Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

Deriu, Elisa; Boxx, Gayle M.; He, Xuesong; Pan, Calvin; Benavidez, Sammy David; Cen, Lujia; Rozengurt, Nora; Shi, Wenyuan; Cheng, Genhong

doi:10.1371/journal.ppat.1005572

Cited by 286Gut microbiota and healthinterferon and immune responsesInfluenza Virus Research Studies

Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

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Deriu, Elisa, Boxx, Gayle M., He, Xuesong, Pan, Calvin, Benavidez, Sammy David, Cen, Lujia, Rozengurt, Nora, Shi, Wenyuan +1 more·2016·PLoS Pathogens

DOI 10.1371/journal.ppat.1005572PMC PMC4858270

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Abstract

Human influenza viruses replicate almost exclusively in the respiratory tract, yet infected individuals may also develop gastrointestinal symptoms, such as vomiting and diarrhea. However, the molecular mechanisms remain incompletely defined. Using an influenza mouse model, we found that influenza pulmonary infection can significantly alter the intestinal microbiota profile through a mechanism dependent on type I interferons (IFN-Is). Notably, influenza-induced IFN-Is produced in the lungs promote the depletion of obligate anaerobic bacteria and the enrichment of Proteobacteria in the gut, leading to a "dysbiotic" microenvironment. Additionally, we provide evidence that IFN-Is induced in the lungs during influenza pulmonary infection inhibit the antimicrobial and inflammatory responses in the gut during Salmonella-induced colitis, further enhancing Salmonella intestinal colonization and systemic dissemination. Thus, our studies demonstrate a systemic role for IFN-Is in regulating the host immune response in the gut during Salmonella-induced colitis and in altering the intestinal microbial balance after influenza infection.

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Using animal models of pulmonary infections by influenza and RSV, multiple groups have shown that the gut microbiome is clearly impacted by respiratory viral infections, despite the lack of detectable respiratory virus in the gut.
“Using animal models of pulmonary infections by influenza and respiratory syncytial virus (RSV), multiple groups have shown that the gut microbiome is clearly impacted by respiratory viral infections, despite the lack of detectable respiratory virus in the gut”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [44]

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Authors: Deriu, E., Boxx, G. M., He, X., Pan, C., Benavidez, S. D., Cen, L., Rozengurt, N., Shi, W., & Cheng, G.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Cheng, Genhong
ORCID: Boxx, Gayle M.
He, Xuesong
Pan, Calvin
Cen, Lujia
Shi, Wenyuan
Cheng, Genhong
Venue: PLoS Pathogens
Publisher: Public Library of Science (PLoS)
Published: 2016-05-05
Volume: 12
Issue: 5
Pages: e1005572
ISSN: 1553-7366 (ISSN-L)
1553-7374
DOI: 10.1371/journal.ppat.1005572
PMC: PMC4858270
OpenAlex: W2345507899
Cited by: 280
References: 68
Citations by year: 2026: 18 · 2025: 23 · 2024: 30 · 2023: 28 · 2022: 44 · 2021: 47 · 2020: 34 · 2019: 14 · 2018: 20 · 2017: 18 · 2016: 4
FWCI: 9.70
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: PLoS Pathogens (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Figshare (cc-by)
Funders: National Institute of Allergy and Infectious Diseases (R01 AI056154, RO1 AI069120)
National Institutes of Health (P30 DK041301)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Keywords: influenza virus, gut microbiota, type I interferon, Salmonella, colitis, dysbiosis, obligate anaerobes, Proteobacteria, intestinal immunity, systemic dissemination
MeSH terms: Gastrointestinal Microbiome, Animals, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Interferon Type I, Mice, Inbred C57BL, Orthomyxoviridae Infections, Salmonella Infections, Animal, Immunoblotting, Mice, Knockout, Mice, Coinfection, Real-Time Polymerase Chain Reaction

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Influenza Virus Affects Intestinal Microbiota and Secondary Salmonella Infection in the Gut through Type I Interferons

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