Cited by 112Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.

Mitochondrial DNA mutations and aging: devils in the details?

Open access

Khrapko, Konstantin, Vijg, Jan·2009·Trends in Genetics

DOI 10.1016/j.tig.2008.11.007PMC PMC2811092

Open this paper in CoChat — free account

Abstract

Although several lines of evidence support a role for accumulating somatic mitochondrial DNA (mtDNA) mutations in the etiology of aging, it remains unclear if they are a major cause of age-related deterioration and death. Mouse models that harbor elevated mtDNA mutation frequencies age prematurely; these findings were thought to provide conclusive evidence for a causal role of such mutations in aging. Yet, the presence of several conflicting reports has sparked controversy in the field and this is further aggravated by discrepancies in the estimates of mtDNA mutant fractions, which disagree by orders of magnitude. Here, we briefly review the evidence and some of the unresolved questions surrounding a causative role for accumulating mtDNA mutations in aging.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tig.2008.11.007

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 2,026
Extension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724
Mitochondrial Respiratory-Chain Diseases
DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,672
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570
Mitochondrial Oxidative Stress: Implications for Cell Death
Orrenius, S., Gogvadze, V. G., & Zhivotovsky, B. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105122 · Cited by 1,294
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,262
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
Linnane, A., Ozawa, T., Marzuki, S., & Tanaka, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92145-4 · Cited by 983
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 896
Self-citation

