The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
RNA-binding proteins in neurodegeneration: Seq and you shall receive
Open accessAbstract
As critical players in gene regulation, RNA binding proteins (RBPs) are taking center stage in our understanding of cellular function and disease. In our era of bench-top sequencers and unprecedented computational power, biological questions can be addressed in a systematic, genome-wide manner. Development of high-throughput sequencing (Seq) methodologies provides unparalleled potential to discover new mechanisms of disease-associated perturbations of RNA homeostasis. Complementary to candidate single-gene studies, these innovative technologies may elicit the discovery of unexpected mechanisms, and enable us to determine the widespread influence of the multifunctional RBPs on their targets. Given that the disruption of RNA processing is increasingly implicated in neurological diseases, these approaches will continue to provide insights into the roles of RBPs in disease pathogenesis.
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“The advent of whole genome analyses10,12,188,189 brought a new appreciation of its pervasiveness and regulatory reach in metazoan organisms190,191.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [12]
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Metadata
- Authors
- Nussbacher, J. K., Batra, R., Lagier-Tourenne, C., & Yeo, G. W.
- Affiliations
- University of California San Diego (US)
- National University of Singapore (SG)
- Corresponding author
- Yeo, Gene W.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 38
- Issue
- 4
- Pages
- 226-236
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC4403644
- OpenAlex
- W2170944200
- Cited by
- 115
- References
- 128
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 15 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 14 · 2016: 13 · 2015: 6
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005131)
- National Human Genome Research Institute (HG004659, R01HG004659, U54HG007005)
- National Institute of Neurological Disorders and Stroke (R01NS075449, R01NS087227, NS075449)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- RNA-binding proteins, neurodegeneration, RNA homeostasis, RNA processing, next-generation sequencing, genome-wide characterization, gene expression regulation, pathogenesis
- MeSH terms
- Animals, Humans, RNA Processing, Post-Transcriptional, RNA-Binding Proteins, Neurodegenerative Diseases, High-Throughput Nucleotide Sequencing
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