Cited by 166Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesEvolution and Genetic DynamicsGenetic diversity and population structure

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The different levels of genetic diversity in sex chromosomes and autosomes

Ellegren, Hans·2009·Trends in Genetics

DOI 10.1016/j.tig.2009.04.005

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Abstract

Sex chromosomes and autosomes differ in their effective population size, mutation and demography, all of which affect the relative level of genetic diversity within the genome. Moreover, natural selection acts differentially on the two chromosomal categories, for example, because recessive mutations are directly exposed to selection on the single X chromosome of males. Recent genome analyses reveal a heterogeneous picture of the sex-chromosome-to-autosome diversity ratio in different organisms. Reduced X chromosome diversity has been interpreted to reflect demographic features such as bottlenecks and male-biased dispersal, whereas more equal diversity in sex chromosomes and autosomes has been explained by polygynous mating systems.

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Authors: Ellegren, H.
Affiliations: Uppsala University (SE)
Corresponding author: Ellegren, Hans
ORCID: Ellegren, Hans
Venue: Trends in Genetics
Publisher: Elsevier BV
Published: 2009-06
Volume: 25
Issue: 6
Pages: 278-284
ISSN: 0168-9525 (ISSN-L)
DOI: 10.1016/j.tig.2009.04.005
OpenAlex: W1969937490
Semantic Scholar: fc61691f89e6af7396c74178f7bdcbe2f10328e7
Cited by: 154
References: 60
Citations by year: 2026: 13 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 25 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 17 · 2013: 11 · 2012: 14
FWCI: 0.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Vetenskapsrådet
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords: sex chromosomes, autosomes, genetic diversity, effective population size, mutation rate, natural selection, X chromosome, recessive mutations, population bottleneck, male-biased dispersal, polygyny, mating systems
MeSH terms: Female, Humans, Male, Selection, Genetic, Sex Chromosomes, Genetic Variation

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The different levels of genetic diversity in sex chromosomes and autosomes

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