The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection
Open accessAbstract
Human cytomegalovirus (HCMV) infection causes dramatic alterations of intermediary metabolism, similar to those found in tumor cells. In infected cells, glucose carbon is not completely broken down by the tricarboxylic acid (TCA) cycle for energy; instead it is used biosynthetically. This process requires increased glucose uptake, increased glycolysis and the diversion of glucose carbon, in the form of citrate, from the TCA cycle for use in HCMV-induced fatty acid biosynthesis. The diversion of citrate from the TCA cycle (cataplerosis) requires induction of enzymes to promote glutaminolysis, the conversion of glutamine to -ketoglutarate in order to maintain the TCA cycle (anaplerosis) and ATP production. Such changes could result in heretofore uncharacterized pathogenesis, potentially implicating HCMV as a subtle co-factor in many maladies, including oncogenesis. Recognition of the effects of HCMV, and other viruses, on host cell metabolism will provide new understanding of viral pathogenesis and novel avenues for antiviral therapy.
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Cites
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�ber den Stoffwechsel der Carcinomzelle
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Heaton, N. S., & Randall, G. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.03.007 · Cited by 381
Targeting metabolic reprogramming by influenza infection for therapeutic intervention
Smallwood, H. S., Duan, S., Morfouace, M., Rezinciuc, S., Shulkin, B. L., Shelat, A., Zink, E. E., Milasta, S., Bajracharya, R., Oluwaseum, A. J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.039 · Cited by 171
Metadata
- Authors
- Yu, Y., Clippinger, A. J., & Alwine, J. C.
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 19
- Issue
- 7
- Pages
- 360-367
- ISSN
- 0966-842X (ISSN-L)
- OpenAlex
- W2002640020
- Cited by
- 197
- References
- 9
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, Y., Clippinger, A. J., & Alwine, J. C. (2011). Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends in Microbiology. https://doi.org/10.1016/j.tim.2011.04.002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
