The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Evolution of the mutation rate
Open accessAbstract
Understanding the mechanisms of evolution requires information on the rate of appearance of new mutations and their effects at the molecular and phenotypic levels. Although procuring such data has been technically challenging, high-throughput genome sequencing is rapidly expanding knowledge in this area. With information on spontaneous mutations now available in a variety of organisms, general patterns have emerged for the scaling of the mutation rate with genome size and for the likely mechanisms driving this pattern. Support is presented for the hypothesis that natural selection pushes mutation rates down to a lower limit set by the power of random genetic drift rather than by intrinsic physiological limitations, and that this has resulted in reduced levels of replication, transcription, and translation fidelity in eukaryotes relative to prokaryotes.
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Cites
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Rate, molecular spectrum, and consequences of human mutation
Lynch, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912629107 · Cited by 792
Self-citationA genome-wide view of the spectrum of spontaneous mutations in yeast.
Lynch, M., Sung, W., Morris, K., Coffey, N., Landry, C. R., Dopman, E. B., Dickinson, W. J., Okamoto, K., Kulkarni, S., Hartl, D. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803466105 · Cited by 708
The evolutionary consequences of erroneous protein synthesis
Allan Drummond, D., & Wilke, C. O. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2662 · Cited by 515
The frequency of errors in protein biosynthesis
Loftfield, R. B., & Vanderjagt, D. (1972) · Biochemical Journal · doi:10.1042/bj1281353 · Cited by 399
Optimization of DNA polymerase mutation rates during bacterial evolution
Loh, E., Salk, J. J., & Loeb, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912451107 · Cited by 81
Cited by
The origin and evolution of mutations in acute myeloid leukemia
Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575
Tissue-specific mutation accumulation in human adult stem cells during life
Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature · doi:10.1038/nature19768 · Cited by 935
Genetic drift, selection and the evolution of the mutation rate
Lynch, M., Ackerman, M. S., Gout, J.-F., Long, H., Sung, W., Thomas, W. K., & Foster, P. L. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.104 · Cited by 911
Self-citationDeterminants of genetic diversity
Ellegren, H., & Galtier, N. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.58 · Cited by 874
Lee, H., Popodi, E., Tang, H., & Foster, P. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210309109 · Cited by 681
Metadata
- Authors
- Lynch, M.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 26
- Issue
- 8
- Pages
- 345-352
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2055595349
- Cited by
- 1,151
- References
- 6
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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