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Life in the inflamed intestine, Salmonella style
Open accessAbstract
The lower gastrointestinal tract is densely populated with resident microbial communities (microbiota), which do not elicit overt host responses but rather provide benefit to the host, including niche protection from pathogens. However, introduction of bacteria into the underlying tissue evokes acute inflammation. Non-typhoidal Salmonella serotypes (NTS) elicit this stereotypic host response by actively penetrating the intestinal epithelium and surviving in tissue macrophages. Initial responses generated by bacterial host cell interaction are amplified in tissue through the interleukin (IL)-18/interferon-gamma and IL-23/IL-17 axes, resulting in the activation of mucosal barrier functions against NTS dissemination. However, the pathogen is adapted to survive antimicrobial defenses encountered in the lumen of the inflamed intestine. This strategy enables NTS to exploit inflammation to outcompete the intestinal microbiota, and promotes the Salmonella transmission by the fecal/oral route.
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“The non-typhoidal Salmonella (NTS) serovar Salmonella Typhimurium initially colonizes the intestines before invading through Peyer’s patches to reach deeper tissues (Santos et al., 2009).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Santos et al., 2009
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Self-citationSalmonella Typhimurium and inflammation: a pathogen-centric affair
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Metadata
- Authors
- Santos, R. L., Raffatellu, M., Bevins, C. L., Adams, L. G., Tükel, Ç., Tsolis, R. M., & Bäumler, A. J.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- University of California, Irvine (US)
- University of California, Davis (US)
- Texas A&M University (US)
- Corresponding author
- Bäumler, Andreas J.
- ORCID
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 17
- Issue
- 11
- Pages
- 498-506
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC3235402
- OpenAlex
- W2075058732
- Cited by
- 197
- References
- 100
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 12 · 2013: 19 · 2012: 17
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI044170, AI 040124, AI044170, AI079173, R21AI079173, R01AI032738, R29AI040124, R01AI050843, R01AI076246, R01AI040124, R01AI050553, AI050553, AI076246, R37AI032738)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- non-typhoidal Salmonella, intestinal inflammation, host-pathogen interaction, gut microbiota, tissue macrophages, IL-23/IL-17 axis, mucosal barrier, antimicrobial resistance, fecal-oral transmission
- MeSH terms
- Animals, Humans, Intestinal Mucosa, Intestines, Macrophages, Models, Biological, Salmonella, Salmonella Infections, Cytokines
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