screen-printed electrode (SPE) for portable, ultrasensitive, and quantitative determination of cancer-derived exosomes. In principle, the biosensor relied on recognition of the exosome by Zr-MOFs and aptamer to initiate the hybridization chain reaction (HCR) and the formation of DNAzyme for signal amplification. Benefiting from the high signal amplification ability of HCR, the label-free paper-based biosensor is capable of ultrasensitive exosome assay with a detection limit down to 5 × 10 3 particles/mL, which is superior to that of most reported methods. Moreover, the proposed paper-based biosensor possessed the advantages of low cost, simple operation, and high sensitivity, making it affordable and deliverable for point-of-care (POC) diagnosis in resource-limited settings.
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Cites
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444
Extracellular vesicles in cancer — implications for future improvements in cancer care
Xu, R., Rai, A., Chen, M., Suwakulsiri, W., Greening, D. W., & Simpson, R. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0036-9 · Cited by 1,445
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
Im, H., Shao, H., Park, Y. I., Peterson, V. M., Castro, C. M., Weissleder, R., & Lee, H. (2014) · Nature Biotechnology · doi:10.1038/nbt.2886 · Cited by 1,321
Tumor-Derived Exosomes and Their Role in Cancer Progression
(2016) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2015.12.005 · Cited by 755
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
Aptamer/AuNP Biosensor for Colorimetric Profiling of Exosomal Proteins
Jiang, Y., Shi, M., Liu, Y., Wan, S., Cui, C., Zhang, L., & Tan, W. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201703807 · Cited by 487
Wang, S., Zhang, L., Wan, S., Cansiz, S., Cui, C., Liu, Y., Cai, R., Hong, C., Teng, I.-T., Shi, M., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00373 · Cited by 476
Chang, J., Wang, X., Wang, J., Li, H., & Li, F. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05599 · Cited by 469
Self-citationYang, X., Tang, Q., Jiang, Y., Zhang, M., Wang, M., & Mao, L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11996 · Cited by 403
Metadata
- Authors
- Liu, X., Gao, X., Yang, L., Zhao, Y., & Li, F.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2021-08-19
- Volume
- 93
- Issue
- 34
- Pages
- 11792-11799
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W3193569631
- Cited by
- 334
- References
- 50
- FWCI
- 14.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, X., Gao, X., Yang, L., Zhao, Y., & Li, F. (2021). Metal–Organic Framework-Functionalized Paper-Based Electrochemical Biosensor for Ultrasensitive Exosome Assay. Analytical Chemistry. https://doi.org/10.1021/acs.analchem.1c02286
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