Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, Mireille; Allaman, Igor; Magistretti, Pierre J.

doi:10.1016/j.cmet.2011.08.016

Cited by 2,313Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismNeuroinflammation and Neurodegeneration Mechanisms

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Open access

Bélanger, Mireille, Allaman, Igor, Magistretti, Pierre J.·2011·Cell Metabolism

DOI 10.1016/j.cmet.2011.08.016

Open this paper in CoChat — free account Open PDF

Abstract

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes-a type of glial cell-have emerged as active players in brain energy delivery, production, utilization, and storage. Our understanding of neuroenergetics is rapidly evolving from a "neurocentric" view to a more integrated picture involving an intense cooperativity between astrocytes and neurons. This review focuses on the cellular aspects of brain energy metabolism, with a particular emphasis on the metabolic interactions between neurons and astrocytes.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2011.08.016

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Secreted ApoE is generally presumed to be converted into HDL-like LNPs by astrocytes.
“As the major lipid carrier in the brain, secreted ApoE is generally presumed to be converted into HDL-like LNPs by astrocytes.”
From ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis (2025) · cites this paper as [47]
These LNPs undergo receptor-mediated endocytosis in neurons and glia cells where their lipid constituents are disassembled in lysosomes to supply these constituents to recipient cells.
“In turn, these LNPs undergo receptor-mediated endocytosis in neurons and glia cells where their lipid constituents are disassembled in lysosomes to supply these constituents to the recipient cells.22, 44–47”
From ApoE is Secreted as a Lipid Nanoparticle by Mammalian Cells: Implications for Alzheimer’s Disease Pathogenesis (2025) · cites this paper as [47]
Astrocytes provide critical support to neurons for synapse formation/pruning, neurotransmitter modulation, and metabolic homeostasis.
“Astrocytes provide critical support to neurons for synapse formation/pruning, neurotransmitter modulation, and metabolic homeostasis (Bélanger et al., 2011; Jha and Morrison, 2018).”
From ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism (2021) · cites this paper as Bélanger et al., 2011
Neuronal cells in the brain have a particularly high metabolism, using 20% and 25% of total consumed oxygen and glucose, making neurons and their mitochondria particularly susceptible to ROS damage.
“Neuronal cells in the brain have a particularly high metabolism, using 20% and 25% of the total consumed oxygen and glucose,34 this makes neurons and their mitochondria particularly susceptible to ROS damage.”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [34]

THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000 · see citing works
Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
Ogawa, S., Tank, D. W., Menon, R., Ellermann, J. M., Kim, S. G., Merkle, H., & Ugurbil, K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5951 · Cited by 3,681 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · cited 2× · see citing works
“The stimulation of astrocytic glucose utilization by glutamate was subsequently confirmed by several independent groups (reviewed in Pellerin et al., 2007; Barros and Deitmer, 2010).”
BackgroundSelf-citation
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511 · see citing works
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056 · see citing works
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796 · see citing works
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Self-citation
Metabolism and functions of glutathione in brain
Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702 · see citing works
BRAIN WORK AND BRAIN IMAGING
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works
Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2002) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,446 · see citing works
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · see citing works
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works
Astrocyte-mediated control of cerebral blood flow
Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137 · see citing works
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114 · see citing works
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
Davison, A. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.8.1021-a · Cited by 949 · see citing works
Calcium transients in astrocyte endfeet cause cerebrovascular constrictions
Mulligan, S. J., & MacVicar, B. A. (2004) · Nature · doi:10.1038/nature02827 · Cited by 872 · see citing works
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 861 · see citing works
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812 · see citing works
Activity-dependent regulation of energy metabolism by astrocytes: an update
Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805 · see citing works
Self-citation
Cell–cell and intracellular lactate shuttles
Brooks, G. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178350 · Cited by 803 · see citing works
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress
Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 786 · see citing works
Astroglial networks: a step further in neuroglial and gliovascular interactions
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2757 · Cited by 781 · see citing works
Synaptic Islands Defined by the Territory of a Single Astrocyte
Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767 · see citing works
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742 · see citing works
Brain metabolism dictates the polarity of astrocyte control over arterioles
Gordon, G. R., Choi, H. B., Rungta, R. L., Ellis‐Davies, G. C. R., & MacVicar, B. A. (2008) · Nature · doi:10.1038/nature07525 · Cited by 739 · see citing works
Astrocytic complexity distinguishes the human brain
Oberheim, N. A., Wang, X., Goldman, S., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.004 · Cited by 739 · see citing works
Circulation and Energy Metabolism of the Brain
Clarke, D. D., & Sokoloff, L. (1999) · Cited by 672 · see citing works
Astrocyte–neuron metabolic relationships: for better and for worse
Allaman, I., Bélanger, M., & Magistretti, P. J. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2010.12.001 · Cited by 639 · see citing works
Self-citation
Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling
Metea, M. R., & Newman, E. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4048-05.2006 · Cited by 637 · see citing works
Astrocyte glycogen and brain energy metabolism
Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626 · see citing works
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard, J. W., Rothman, D. L., Novotny, E. J., Petroff, O. A. C., Kuwabara, T., Avison, M. J., Howseman, A., Hanstock, C. C., & Shulman, R. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5829 · Cited by 612 · see citing works
Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer’s Disease
Mosconi, L., Pupi, A., & de Leon, M. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 605 · see citing works
Energetic basis of brain activity: implications for neuroimaging
Shulman, R. G., Rothman, D. L., Behar, K. L., & Hyder, F. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.005 · Cited by 590 · see citing works
Glycogen in astrocytes: possible function as lactate supply for neighboring cells
Dringen, R., Gebhardt, R., & Hamprecht, B. (1993) · Brain Research · doi:10.1016/0006-8993(93)91429-v · Cited by 536 · see citing works
Blood lactate is an important energy source for the human brain.
van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.35 · Cited by 522 · see citing works
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway
Almeida, Á., Moncada, S., & Bolaños, J. P. (2003) · Nature Cell Biology · doi:10.1038/ncb1080 · Cited by 481 · see citing works
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Tsujino, N., & Sakurai, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001321 · Cited by 479 · see citing works
Antioxidant defense of the brain: a role for astrocytes
Wilson, J. X. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-146 · Cited by 430 · see citing works
Energy-Efficient Action Potentials in Hippocampal Mossy Fibers
Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429 · see citing works
Different Responses of Astrocytes and Neurons to Nitric Oxide: The Role of Glycolytically Generated ATP in Astrocyte Protection
Almeida, A., Almeida, J., Bolaños, J. P., & Moncada, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261560998 · Cited by 423 · see citing works