Show all 68 references

Sorted by citations

The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.011 · Cited by 1,275
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990
Mitochondrial dysfunction in Parkinson's disease
Winklhofer, K. F., & Haass, C. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.013 · Cited by 688
The Mitochondrial Basis of Aging and Age-Related Disorders
Srivastava, S. (2017) · Genes · doi:10.3390/genes8120398 · Cited by 446
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 425
Genome Instability and Aging
Vijg, J., & Suh, Y. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183715 · Cited by 399
Self-citation
Mitochondrial dysfunction in aging: Much progress but many unresolved questions
Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335
Skeletal Muscle Mitochondria and Aging: A Review
Peterson, C. M., Johannsen, D. L., & Ravussin, É. (2012) · Journal of Aging Research · doi:10.1155/2012/194821 · Cited by 337
C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction
Guescini, M., Guidolin, D., Vallorani, L., Casadei, L., Gioacchini, A. M., Tibollo, P., Battistelli, M., Falcieri, E., Battistin, L., Agnati, L. F., et al. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.006 · Cited by 294
A review and appraisal of the DNA damage theory of ageing
Freitas, A. A., & de Magalhães, J. P. (2011) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2011.05.001 · Cited by 256
Oxidative DNA damage and nucleotide excision repair
Melis, J. P. M., van Steeg, H., & Luijten, M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5036 · Cited by 234
Mitochondria and Aging
Lee, H., & Wei, Y. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_14 · Cited by 207
Potential Therapeutic Benefits of Strategies Directed to Mitochondria
Camara, A. K. S., Lesnefsky, E. J., & Stowe, D. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2788 · Cited by 199
Mitochondria and Ageing
Leeuwenburgh, C., Pamplona, R., & Sanz, A. (2011) · Journal of Aging Research · doi:10.4061/2011/782946 · Cited by 186
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations
Itsara, L. S., Kennedy, S. R., Fox, E. J., Yu, S., Hewitt, J. J., Sanchez-Contreras, M., Cardozo-Pelaez, F., & Pallanck, L. J. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1003974 · Cited by 173
Multifaceted Mechanisms of Vascular Calcification in Aging
Pescatore, L. A., Gamarra, L. F., & Liberman, M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311576 · Cited by 167
Genome instability, cancer and aging
Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 134
Self-citation
Mitochondrial Heterogeneity
Aryaman, J., Johnston, I. G., & Jones, N. S. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00718 · Cited by 123
Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6
Zhang, Y., Guo, L., Han, S., Chen, L., Li, C., Zhang, Z., Hong, Y., Zhang, X., Zhou, X., Jiang, D., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03289-w · Cited by 112
Impaired quality control of mitochondria: Aging from a new perspective
Weber, T. A., & Reichert, A. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.018 · Cited by 112
Genetic and epigenetic regulation of aging
Fraga, M. F. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.04.003 · Cited by 114
Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106
Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Luan, Y., Zhu, X., Jiao, Y., Liu, H., Huang, Z., Pei, J., Xu, Y., Yang, Y., & Ren, K. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01792-5 · Cited by 116
Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects
Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Ishikawa, K., Nakada, K., Soda, M., Mano, H., Togayachi, S., Miyoshi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep10434 · Cited by 83
Somatic mtDNA Mutation Spectra in the Aging Human Putamen
Williams, S. L., Mash, D. C., Zuchner, S. L., & Moraes, C. T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003990 · Cited by 84
Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease
Chao, J., Leung, Y., Wang, M., & Chang, R. C. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00484.x · Cited by 79
Mitochondrial DNA Rearrangements in Health and Disease-A Comprehensive Study
Damas, J., Samuels, D. C., Carneiro, J., Amorim, A., & Pereira, F. (2013) · Human Mutation · doi:10.1002/humu.22452 · Cited by 77
Mitochondria: multifaceted regulators of aging
Son, J. M., & Lee, C. D. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.300 · Cited by 76
Fast Mitochondrial DNA Isolation from Mammalian cells for Next-Generation Sequencing
Quispe‐Tintaya, W., White, R. R., Popov, V. N., Vijg, J., & Maslov, A. Y. (2013) · BioTechniques · doi:10.2144/000114077 · Cited by 76
Self-citation
Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms
Scialò, F., Mallikarjun, V., Stefanatos, R. K. A., & Sanz, A. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4900 · Cited by 70
Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development
Hashizume, O., Shimizu, A., Yokota, M., Sugiyama, A., Nakada, K., Miyoshi, H., Itami, M., Ohira, M., Nagase, H., Takenaga, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202367109 · Cited by 69
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity
Gregg, T., Poudel, C., Schmidt, B., Dhillon, R. S., Sdao, S. M., Truchan, N. A., Baar, E. L., Fernandez, L. A., Denu, J. M., Eliceiri, K. W., et al. (2016) · Diabetes · doi:10.2337/db16-0432 · Cited by 70
Targeted enrichment and high‐resolution digital profiling of mitochondrial DNA deletions in human brain
Taylor, S. D., Ericson, N. G., Burton, J. N., Prolla, T. A., Silber, J. R., Shendure, J., & Bielas, J. H. (2014) · Aging Cell · doi:10.1111/acel.12146 · Cited by 67
Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson’s Disease
Chen, T., Tan, J., Wan, Z., Zou, Y., Afewerky, H. K., Zhang, Z., & Zhang, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122507 · Cited by 67
Genetics vs. entropy: Longevity factors suppress the NF-κB-driven entropic aging process
Salminen, A., & Kaarniranta, K. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.11.001 · Cited by 67
Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?
Giuliani, A., Prattichizzo, F., Micolucci, L., Ceriello, A., Procopio, A. D., & Rippo, M. R. (2017) · Mediators of Inflammation · doi:10.1155/2017/2309034 · Cited by 66
Mitochondrial Network State Scales mtDNA Genetic Dynamics
Aryaman, J., Bowles, C., Jones, N. S., & Johnston, I. G. (2019) · Genetics · doi:10.1534/genetics.119.302423 · Cited by 57
Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain
Andriani, G. A., Vijg, J., & Montagna, C. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.007 · Cited by 56
