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Enabling Technologies for Personalized and Precision Medicine
Open accessAbstract
Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.
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“As a result of these flaws, RCTs do not dynamically or accurately determine the best treatments and tailored regimens, which may change as patient behaviour and neurobiology evolves during the course of treatment.41”
From Precision clinical trials: a framework for getting to precision medicine for neurobehavioural disorders (2021) · cites this paper as [41]
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Metadata
- Authors
- Ho, D., Quake, S. R., McCabe, E. R. B., Chng, W. J., Chow, E. K., Ding, X., Gelb, B. D., Ginsburg, G. S., Hassenstab, J., Ho, C.-M., Mobley, W. C., Nolan, G. P., Rosen, S. T., Tan, P., Yen, Y., & Zarrinpar, A.
- Affiliations
- National University of Singapore (SG)
- Chan Zuckerberg Biohub San Francisco (US)
- March of Dimes (US)
- Shanghai Jiao Tong University (CN)
- Icahn School of Medicine at Mount Sinai (US)
- Duke University (US)
- Washington University in St. Louis (US)
- University of California, Los Angeles (US)
- University of California San Diego (US)
- Stanford University (US)
- City Of Hope National Medical Center (US)
- Taipei Medical University (TW)
- University of Florida Health (US)
- Corresponding author
- Ho, Dean
- McCabe, Edward R.B.
- ORCID
- Venue
- Trends in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 38
- Issue
- 5
- Pages
- 497-518
- ISSN
- 0167-7799 (ISSN-L)
- PMC
- PMC7924935
- OpenAlex
- W3001878481
- Cited by
- 517
- References
- 212
- Citations by year
- 2026: 97 · 2025: 143 · 2024: 106 · 2023: 67 · 2022: 48 · 2021: 39 · 2020: 17
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in biotechnology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- V Foundation for Cancer Research
- National Research Foundation Singapore
- Wallace H. Coulter Foundation
- National Institutes of Health
- Ministry of Education - Singapore
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Technology and Human Factors in Education and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- personalized medicine, precision medicine, biomarker discovery, disease signatures, personalized treatment, drug selection, dose optimization, enabling technologies, individualized care
- MeSH terms
- Artificial Intelligence, Diagnosis, Humans, Therapeutics, Biomarkers, Precision Medicine
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