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Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

Cazalla, Demián, Yario, Therese, Steitz, Joan A.·2010·Science
DOI 10.1126/science.1187197PMC PMC3075239
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Abstract

Herpes Virus MiRNA Modulation: Viruses use a number of strategies to manipulate the cells of their host to ensure a successful infection. Herpesvirus saimiri (HVS) generates highly conserved small noncoding RNAs HSUR 1 and HSUR 2 , which modulate expression of a number of proteins in infected primate T cells. Cazalla et al. (p. 1563 ; see the Perspective by Pasquinelli ) observed complementarity between HSUR sequences and the seed regions of three different miRNAs—miR-142-3p, miR-27, and miR-16—and found that these HSURs could bind to the miRNAs. Furthermore, the level of mature miR-27 was modulated by binding to HSUR 1 , which targeted the miRNA for degradation.

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  • Under TDMD, the presence of a target mRNA promotes cognate miRNA degradation, often with specific target mRNAs responsible for controlling miRNA decay.

    “Under TDMD, the presence of a target mRNA promotes cognate miRNA degradation, often with specific target mRNAs responsible for controlling miRNA decay (Ameres et al., 2010; Cazalla, Yario, Steitz, & Steitz, 2010; de la Mata et al., 2015; Ghini et al., 2018; Kleaveland, Shi, Stefano, & Bartel, 2018).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Cazalla, Yario, Steitz, & Steitz, 2010

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Research works printed but not linked: 24

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Authors
Cazalla, D., Yario, T., & Steitz, J. A.
Affiliations
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2010-06-18
Volume
328
Issue
5985
Pages
1563-1566
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1187197
PMC
PMC3075239
Cited by
474
References
1
Language
en

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