Self-citation
Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal
Tani, H., Ohnishi, S., Shitara, H., Mito, T., Yamaguchi, M., Yonekawa, H., Hashizume, O., Ishikawa, K., Nakada, K., & Hayashi, J. (2018) · Scientific Reports · doi:10.1038/s41598-017-18828-3 · Cited by 54
Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus
Khan, S., Raghuram, G. V., Bhargava, A., Pathak, N., Chandra, D. H., Jain, S. K., & Mishra, P. K. (2011) · Translational research · doi:10.1016/j.trsl.2011.08.007 · Cited by 49
Mitochondrial DNA Mutations in Aging
Khrapko, K., & Turnbull, D. M. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00002-7 · Cited by 47
Self-citation
Mitonuclear genomics and aging
Reynolds, J. C., Bwiza, C. P., & Lee, C. D. (2020) · Human Genetics · doi:10.1007/s00439-020-02119-5 · Cited by 56
PoolHap: Inferring Haplotype Frequencies from Pooled Samples by Next Generation Sequencing
Long, Q., Jeffares, D. C., Zhang, Q., Ye, K., Nizhynska, V., Ning, Z., Tyler‐Smith, C., & Nordborg, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015292 · Cited by 45
Do mtDNA deletions drive premature aging in mtDNA mutator mice?
Kraytsberg, Y., Simon, D. K., Turnbull, D. M., & Khrapko, K. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00484.x · Cited by 42
Self-citation
Mitochondrial Inverted Repeats Strongly Correlate with Lifespan: mtDNA Inversions and Aging
Yang, J.-N., Seluanov, A., & Gorbunova, V. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073318 · Cited by 40
Mitochondrial DNA, chloroplast DNA and the origins of development in eukaryotic organisms
Bendich, A. J. (2010) · Biology Direct · doi:10.1186/1745-6150-5-42 · Cited by 39
Reinforcing mitochondrial functions in aging brain: An insight into Parkinson's disease therapeutics
Chandra, G., Shenoi, R. A., Anand, R., Rajamma, U., & Mohanakumar, K. P. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.12.004 · Cited by 39
On the timing and the extent of clonal expansion of mtDNA deletions: Evidence from single-molecule PCR
Nicholas, A., Kraytsberg, Y., Guo, X., & Khrapko, K. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.029 · Cited by 38
Self-citation
Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development
Mito, T., Kikkawa, Y., Shimizu, A., Hashizume, O., Katada, S., Imanishi, H., Ota, A., Kato, Y., Nakada, K., & Hayashi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055789 · Cited by 38
Cellular mechanical memory: a potential tool for mesenchymal stem cell-based therapy
Kureel, S. K., Maroto, R., Davis, K., & Sheetz, M. P. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04249-x · Cited by 41
Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Spyrou, J., Gardner, D. K., & Harvey, A. J. (2019) · Stem Cells International · doi:10.1155/2019/7360121 · Cited by 33
Mitochondrial DNA Damage and Animal Longevity: Insights from Comparative Studies
Pamplona, R. (2011) · Journal of Aging Research · doi:10.4061/2011/807108 · Cited by 32
Cellular Aging Characteristics and Their Association with Age-Related Disorders
Rudzińska, M., Parodi, A., Balakireva, A. V., Chepikova, O. E., Venanzi, F. M., & Zamyatnin, A. A. (2020) · Antioxidants · doi:10.3390/antiox9020094 · Cited by 32
Somatic mutations in aging and disease
Ren, P., Zhang, J., & Vijg, J. (2024) · GeroScience · doi:10.1007/s11357-024-01113-3 · Cited by 30
Self-citation
Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing
Giuliani, C., Barbieri, C., Li, M., Bucci, L., Monti, D., Passarino, G., Luiselli, D., Franceschi, C., Stoneking, M., & Garagnani, P. (2014) · Aging · doi:10.18632/aging.100661 · Cited by 29
The molecular basis of longevity, and clinical implications
Marques, F. Z., Markus, M. A., & Morris, B. J. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.12.008 · Cited by 31
Somatic Cells with a Heavy Mitochondrial DNA Mutational Load Render Induced Pluripotent Stem Cells with Distinct Differentiation Defects
Wahlestedt, M., Ameur, A., Moraghebi, R., Norddahl, G. L., Sten, G., Woods, N., & Bryder, D. (2014) · Stem Cells · doi:10.1002/stem.1630 · Cited by 29
Control of DNA integrity in skeletal muscle under physiological and pathological conditions
Saada, Y. B., Zakharova, V., Chernyak, B. V., Dib, C., Carnac, G., Dokudovskaya, S., & Vassetzky, Y. S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2530-0 · Cited by 25
Cellular and population level processes influence the rate, accumulation and observed frequency of inherited and somatic mtDNA mutations
Melvin, R. G., & Ballard, J. W. O. (2017) · Mutagenesis · doi:10.1093/mutage/gex004 · Cited by 24
Mitochondrial DNA deletions in mice in men: Substantia nigra is much less affected in the mouse
Guo, X., Kudryavtseva, E., Bodyak, N. D., Nicholas, A., Dombrovsky, I., Yang, D., Kraytsberg, Y., Simon, D. K., & Khrapko, K. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.005 · Cited by 23
Self-citation
Why Is Modern Medicine Stuck in a Rut?
Mittra, I. (2009) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0131 · Cited by 22
Mitochondrial DNA Rearrangement Spectrum in Brain Tissue of Alzheimer’s Disease: Analysis of 13 Cases
Chen, Y., Liu, C., Parker, W. D., Chen, H., Beach, T. G., Liu, X., Serrano, G. E., Lu, Y., Huang, J., Yang, K., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154582 · Cited by 21
Roles of Mitochondrial DNA Mutations in Stem Cell Ageing
Su, T., Turnbull, D. M., & Greaves, L. C. (2018) · Genes · doi:10.3390/genes9040182 · Cited by 23
Oxyphil Cell Metaplasia in the Parathyroids Is Characterized by Somatic Mitochondrial DNA Mutations in NADH Dehydrogenase Genes and Cytochrome c Oxidase Activity–Impairing Genes
Müller‐Höcker, J., Schäfer, S., Krebs, S., Blum, H., Zsurka, G., Kunz, W. S., Prokisch, H., Seibel, P., & Jung, A. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.07.015 · Cited by 20
YAF2-Mediated YY1-Sirtuin6 Interactions Responsible for Mitochondrial Downregulation in Aging Tunicates
Kawamura, K., Higuchi, T., & Fujiwara, S. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00047-21 · Cited by 17
New approaches for modelling sporadic genetic disease in the mouse
Fisher, E., Lana‐Elola, E., Watson, S. D., Vassiliou, G. S., & Tybulewicz, V. L. J. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001644 · Cited by 19
Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging
Hayashi, J., Hashizume, O., Ishikawa, K., & Shimizu, A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.03.004 · Cited by 17
Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue Regeneration
Henriques‐Pons, A., Beghini, D. G., Silva, V. S., Horita, S. I. M., & da Silva, F. A. B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.780900 · Cited by 17