Fundamental neuroscience
McCandless, D. W. (1997) · Metabolic Brain Disease · doi:10.1007/bf02676357 · Cited by 423 · see citing works
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408 · see citing works
The role of astroglia in neuroprotection
Bélanger, M., & Magistretti, P. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/mbelanger · Cited by 396 · see citing works
Self-citation
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385 · see citing works
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Vı́lchez, D., R�os, S., Cifuentes, D., Pujadas, L., Vallès, J., García-Fojeda, B., Criado‐García, O., Fernández-Sánchez, E., Medraño-Fernández, I., Domínguez, J. E., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1998 · Cited by 374 · see citing works
Astroglial Contribution to Brain Energy Metabolism in Humans Revealed by13C Nuclear Magnetic Resonance Spectroscopy: Elucidation of the Dominant Pathway for Neurotransmitter Glutamate Repletion and Measurement of Astrocytic Oxidative Metabolism
Lebon, V., Petersen, K. F., Cline, G. W., Shen, J., Mason, G. F., Dufour, S., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01523.2002 · Cited by 371 · see citing works
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy
Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-10.2010 · Cited by 362 · see citing works
Glycolysis: a bioenergetic or a survival pathway?
Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 359 · see citing works
Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.
Magistretti, P. J., Morrison, J. H., Shoemaker, W. J., Sapin, V., & Bloom, F. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6535 · Cited by 351 · see citing works
Self-citation
Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism
Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341 · see citing works
A Temporary Local Energy Pool Coupled to Neuronal Activity: Fluctuations of Extracellular Lactate Levels in Rat Brain Monitored with Rapid‐Response Enzyme‐Based Sensor
Hu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337 · see citing works
Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis
Chih, C.-P., & Roberts, E. L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000081369.51727.6f · Cited by 325 · see citing works
Brain glycogen re-awakened
Brown, A. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02421.x · Cited by 308 · see citing works
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 304 · see citing works
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297 · see citing works
An Increase in Lactate Output by Brain Tissue Serves to Meet the Energy Needs of Glutamate-Activated Neurons
Schurr, A., Miller, J. J., Payne, R. S., & Rigor, B. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00034.1999 · Cited by 295 · see citing works
Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293 · see citing works
Self-citation
The Nrf2–ARE cytoprotective pathway in astrocytes
Vargas, M. R., & Johnson, J. A. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409001094 · Cited by 289 · see citing works
Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo
Smith, D., Pernet, A., Hallett, W. A., Bingham, E., Marsden, P. K., & Amiel, S. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000063991.19746.11 · Cited by 282 · see citing works
Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus
Witcher, M. R., Kirov, S. A., & Harris, K. M. (2006) · Glia · doi:10.1002/glia.20415 · Cited by 281 · see citing works
Amyloid-β Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability
Allaman, I., Gavillet, M., Bélanger, M., Laroche, T., Viertl, D., Lashuel, H. A., & Magistretti, P. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5098-09.2010 · Cited by 277 · see citing works
Self-citation
Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
Bouzier‐Sore, A., Voisin, P., Bouchaud, V., Bezancon, E., Franconi, J., & Pellerin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05056.x · Cited by 265 · see citing works
Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation
Schurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010423.x · Cited by 262 · see citing works
Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism
Chen, Y., Vartiainen, N. E., Ying, W., Chan, P. H., Koıstınaho, J., & Swanson, R. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00374.x · Cited by 252 · see citing works
Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens
Gibbs, M. E., Anderson, D. G., & Hertz, L. (2006) · Glia · doi:10.1002/glia.20377 · Cited by 251 · see citing works
Cellular Bases of Brain Energy Metabolism and Their Relevance to Functional Brain Imaging: Evidence for a Prominent Role of Astrocytes
Magistretti, P. J., & Pellerin, L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.50 · Cited by 243 · see citing works
Self-citation
Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy
Boumezbeur, F., Mason, G. F., de Graaf, R. A., Behar, K. L., Cline, G. W., Shulman, G. I., Rothman, D. L., & Petersen, K. F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.197 · Cited by 238 · see citing works
Sensory stimulation induces local cerebral glycogenolysis: Demonstration by autoradiography
Swanson, R. A., Morton, M. M., Sagar, S. M., & Sharp, F. R. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90329-z · Cited by 237 · see citing works
The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
Figley, C. R., & Stroman, P. W. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07584.x · Cited by 232 · see citing works
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224 · see citing works
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0762-10.2010 · Cited by 217 · see citing works
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.
Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213 · see citing works
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
