The evolutionary consequences of erroneous protein synthesis
Open accessAbstract
Errors in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape gene and genome evolution. Experimental and theoretical results on this topic have accumulated rapidly in disparate fields, such as neurobiology, protein biosynthesis and degradation and molecular evolution, but with limited communication among disciplines. Here, we review studies of error frequencies, the cellular and organismal consequences of errors and the attendant long-range evolutionary responses to errors. We emphasize major areas in which little is known, such as the failure rates of protein folding, in addition to areas in which technological innovations may enable imminent gains, such as the elucidation of translational missense error frequencies. Evolutionary responses to errors fall into two broad categories: adaptations that minimize errors and their attendant costs and adaptations that exploit errors for the organism's benefit.
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Error-prone transcription implies high phenotypic variability.
“Error-prone transcription implies high phenotypic variability (53–55).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [54]
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Sahakyan, H., Babajanyan, S. G., Wolf, Y. I., & Koonin, E. V. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509015122 · Cited by 15 · see citing works
- Authors
- Allan Drummond, D., & Wilke, C. O.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Wilke, Claus O.
- ORCID
- Wilke, Claus O.
- Venue
- Nature Reviews Genetics
- Published
- 2009-10
- Volume
- 10
- Issue
- 10
- Pages
- 715-724
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC2764353
- OpenAlex
- W2034108516
- Cited by
- 515
- References
- 102
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 28 · 2023: 26 · 2022: 40 · 2021: 39 · 2020: 33 · 2019: 28 · 2018: 32 · 2017: 28 · 2016: 28 · 2015: 28 · 2014: 37 · 2013: 33 · 2012: 28
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (P50GM068763, R01GM088344)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- protein synthesis errors, translational errors, error rate, protein degradation, molecular evolution, genome evolution, cell fitness, disease phenotypes, error tolerance
- MeSH terms
- Animals, Genetic Code, Humans, Transcription, Genetic, Protein Biosynthesis, Protein Folding, Evolution, Molecular
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