Carotenoid radical chemistry and antioxidant/pro-oxidant properties
Abstract
The purpose of this review is to summarise the current state of knowledge of (i) the kinetics and mechanisms of radical reactions with carotenoids, (ii) the properties of carotenoid radicals, and (iii) the antioxidant/pro-oxidant properties of carotenoids.
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Carotenoids terminate ROS by mechanisms including hydrogen abstraction, electron transfer, and radical addition.
“The most frequent involve (a) hydrogen abstraction from the carotenoid molecule, (b) electron transfer reaction, and (c) radical addition to carotenoid structure (El-Agamey et al. 2004).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as El-Agamey et al. 2004
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Free radicals and antioxidants in normal physiological functions and human disease
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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Potential Role of Carotenoids as Antioxidants in Human Health and Disease
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Carotenoids: biochemistry, pharmacology and treatment
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β-Carotene Is an Important Vitamin A Source for Humans
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Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases
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Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms
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The cyanobacterial UV-absorbing pigment scytonemin displays radical-scavenging activity
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Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?
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- Authors
- El-Agamey, A., Lowe, G. M., McGarvey, D. J., Mortensen, A., Phillip, D. M., Truscott, T. G., & Young, A. J.
- Affiliations
- Liverpool John Moores University (GB)
- Keele University (GB)
- Chr. Hansen (Denmark) (DK)
- Corresponding author
- McGarvey, David J.
- Mortensen, Alan
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 430
- Issue
- 1
- Pages
- 37-48
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2050781513
- Cited by
- 627
- References
- 118
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 32 · 2023: 30 · 2022: 37 · 2021: 27 · 2020: 50 · 2019: 35 · 2018: 25 · 2017: 38 · 2016: 37 · 2015: 35 · 2014: 27 · 2013: 28 · 2012: 25
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- carotenoids, radical reactions, reaction kinetics, reaction mechanism, antioxidant activity, free radicals
- MeSH terms
- Antioxidants, Carotenoids, Electrochemistry, Models, Molecular, Solvents, Molecular Structure, Oxidants
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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