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Cited by 1,403Genomics and Phylogenetic StudiesChromosomal and Genetic VariationsPrimate Behavior and Ecology

Evolutionary and biomedical insights from the rhesus macaque genome.

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Gibbs, Richard A., Rogers, Jeffrey, Katze, Michael G., Bumgarner, Roger, Weinstock, George M., Mardis, Elaine R., Remington, Karin A., Strausberg, Robert L. +168 more·2007·Science
DOI 10.1126/science.1139247
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Abstract

The rhesus macaque ( Macaca mulatta ) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

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Crossref · 10.1126/science.1139247

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  • The amino acid sequence of the extracellular domains of rhesus and cynomolgus CD28 are identical with the one of human CD28.

    “The amino acid sequence of the extracellular domains of rhesus and cynomolgus CD28 are identical with the one of human CD28 (Fig. S3 and see genebank entries 111144662 and 112817616 for Macaca mulatta and 110611295, 111144664, and 110611297 for Macaca fascicularis as well as ref. [42]).”

    From Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies (2008) · cites this paper as [42]

    The Overview of Genome Features compares human and rhesus nucleotide sequences overall, but does not establish identity of their CD28 extracellular-domain amino acid sequences. Searches for CD28 and the cited GenBank accession numbers found no passage addressing CD28 or the claimed comparison with cynomolgus macaques. (LLM, conf=0.74)

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Authors
Gibbs, R. A., Rogers, J., Katze, M. G., Bumgarner, R., Weinstock, G. M., Mardis, E. R., Remington, K. A., Strausberg, R. L., Venter, J. C., Wilson, R. K., Batzer, M. A., Bustamante, C. D., Eichler, E. E., Hahn, M. W., Hardison, R. C., Makova, K. D., Miller, W., Milosavljevic, A., Palermo, R. E., Siepel, A., Sikela, J. M., Attaway, T., Bell, S., Bernard, K. E., Buhay, C. J., Chandrabose, M. N., Dao, M., Davis, C., Delehaunty, K. D., Ding, Y., Dinh, H. H., Dugan-Rocha, S., Fulton, L. A., Gabisi, R. A., Garner, T. T., Godfrey, J., Hawes, A. C., Hernandez, J., Hines, S., Holder, M., Hume, J., Jhangiani, S. N., Joshi, V., Khan, Z. M., Kirkness, E. F., Cree, A., Fowler, R. G., Lee, S., Lewis, L. R., Li, Z., Liu, Y.-S., Moore, S. M., Muzny, D., Nazareth, L. V., Ngo, D. N., Okwuonu, G. O., Pai, G., Parker, D., Paul, H. A., Pfannkoch, C., Pohl, C. S., Rogers, Y.-H., Ruiz, S. J., Sabo, A., Santibanez, J., Schneider, B. W., Smith, S. M., Sodergren, E., Svatek, A. F., Utterback, T. R., Vattathil, S., Warren, W., White, C. S., Chinwalla, A. T., Feng, Y., Halpern, A. L., Hillier, L. W., Huang, X., Minx, P., Nelson, J. O., Pepin, K. H., Qin, X., Sutton, G. G., Venter, E., Walenz, B. P., Wallis, J. W., Worley, K. C., Yang, S.-P., Jones, S. M., Marra, M. A., Rocchi, M., Schein, J. E., Baertsch, R., Clarke, L., Csürös, M., Glasscock, J., Harris, R. A., Havlak, P., Jackson, A. R., Jiang, H., Liu, Y., Messina, D. N., Shen, Y., Song, H. X.-Z., Wylie, T., Zhang, L., Birney, E., Han, K., Konkel, M. K., Lee, J., Smit, A. F. A., Ullmer, B., Wang, H., Xing, J., Burhans, R., Cheng, Z., Karro, J. E., Ma, J., Raney, B., She, X., Cox, M. J., Demuth, J. P., Dumas, L. J., Han, S.-G., Hopkins, J., Karimpour-Fard, A., Kim, Y. H., Pollack, J. R., Vinar, T., Addo-Quaye, C., Degenhardt, J., Denby, A., Hubisz, M. J., Indap, A., Kosiol, C., Lahn, B. T., Lawson, H. A., Marklein, A., Nielsen, R., Vallender, E. J., Clark, A. G., Ferguson, B., Hernandez, R. D., Hirani, K., Kehrer-Sawatzki, H., Kolb, J., Patil, S., Pu, L.-L., Ren, Y., Smith, D. G., Wheeler, D. A., Schenck, I., Ball, E. V., Chen, R., Cooper, D. N., Giardine, B., Hsu, F., Kent, W. J., Lesk, A., Nelson, D. L., O'Brien, W. E., Prüfer, K., Stenson, P. D., Wallace, J. C., Ke, H., Liu, X.-M., Wang, P., Xiang, A. P., Yang, F., Barber, G. P., Haussler, D., Karolchik, D., Kern, A. D., Kuhn, R. M., Smith, K. E., & Zwieg, A. S.
Affiliations
  • Texas Biomedical Research Institute (US)
  • Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2007-04-13
Volume
316
Issue
5822
Pages
222-234
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1139247
OpenAlex
W2125548284
Cited by
1,403
References
69
Citations by year
2026: 28 · 2025: 51 · 2024: 34 · 2023: 63 · 2022: 69 · 2021: 69 · 2020: 53 · 2019: 50 · 2018: 59 · 2017: 46 · 2016: 51 · 2015: 73 · 2014: 74 · 2013: 78 · 2012: 98
FWCI
52.32
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
  • Civil War Book Review (submittedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Funders
  • Wellcome Trust (062023)
  • National Human Genome Research Institute (U54HG003068, U54HG003079, R01HG002939)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Keywords
rhesus monkeys, genome sequence, comparative genomics, primate evolution, positive selection, gene family expansion and contraction, genetic diversity, nonhuman primate model
MeSH terms
Animals, Pan troglodytes, Female, Multigene Family, Humans, Macaca mulatta, Male, Mutation, Species Specificity, Genetic Variation, Gene Rearrangement, Genome, Sequence Analysis, DNA, Evolution, Molecular, Gene Duplication, Genetic Diseases, Inborn, Biomedical Research

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