Cited by 399RNA and protein synthesis mechanismsEvolution and Genetic DynamicsProtein Structure and Dynamics

The frequency of errors in protein biosynthesis

Open access
Loftfield, R B, Vanderjagt, D·1972·Biochemical Journal

Abstract

Every protein molecule consists basically of a

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1042/bj1281353

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Error frequencies of 0.01-0.1% per amino acid have been estimated for misincorporating structurally similar amino acids in vivo.

    “Error frequencies of 0.01-0.1% per amino acid (AA) have been estimated for misincorporating structurally similar amino acids in vivo 20 .”

    From How many human proteoforms are there? (2018) · cites this paper as [20]

    The rabbit haemoglobin peptide discussion (page not specified in our copy) estimates 2–6 substitutions per 10,000 sites, or 0.02–0.06%, within the claimed range. But the authors say it remains uncertain whether the measured valine incorporation is largely substitution for isoleucine or whether other structurally similar amino-acid pairs have comparable error frequencies. The experiment used incubated rabbit reticulocytes, rather than measuring errors in vivo. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 3 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Loftfield, R. B., & Vanderjagt, D.
Affiliations
University of New Mexico (US)
Venue
Biochemical Journal
Published
1972-08-01
Volume
128
Issue
5
Pages
1353-1356
ISSN
0306-3283 (ISSN-L)
OpenAlex
W1923250545
Cited by
399
References
3
Citations by year
2026: 7 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 15 · 2013: 8 · 2012: 7
FWCI
2.35
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
protein synthesis, error rate, translation errors, protein synthesis fidelity, aminoacyl-tRNA
MeSH terms
Amino Acid Sequence, Animals, DNA, Genetic Code, Hemoglobins, Hemoglobins, Abnormal, Humans, Rabbits, Reticulocytes, RNA, Transcription, Genetic, Protein Biosynthesis, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review