Herpesviruses and their host cells: a successful liaison

Adler, Barbara; Sattler, Christine; Adler, Heiko

doi:10.1016/j.tim.2016.11.009

Cited by 70Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchViral-associated cancers and disorders

Herpesviruses and their host cells: a successful liaison

Adler, Barbara, Sattler, Christine, Adler, Heiko·2017·Trends in Microbiology

DOI 10.1016/j.tim.2016.11.009

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Abstract

During a long history of coevolution, herpesviruses have reached a fine-tuned balance with their hosts, allowing them to successfully persist and spread to new hosts without causing too much damage. Only under certain circumstances, as in neonates or immunocompromised individuals, they may cause serious diseases. The delicate balance between herpesviruses and their hosts results from interactions of a great variety of viral and cellular factors which together shape the tropism for a particular host, tissue, or cell. Understanding these interactions will provide insight into the viral life cycle and cell biology in general. Moreover, it will also facilitate comprehension of herpesvirus pathogenesis, enabling the development of new strategies to combat herpesviruses in cases where they cause disease.

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The portal of entry is not the ultimate goal of herpesviruses, and they need to travel through either blood or nerve to their preferred tissues where they can establish latency or induce disease.
“The portal of entry is not the ultimate goal of herpesviruses, and they need to travel (through either blood or nerve) to their preferred tissues where they can establish latency or induce disease (Adler et al., 2017).”
From Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells (2020) · cites this paper as Adler et al., 2017

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Authors: Adler, B., Sattler, C., & Adler, H.
Affiliations: Max-von-Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie (DE)
Helmholtz Munich (DE)
Corresponding author: Adler, Heiko
ORCID: Adler, Barbara
Adler, Heiko
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 2017-03
Volume: 25
Issue: 3
Pages: 229-241
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/j.tim.2016.11.009
OpenAlex: W2560359096
Cited by: 70
References: 115
Citations by year: 2026: 11 · 2025: 6 · 2024: 5 · 2023: 17 · 2022: 13 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2
FWCI: 0.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: herpesvirus, host-virus interaction, viral tropism, viral persistence, viral pathogenesis, viral life cycle, coevolution, immunocompromised patients, neonatal infection, antiviral strategies
MeSH terms: Herpesviridae, Herpesviridae Infections, Humans, Virus Latency, Virus Internalization, Host-Pathogen Interactions, Viral Tropism

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