Correction: Somatic mtDNA Mutation Spectra in the Aging Human Putamen
Williams, S. L., Mash, D. C., Zuchner, S. L., & Moraes, C. T. (2013) · PLoS Genetics · doi:10.1371/annotation/4b800314-8d35-454d-afca-af6d0f57b5d1 · Cited by 16
Links between telomere dysfunction and hallmarks of aging
Li, S., Liu, Z., Zhang, J., & Li, L. (2023) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2023.503617 · Cited by 15
Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders
Tani, H., Mito, T., Velagapudi, V., Ishikawa, K., Umehara, M., Nakada, K., Suomalainen, A., & Hayashi, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-52372-6 · Cited by 14
Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders
Mito, T., Ishizaki, H., Suzuki, M., Morishima, H., Ota, A., Ishikawa, K., Nakada, K., Maeno, A., Shiroishi, T., & Hayashi, J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.009 · Cited by 13
Muscle Development and Regeneration in Normal and Pathological Conditions: Learning from Drosophila
Daczewska, M., Picchio, L., Jagla, T., Figeac, N., & Jagla, K. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883462 · Cited by 12
Rapid Mitochondrial DNA Isolation Method for Direct Sequencing
Quispe‐Tintaya, W., White, R. R., Popov, V. N., Vijg, J., & Maslov, A. Y. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2257-4_9 · Cited by 12
Self-citation
Concise Review: The Epigenetic Contribution to Stem Cell Ageing: Can We Rejuvenate Our Older Cells?
Armstrong, L., Al-Aama, J. Y., Stojković, M., & Lako, M. (2014) · Stem Cells · doi:10.1002/stem.1720 · Cited by 11
Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype
Takibuchi, G., Imanishi, H., Morimoto, M., Ishikawa, K., Nakada, K., Toyama‐Sorimachi, N., Kikkawa, Y., Takenaga, K., & Hayashi, J. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.07.117 · Cited by 10
Mito-mice∆ and mitochondrial DNA mutator mice as models of human osteoporosis caused not by aging but by hyperparathyroidism
Mito, T., Tani, H., Suzuki, M., Ishikawa, K., Nakada, K., & Hayashi, J. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0060 · Cited by 9
Long-term models of oxidative stress and mitochondrial damage in insulin resistance progression
Graham, E. J., & Adler, F. R. (2013) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2013.09.028 · Cited by 9
High frequency of somatic mutations in rat liver mitochondrial DNA
Rotskaya, U. N., Rogozin, I. B., Vasyunina, E. A., Malyarchuk, B. А., Nevinsky, G. A., & Sinitsyna, O. I. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.12.010 · Cited by 9
Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays
Antipova, V. N., Malakhova, L. V., & Bezlepkin, V. G. (2011) · BIOPHYSICS · doi:10.1134/s0006350911030031 · Cited by 8
Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System
Imanishi, H., Takibuchi, G., Kobayashi, T., Ishikawa, K., Nakada, K., Mori, M., Kikkawa, Y., Takenaga, K., Toyama‐Sorimachi, N., & Hayashi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075981 · Cited by 6
Mitochondrial DNA deletions in tissues of mice after ionizing radiation exposure
Antipova, V. N., Lomaeva, M. G., & Zyrina, N. V. (2017) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1419299 · Cited by 5
Brown adipose tissue: a potential target for aging interventions and healthy longevity
Li, H., Li, J., Song, C., Yang, H., Luo, Q., & Chen, M. (2024) · Biogerontology · doi:10.1007/s10522-024-10137-3 · Cited by 6
Potential of nanoparticles and nanopolymers in treatment of age-associated diseases
Saadatpour, F., Mohammadipanah, F., Zohourian, N., & Hodjat, M. (2021) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6262/ac42c7 · Cited by 3
Advantages and considerations in the confirmation of mitochondrial DNA mutations by denaturing HPLC and pyrosequencing
Yen, H., Hsu, W., Lin, C., Chen, G., & Huang, Y. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05626.x · Cited by 3
Mitochondrial theory of skeletal muscle ageing –new facts, new doubts
Słodki, S., & Bogucka, J. (2019) · Journal of Veterinary Research · doi:10.2478/jvetres-2019-0015 · Cited by 4
Mitochondria
Zick, M., & Reichert, A. S. (2011) · Wiley eBooks · doi:10.1002/9781118015759.ch6 · Cited by 3
Mitochondrial DNA Mutations and Cancer
Popadin, K. Y., Владимирович, Г. К., & Khrapko, K. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.001 · Cited by 2
Self-citation
10.1538/expanim.63.459
xxxxxxxxxx, X. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.63.459 · Cited by 2
Administration of an Antioxidant Prevents Lymphoma Development in Transmitochondrial Mice Overproducing Reactive Oxygen Species
Yamanashi, H., Hashizume, O., Yonekawa, H., Nakada, K., & Hayashi, J. (2014) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.14-0038 · Cited by 2
Investigation of the genetical basis of autosomal recessive Cutis Laxa
Dimopoulou, A. (2010) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8006 · Cited by 2
miR-542: a novel regulator for muscle mass and function
Garros, R. F. (2017) · Spiral (Imperial College London) · doi:10.25560/68036 · Cited by 2
A metabolic and mitochondrial angle on aging
Duarte, A. I., Sadowska‐Bartosz, I., Karkucińska‐Więckowska, A., Lebiedzińska, M., Palmeira, C. M., Rolo, A. P., Kabiri, Y., Zavan, B., Pinton, P., Borges, F., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00024-0 · Cited by 3
Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration
Vega-García, A., Apolinar, L. M., Feria-Romero, I. A., Campos‐Bedolla, P., Alberto, G.-G. C., Luna‐Munguía, H., Sofía, R.-H., & Orozco-Suárez, S. A. (2026) · Brain Sciences · doi:10.3390/brainsci16101019 · Cited by 1
Epigenetics of Brain Aging
Cacabelos, R., & Teijido, Ó. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00074-9 · Cited by 1
A somatic T15091C mutation in the Cytb gene of mouse mitochondrial DNA dominantly induces respiration defects
Hayashi, C., Takibuchi, G., Shimizu, A., Mito, T., Ishikawa, K., Nakada, K., & Hayashi, J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.052 · Cited by 1
Friend or Foe
Annis, S., Safdar, A., Biala, E., Saleem, A., Li, H., Gandhi, P., Fleischmann, Z., Castaneda‐Sceppa, C., Tilly, J. L., Woods, D. C., et al. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch31 · Cited by 1
Self-citation
The Role of Mitochondria in Age‐Related Sarcopenia
Ferrucci, L., Zampino, M., Coen, P. M., & Goodpaster, B. H. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch3 · Cited by 2
Are mitochondrial DNA mutations under purifying selection in somatic tissues?Preprint
Franco, M., Bandell, J., Popadin, K. Y., Woods, D., & Khrapko, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.26.684677 · Cited by 1
Self-citation