Gallagher, C., Carpenter, K. L. H., Grice, P., Howe, D. J., Mason, A., Timofeev, I. S., Menon, D. K., Kirkpatrick, P. J., Pickard, J. D., Sutherland, G. R., et al. (2009) · Brain · doi:10.1093/brain/awp202 · Cited by 201 · see citing works
Astrocytes : pharmacology and function
Murphy, S. P. (1993) · Cited by 198 · see citing works
Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles
Hashimoto, T., Hussien, R., Cho, H.-S., Kaufer, D., & Brooks, G. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002915 · Cited by 196 · see citing works
Glial Nax Channels Control Lactate Signaling to Neurons for Brain [Na+] Sensing
Shimizu, H., Watanabe, E., Hiyama, T. Y., Nagakura, A., Fujikawa, A., Okado, H., Yanagawa, Y., Obata, K., & Noda, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.014 · Cited by 196 · see citing works
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels
Ainscow, E., Mirshamsi, S., Tang, T., Ashford, M. L. J., & Rutter, G. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022434 · Cited by 194 · see citing works
The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Mangia, S., Simpson, I. A., Vannucci, S. J., & Carruthers, A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06003.x · Cited by 189 · see citing works
Assessment of the Role of the Glutathione and Pentose Phosphate Pathways in the Protection of Primary Cerebrocortical Cultures from Oxidative Stress
Ben‐Yoseph, O., Boxer, P. A., & Ross, B. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062329.x · Cited by 189 · see citing works
Brain uptake and metabolism of ketone bodies in animal models
Nehlig, A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.07.006 · Cited by 185 · see citing works
A mouse model for Glut-1 haploinsufficiency
Wang, D., Pascual, J. M., Yang, H., Engelstad, K., Mao, X., Cheng, J., Yoo, J. H., Noebels, J. L., & Vivo, D. C. D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl032 · Cited by 185 · see citing works
Role of glutamate in neuron-glia metabolic coupling
Magistretti, P. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27462cc · Cited by 178 · see citing works
Self-citation
Astrocytes generate Na + -mediated metabolic waves
Bernardinelli, Y., Magistretti, P. J., & Chatton, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405315101 · Cited by 178 · see citing works
Self-citation
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
Halim, N. D., Mcfate, T., Mohyeldin, A., Okagaki, P., Korotchkina, L. G., Patel, M. S., Jeoung, N. H., Harris, R. A., Schell, M. J., & Verma, A. (2010) · Glia · doi:10.1002/glia.20996 · Cited by 177 · see citing works
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169 · see citing works
The contribution of astrocyte signalling to neurovascular coupling
Carmignoto, G., & Gómez‐Gonzalo, M. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.007 · Cited by 168 · see citing works
Peroxynitrite Protects Neurons against Nitric Oxide-mediated Apoptosis
Garcı́a-Nogales, P., Almeida, Á., & Bolaños, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206835200 · Cited by 165 · see citing works
Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
Kasischke, K. A., Lambert, E. M., Panepento, B., Sun, A., Gelbard, H. A., Burgess, R. W., Foster, T. H., & Nedergaard, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.158 · Cited by 160 · see citing works
Brain Energy Metabolism
Magistretti, P. J., & Allaman, I. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_56 · Cited by 160 · see citing works
Self-citation
High resolution measurement of the glycolytic rate
Bittner, C. X. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00026 · Cited by 151 · see citing works
Developmental changes in the Ca2+-regulated mitochondrial aspartate–glutamate carrier aralar1 in brain and prominent expression in the spinal cord
Ramos, M., del Arco, A., Pardo, B., Martı́nez-Serrano, A., Martínez‐Morales, J. R., Kobayashi, K., Yasuda, T., Bogónez, E., Bovolenta, P., Saheki, T., et al. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00097-x · Cited by 150 · see citing works
Metabolic Regulation of the Pancreatic Beta-Cell ATP-Sensitive K+ Channel
Tarasov, A. I., Dusonchet, J., & Ashcroft, F. M. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s113 · Cited by 148 · see citing works
Glucose and lactate supply to the synapse
Barros, L. F., & Deitmer, J. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.002 · Cited by 148 · see citing works
A metabolic switch in brain: glucose and lactate metabolism modulation by ascorbic acid
Castro, M. A., Beltrán, F. A., Brauchi, S. E., & Concha, I. I. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06151.x · Cited by 147 · see citing works
The redox switch/redox coupling hypothesis
Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146 · see citing works
Activity‐induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow
Offenhauser, N., Thomsen, K., Caesar, K., & Lauritzen, M. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.082776 · Cited by 143 · see citing works
Functional receptors for vasoactive intestinal polypeptide in cultured astroglia from neonatal rat brain
Magistretti, P. J., Manthorpe, M., Bloom, F. E., & Varon, S. S. (1983) · Regulatory Peptides · doi:10.1016/0167-0115(83)90136-2 · Cited by 140 · see citing works
Self-citation
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139 · see citing works
Lactate, not pyruvate, is neuronal aerobic glycolysis end product: An in vitro electrophysiological study
Schurr, A., & Payne, R. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.002 · Cited by 138 · see citing works
ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal
Parsons, M. P., & Hirasawa, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5741-09.2010 · Cited by 134 · see citing works
Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents
Walls, A. B., Heimbürger, C. M., Bouman, S. D., Schousboe, A., & Waagepetersen, H. S. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.058 · Cited by 133 · see citing works
