The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells
Open accessAbstract
While the vast majority of cellular DNA in eukaryotes is contained in long linear strands in chromosomes, we have long recognized some exceptions like mitochondrial DNA, plasmids in yeasts and double-minutes in cancer cells where the DNA is present in extrachromosomal circles. In addition, specialized extrachromosomal circles of DNA (eccDNA) have been noted to arise from repetitive genomic sequences like telomeric DNA or ribosomal DNA. Recently eccDNA arising from unique (non-repetitive) DNA have been discovered in normal and malignant cells, raising interesting questions about their biogenesis, function and clinical utility. Here we will review recent results and future directions of inquiry on these new forms of eccDNA.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
cGAS surveillance of micronuclei links genome instability to innate immunity
Mackenzie, K. J., Carroll, P., Martin, C.-A., Murina, O., Fluteau, A., Simpson, D. J., Olova, N., Sutcliffe, H., Rainger, J. K., Leitch, A., et al. (2017) · Nature · doi:10.1038/nature23449 · Cited by 1,752
The mitochondrial genome: structure, transcription, translation and replication
Taanman, J.-W. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00161-3 · Cited by 1,635
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Radloff, R., Bauer, W., & Vinograd, J. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.5.1514 · Cited by 1,319
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
Turner, K. M., Deshpande, V., Beyter, D., Koga, T., Rusert, J., Lee, C., Li, B., Arden, K., Ren, B., Nathanson, D. A., et al. (2017) · Nature · doi:10.1038/nature21356 · Cited by 847
Circulating Tumor DNA as a Liquid Biopsy for Cancer
Heitzer, E., Ulz, P., & Geigl, J. B. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.222679 · Cited by 767
Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA
Nathanson, D. A., Gini, B., Mottahedeh, J., Visnyei, K., Koga, T., Gomez, G., Eskin, A., Hwang, K., Wang, J., Masui, K., et al. (2014) · Science · doi:10.1126/science.1241328 · Cited by 695
Gajdusek, D. C., Gibbs, C., Rodgers-Johnson, P., Amyx, H., Asher, D., Epstein, L., Sarin, P., Gallo, R., Maluish, A., Arthur, L., et al. (1985) · The Lancet · doi:10.1016/s0140-6736(85)91011-6 · Cited by 599
THE STRUCTURE AND REPLICATION OF KINETOPLAST DNA
Shapiro, T. A., & Englund, P. T. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.001001 · Cited by 366
MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD
Cox, D., Yuncken, C., & SPRIGGS, A. I. (1965) · The Lancet · doi:10.1016/s0140-6736(65)90131-5 · Cited by 342
Cited by
Small RNA-based antimicrobial immunity
Guo, Z., Li, Y., & Ding, S.-W. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0071-x · Cited by 391
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
Todd, R. T., & Selmecki, A. (2020) · eLife · doi:10.7554/elife.58349 · Cited by 138
Yang, Y., Yang, Y., Huang, H., Song, T., Mao, S., Liu, D., Zhang, L., & Li, W. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-05755-7 · Cited by 41
Chitwood, D. G., Wang, Q., Klaubert, S. R., Green, K., Wu, C. H., Harcum, S. W., & Saski, C. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-27962-0 · Cited by 12
Metadata
- Authors
- Paulsen, T., Kumar, P., Koseoglu, M. M., & Dutta, A.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 34
- Issue
- 4
- Pages
- 270-278
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2783521900
- Cited by
- 264
- References
- 39
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells. https://app.cochat.ai/papers/10.1016/j.tig.2017.12.010
- The paper
- Paulsen, T., Kumar, P., Koseoglu, M. M., & Dutta, A. (2018). Discoveries of Extrachromosomal Circles of DNA in Normal and Tumor Cells. Trends in Genetics. https://doi.org/10.1016/j.tig.2017.12.010
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
