The adhesin SCF1 mediates Candida auris colonization
Open accessAbstract
Candida auris is an emerging human fungal pathogen that can rapidly spread and cause outbreaks of invasive infections. Santana et al. discovered that a novel surface colonization factor (SCF1), and a conserved adhesin, Iff4109, mediates C. auris colonization on abiotic surfaces, skin, and virulence in vivo.
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C. auris possesses a unique cell wall, adhesin proteins, and colonizing factors to thrive in the skin.
“C. auris possesses a unique cell wall, adhesin proteins, and colonizing factors to thrive in the skin [13, 17, 36]”
C. auris has a unique ability to colonize and persist in human and murine skin long term, resulting in nosocomial transmission and outbreaks of systemic infections.
“Unlike other Candida species, such as Candida albicans, that colonize the intestine, C. auris has a unique ability to colonize and persist in human and murine skin long term, resulting in nosocomial transmission and outbreaks of systemic infections (4–8).”
From Cell aggregation mediated by <i>ACE2</i> deletion in <i>Candida auris</i> modulates fungal colonization and host immune responses in the skin (2024) · cites this paper as [8]
Cites
Key takeaways from the U.S. CDC’s 2019 antibiotic resistance threats report for frontline providers
Kadri, S. S. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004371 · Cited by 292 · see citing works
Sparber, F., De Gregorio, C., Steckholzer, S., Ferreira, F. M., Dolowschiak, T., Ruchti, F., Kirchner, F. R., Mertens, S., Prinz, I., Joller, N., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.02.002 · Cited by 255 · see citing works
Proctor, D. M., Dangana, T., Sexton, D. J., Fukuda, C., Yelin, R. D., Stanley, M., Bell, P. B., Baskaran, S., Deming, C., Chen, Q., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01383-w · Cited by 198 · see citing works
Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin
Horton, M. V., Johnson, C. J., Kernien, J. F., Patel, T. D., Lam, B. C., Cheong, J. Z. A., Meudt, J. J., Shanmuganayagam, D., Kalan, L. R., & Nett, J. E. (2020) · mSphere · doi:10.1128/msphere.00910-19 · Cited by 159 · see citing works
Santana, D. J., Anku, J. A. E., Zhao, G., Zarnowski, R., Johnson, C. J., Hautau, H., Visser, N. D., Ibrahim, A. S., Andes, D., Nett, J. E., et al. (2023) · Science · doi:10.1126/science.adf8972 · Cited by 142 · see citing works
Datta, A., Das, D., Nett, J. E., Vyas, J. M., Lionakis, M. S., & Thangamani, S. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02215-23 · Cited by 30 · see citing works
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Balakumar, A., Das, D., Datta, A., Mishra, A., Bryak, G., Ganesh, S. M., Netea, M. G., Kumar, V., Lionakis, M. S., Arora, D., et al. (2024) · PLOS Pathogens · doi:10.1371/journal.ppat.1012699 · Cited by 25 · see citing works
Self-citationBalakumar, A., Cox, A., & Thangamani, S. (2024) · mSphere · doi:10.1128/msphere.00734-24 · Cited by 12 · see citing works
Self-citation
- Authors
- Balakumar, A., Bernstein, D., & Thangamani, S.
- Affiliations
- Purdue University West Lafayette (US)
- Ball State University (US)
- Corresponding author
- Thangamani, Shankar
- Venue
- Trends in Microbiology
- Publisher
- Elsevier BV
- Published
- 2024-01
- Volume
- 32
- Issue
- 1
- Pages
- 4-5
- ISSN
- 0966-842X (ISSN-L)
- PMC
- PMC10872899
- OpenAlex
- W4388517765
- Cited by
- 11
- References
- 6
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 367 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Trends in Microbiology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (1R01AI177604-01, 1R15AI130950-02)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida auris, adhesins, fungal colonization, surface colonization, abiotic surfaces, skin colonization, virulence, emerging fungal pathogens
- MeSH terms
- Candida auris, Antifungal Agents, Candida, Candidiasis, Humans, Virulence, Adhesins, Bacterial
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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