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Cited by 36

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Rho A and Rac1: Antagonists moving forward

Salloum, Gilbert, Jaafar, Leila, El-Sibai, Mirvat·2020·Tissue and Cell
DOI 10.1016/j.tice.2020.101364
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Abstract

Cells detect external stimuli through cell-surface receptors. In cases where the stimulus is a cytokine or a growth factor, the cell responds by inducing modifications in the actin cytoskeleton. These changes are mediated through the Rho family of GTPases. Among these GTPases, RhoA, Rac1 and Cdc42 have been extensively studied. The activity of these proteins is closely monitored and tightly regulated through Guanine-nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) that turn the "switch" on and off respectively. Crosstalk between Rho GTPases has been long studied; yet many questions are raised regarding the spatiotemporal regulation of these GTPases, particularly RhoA and Rac1. This review sheds a light on the antagonistic relationship between both GTPases and puts emphasis on the importance of cycling of RhoA activation at the focal adhesions for optimal cell migration.

Overview

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Registry

Crossref · 10.1016/j.tice.2020.101364

Cites

74 of 74 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. El-Sibai, 2008, RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells, Exp. Cell Res., 314, 1540, 10.1016/j.yexcr.2008.01.016 · DOI
  2. Lawson, 2017, Rho GTPase signaling complexes in cell migration and invasion, J. Cell Biol.
  3. Mouneimne, 2004, Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation, J. Cell Biol., 166, 697, 10.1083/jcb.200405156 · DOI

Cited by

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Metadata

Authors
Salloum, G., Jaafar, L., & El-Sibai, M.
Venue
Tissue and Cell
Publisher
Elsevier BV
Published
2020-08
Volume
65
Pages
101364
ISSN
0040-8166
DOI
10.1016/j.tice.2020.101364
Cited by
36
References
74
Language
en
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
American University

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.