Authors: Khrapko, K., & Vijg, J.
Affiliations: Beth Israel Deaconess Medical Center (US)
Albert Einstein College of Medicine (US)
Corresponding author: Khrapko, Konstantin
Vijg, Jan
ORCID: Khrapko, Konstantin
Vijg, Jan
Venue: Trends in Genetics
Publisher: Elsevier BV
Published: 2009-02
Volume: 25
Issue: 2
Pages: 91-98
ISSN: 0168-9525 (ISSN-L)
DOI: 10.1016/j.tig.2008.11.007
PMC: PMC2811092
OpenAlex: W1996511649
Cited by: 112
References: 68
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 13 · 2012: 5
FWCI: 0.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Genetics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Ellison Medical Foundation
United Mitochondrial Disease Foundation
National Institutes of Health
National Institute on Aging (AG 17242, R01AG020438, AG 20438, P01AG017242, AG19787, R01AG019787)
National Institute of Neurological Disorders and Stroke (NS058988, R01NS058988)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: mitochondrial DNA mutations, aging, premature aging, mouse model
MeSH terms: Aging, Animals, DNA, Mitochondrial, Humans, Mutation, Oxidation-Reduction, Phenotype, Phosphorylation, Stem Cells, Substantia Nigra, Cellular Senescence, Muscle, Skeletal, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondrial DNA mutations and aging: devils in the details?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks