Cited by 115RNA Research and SplicingAmyotrophic Lateral Sclerosis ResearchGenetics and Neurodevelopmental Disorders

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RNA-binding proteins in neurodegeneration: Seq and you shall receive

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Nussbacher, Julia K., Batra, Ranjan, Lagier-Tourenne, Clotilde, Yeo, Gene W.·2015·Trends in Neurosciences

DOI 10.1016/j.tins.2015.02.003PMC PMC4403644

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Abstract

As critical players in gene regulation, RNA binding proteins (RBPs) are taking center stage in our understanding of cellular function and disease. In our era of bench-top sequencers and unprecedented computational power, biological questions can be addressed in a systematic, genome-wide manner. Development of high-throughput sequencing (Seq) methodologies provides unparalleled potential to discover new mechanisms of disease-associated perturbations of RNA homeostasis. Complementary to candidate single-gene studies, these innovative technologies may elicit the discovery of unexpected mechanisms, and enable us to determine the widespread influence of the multifunctional RBPs on their targets. Given that the disruption of RNA processing is increasingly implicated in neurological diseases, these approaches will continue to provide insights into the roles of RBPs in disease pathogenesis.

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Authors: Nussbacher, J. K., Batra, R., Lagier-Tourenne, C., & Yeo, G. W.
Affiliations: University of California San Diego (US)
National University of Singapore (SG)
Corresponding author: Yeo, Gene W.
ORCID: Nussbacher, Julia K.
Batra, Ranjan
Yeo, Gene W.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2015-04
Volume: 38
Issue: 4
Pages: 226-236
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2015.02.003
PMC: PMC4403644
OpenAlex: W2170944200
Cited by: 115
References: 128
Citations by year: 2026: 6 · 2025: 4 · 2024: 15 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 14 · 2016: 13 · 2015: 6
FWCI: 1.62
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P50AG005131)
National Human Genome Research Institute (HG004659, R01HG004659, U54HG007005)
National Institute of Neurological Disorders and Stroke (R01NS075449, R01NS087227, NS075449)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: RNA-binding proteins, neurodegeneration, RNA homeostasis, RNA processing, next-generation sequencing, genome-wide characterization, gene expression regulation, pathogenesis
MeSH terms: Animals, Humans, RNA Processing, Post-Transcriptional, RNA-Binding Proteins, Neurodegenerative Diseases, High-Throughput Nucleotide Sequencing

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RNA-binding proteins in neurodegeneration: Seq and you shall receive

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