The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Color me bad: microbial pigments as virulence factors
Open accessAbstract
A hallmark feature of several pathogenic microbes is the distinctive color of their colonies when propagated in the clinical laboratory. Such pigmentation comes in a variety of hues, and has often proven useful in presumptive clinical diagnosis. Recent advances in microbial pigment biochemistry and the genetic basis of pigment production has sometimes revealed a more sinister aspect to these curious materials that change the color of reflected light by selective light absorbance. In many cases, the microbial pigment contributes to disease pathogenesis by interfering with host immune clearance mechanisms or by exhibiting pro-inflammatory or cytotoxic properties. Here, we review several examples of pigments that promote microbial virulence, including the golden staphyloxanthin of Staphylococcus aureus, the blue-green pyocyanin of Pseudomonas spp., and the dark brown or black melanin pigments of Cryptococcus neoformans and Aspergillus spp. Targeted pigment neutralization may represent a viable concept to enhance treatment of certain difficult infectious disease conditions.
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Cites
Liu, G. Y., Essex, A., Buchanan, J. T., Datta, V., Hoffman, H. M., Bastian, J. F., Fierer, J., & Nizet, V. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050846 · Cited by 752
Self-citationCarotenoid radical chemistry and antioxidant/pro-oxidant properties
El-Agamey, A., Lowe, G. M., McGarvey, D. J., Mortensen, A., Phillip, D. M., Truscott, T. G., & Young, A. J. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.007 · Cited by 627
Clauditz, A., Resch, A., Wieland, K.-P., Peschel, A., & Götz, F. (2006) · Infection and Immunity · doi:10.1128/iai.00204-06 · Cited by 509
A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence
Liu, C.-I., Liu, G. Y., Song, Y., Yin, F., Hensler, M. E., Jeng, W.-Y., Nizet, V., Wang, A. H.-J., & Oldfield, E. (2008) · Science · doi:10.1126/science.1153018 · Cited by 490
Self-citationMelanin-lacking mutants of Cryptococcus neoformans and their virulence for mice
Kwon-Chung, K. J., Polacheck, I., & Popkin, T. J. (1982) · Journal of Bacteriology · doi:10.1128/jb.150.3.1414-1421.1982 · Cited by 327
The antibody response to fungal melanin in mice
Nosanchuk, J. D., Rosas, A. L., & Casadevall, A. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.12.6026 · Cited by 92
Cited by
Ludwig, N., Löhrer, M., Hempel, M., Mathea, S., Schliebner, I., Menzel, M., Kiesow, A., Schaffrath, U., Deising, H. B., & Horbach, R. (2014) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi-09-13-0267-r · Cited by 95
An encapsulation of iron homeostasis and virulence in Cryptococcus neoformans
Kronstad, J. W., Hu, G., & Jung, W. H. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.05.007 · Cited by 78
Mechanisms of Pulmonary Escape and Dissemination by Cryptococcus neoformans
Denham, S., & Brown, J. (2018) · Journal of Fungi · doi:10.3390/jof4010025 · Cited by 67
Inhibition of Quorum Sensing and Virulence in Serratia marcescens by Hordenine
Zhou, J.-W., Ruan, L.-Y., Chen, H.-J., Luo, H.-Z., Jiang, H., Wang, J.-S., & Jia, A.-Q. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05922 · Cited by 56
Zhang, C., He, Y., Zhu, P., Chen, L., Wang, Y., Ni, B., & Xu, L. (2015) · Molecular Plant-Microbe Interactions® · doi:10.1094/mpmi-04-15-0085-r · Cited by 47
Metadata
- Authors
- Liu, G. Y., & Nizet, V.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 17
- Issue
- 9
- Pages
- 406-413
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2095967048
- Cited by
- 378
- References
- 6
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
