Autism and Cancer Share Risk Genes, Pathways, and Drug Targets
Open accessAbstract
Autism is a neurodevelopmental disorder, diagnosed behaviorally by social and communication deficits, repetitive behaviors, and restricted interests. Recent genome-wide exome sequencing has revealed extensive overlap in risk genes for autism and for cancer. Understanding the genetic commonalities of autism(s) and cancer(s), with a focus on mechanistic pathways, could lead to repurposed therapeutics.
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Module 2 is rather homogeneous in terms of protein function, whereas M1 comprises diverse functional categories, including genes involved in the ubiquitin pathway and in cancer.
“Whereas module 2 is rather homogeneous in terms of protein function, M1 comprises diverse functional categories, including genes involved in the ubiquitin pathway and in cancer (see below), in line with previous observations57, 58.”
From Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders (2017) · cites this paper as [58]
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Cites
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- Authors
- Crawley, J. N., Heyer, W.-D., & LaSalle, J. M.
- Affiliations
- University of California Davis Medical Center (US)
- UC Davis Comprehensive Cancer Center (US)
- Corresponding author
- Crawley, Jacqueline N.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 32
- Issue
- 3
- Pages
- 139-146
- ISSN
- 0168-9525 (ISSN-L)
- PMC
- PMC4769654
- OpenAlex
- W2271547455
- Cited by
- 134
- References
- 13
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 13 · 2023: 17 · 2022: 12 · 2021: 18 · 2020: 15 · 2019: 12 · 2018: 14 · 2017: 12 · 2016: 3
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Trends in Genetics (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Autism Speaks Targeted Award (8703)
- NINDS (1R01NS085709-01, R01NS081913, R01NS076263)
- NICHD (U54 HD079125)
- NCI (CA92276, CA154920)
- NIHGMS (GM58015)
- DOD (W81XWH-14-1-0435)
- NIEHS (R01ES021707, 2P01ES011269)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- autism spectrum disorder, cancer, gene pathways, therapeutic target, drug repurposing, neurodevelopmental disorders, cancer genomics
- MeSH terms
- Autistic Disorder, Humans, Neoplasms, Genetic Predisposition to Disease
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