The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
The different levels of genetic diversity in sex chromosomes and autosomes
Abstract
Sex chromosomes and autosomes differ in their effective population size, mutation and demography, all of which affect the relative level of genetic diversity within the genome. Moreover, natural selection acts differentially on the two chromosomal categories, for example, because recessive mutations are directly exposed to selection on the single X chromosome of males. Recent genome analyses reveal a heterogeneous picture of the sex-chromosome-to-autosome diversity ratio in different organisms. Reduced X chromosome diversity has been interpreted to reflect demographic features such as bottlenecks and male-biased dispersal, whereas more equal diversity in sex chromosomes and autosomes has been explained by polygynous mating systems.
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Metadata
- Authors
- Ellegren, H.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Ellegren, Hans
- ORCID
- Ellegren, Hans
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 25
- Issue
- 6
- Pages
- 278-284
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1969937490
- Semantic Scholar
- fc61691f89e6af7396c74178f7bdcbe2f10328e7
- Cited by
- 154
- References
- 60
- Citations by year
- 2026: 13 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 25 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 17 · 2013: 11 · 2012: 14
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- sex chromosomes, autosomes, genetic diversity, effective population size, mutation rate, natural selection, X chromosome, recessive mutations, population bottleneck, male-biased dispersal, polygyny, mating systems
- MeSH terms
- Female, Humans, Male, Selection, Genetic, Sex Chromosomes, Genetic Variation
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- The paper
- Ellegren, H. (2009). The different levels of genetic diversity in sex chromosomes and autosomes. Trends in Genetics. https://doi.org/10.1016/j.tig.2009.04.005
