The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The Rise and Fall of the d -Serine-Mediated Gliotransmission Hypothesis
Open accessAbstract
D-Serine modulates NMDA receptors and regulates synaptic plasticity, neurodevelopment, and learning and memory. However, the primary site of D-serine synthesis and release remains controversial, with some arguing that it is a “gliotransmitter” and others defining it as a “neuronal co-transmitter”. Results from several laboratories using different strategies now show that the D-serine’s biosynthetic enzyme, serine racemase (SR), is expressed almost entirely by neurons, with few astrocytes appearing to contain D-serine. Cell-selective suppression of serine racemase expression demonstrates that neuronal, rather than astrocytic D-serine, modulates synaptic plasticity. Here we propose an alternative conceptualization whereby astrocytes affect D-serine levels by synthesizing L-serine that shuttles to neurons to fuel the neuronal synthesis of D-serine.
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Glutamate Receptor Ion Channels: Structure, Regulation, and Function
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Long-term potentiation depends on release of d-serine from astrocytes
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Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Brain Glucose Metabolism: Integration of Energetics with Function
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Glutamate hypothesis in schizophrenia
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Self-citationGoing the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Armada-Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves-Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 317
Deciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282
Metadata
- Authors
- Wolosker, H., Balu, D. T., & Coyle, J. T.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 39
- Issue
- 11
- Pages
- 712-721
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2531811404
- Cited by
- 195
- References
- 14
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