Astrocytes: Pharmacology and Function
Kettenmann, H. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90080-9 · Cited by 133 · see citing works
13C MR Spectroscopy Study of Lactate as Substrate for Rat Brain
Qu, H., Haberg, A. K., Haraldseth, O., Unsgård, G., & Sonnewald, U. (2000) · Developmental Neuroscience · doi:10.1159/000017472 · Cited by 132 · see citing works
A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover
Dienel, G. A., Ball, K. K., & Cruz, N. F. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04595.x · Cited by 127 · see citing works
Temporal dynamics of the partial pressure of brain tissue oxygen during functional forepaw stimulation in rats
Ances, B. M., Buerk, D. G., Greenberg, J. H., & Detre, J. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01868-7 · Cited by 122 · see citing works
Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte–Neuron Lactate-Shuttle Hypothesis
Erlichman, J. S., Hewitt, A. J., Damon, T., Hart, M. P., Kurascz, J., Li, A., & Leiter, J. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5430-07.2008 · Cited by 121 · see citing works
Functional significance of brain glycogen in sustaining glutamatergic neurotransmission
Sickmann, H. M., Walls, A. B., Schousboe, A., Bouman, S. D., & Waagepetersen, H. S. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05915.x · Cited by 116 · see citing works
Direct measurement of oxidative metabolism in the living brain by microdialysis: a review
Zielke, H. R., Zielke, C. L., & Baab, P. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05941.x · Cited by 116 · see citing works
Mitochondrial transport proteins of the brain
Berkich, D. A., Ola, M. S., Cole, J., Sweatt, A. J., Hutson, S. M., & LaNoue, K. F. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21500 · Cited by 114 · see citing works
Selective Uptake of [ 14 C]2-Deoxyglucose by Neurons and Astrocytes: High-Resolution Microautoradiographic Imaging by Cellular 14 C-Trajectography Combined with Immunohistochemistry
Nehlig, A., Wittendorp-Rechenmann, E., & Dao Lam, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000128533.84196.d8 · Cited by 111 · see citing works
CNS Regulation of Glucose Homeostasis
Lam, C., Chari, M., & Lam, T. K. T. (2009) · Physiology · doi:10.1152/physiol.00003.2009 · Cited by 110 · see citing works
The aerobic brain: lactate decrease at the onset of neural activity
Mangia, S., Garreffa, G., Bianciardi, M., Giove, F., Salle, F. D., & Maraviglia, B. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00792-3 · Cited by 107 · see citing works
The Metabolism of [3‐13C]Lactate in the Rat Brain Is Specific of a Pyruvate Carboxylase‐Deprived Compartment
Bouzier‐Sore, A., Thiaudière, E., Biran, M., Rouland, R., Canioni, P., & Merle, M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750480.x · Cited by 105 · see citing works
Changes in Glucose Uptake Rather than Lactate Shuttle Take Center Stage in Subserving Neuroenergetics: Evidence from Mathematical Modeling
DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.232 · Cited by 93 · see citing works
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson, N. R., Shen, J., Mason, G. F., Rothman, D. L., Behar, K. L., & Shulman, R. G. (1998) · Developmental Neuroscience · doi:10.1159/000017327 · Cited by 92 · see citing works
Local Injection of Antisense Oligonucleotides Targeted to the Glial Glutamate Transporter GLAST Decreases the Metabolic Response to Somatosensory Activation
Cholet, N., Pellerin, L., Welker, E., Lacombe, P. M., Seylaz, J., Magistretti, P. J., & Bonvento, G. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00009 · Cited by 90 · see citing works
Self-citation
Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes
Magistretti, P. J., & Chatton, J. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0171-6 · Cited by 88 · see citing works
Self-citation
Regulation of Glycogen Metabolism in Astrocytes: Physiological, Pharmacological, and Pathological Aspects
Magistretti, P. J., Sorg, O., & Martin, J. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-511370-0.50015-1 · Cited by 84 · see citing works
Self-citation
Comment on Recent Modeling Studies of Astrocyte–Neuron Metabolic Interactions
Jolivet, R., Allaman, I., Pellerin, L., Magistretti, P. J., & Weber, B. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.132 · Cited by 84 · see citing works
Self-citation
Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: A multiphoton study of cerebellar slices
Barros, L. F., Courjaret, R. J., Jakoby, P., Loaiza, A., Lohr, C., & Deitmer, J. W. (2008) · Glia · doi:10.1002/glia.20820 · Cited by 83 · see citing works
Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase
Laughton, J. D., Bittar, P. G., Charnay, Y., Pellerin, L., Kövari, E., Magistretti, P. J., & Bouras, C. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-35 · Cited by 77 · see citing works
Self-citation
Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
Stuart, C. A., Ross, I. R., Howell, M. E. A., McCurry, M. P., Wood, T. G., Ceci, J. D., Kennel, S. J., & Wall, J. S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.014 · Cited by 49 · see citing works
Ex vivo NMR study of lactate metabolism in rat brain under various depressed states
Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20277 · Cited by 43 · see citing works
Neuronal functions, feeding behavior, and energy balance inSlc2a3+/−mice
Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90491.2008 · Cited by 34 · see citing works
The effect of glycogen phosphorolysis on basal glutaminergic transmission
Mozrzymas, J. W., Szczęsny, T. J., & Rakus, D. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.033 · Cited by 27 · see citing works
Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT‐1
Hérard, A., Dubois, A., Escartin, C., Tanaka, K., Delzescaux, T., Hantraye, P., & Bonvento, G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04346.x · Cited by 23 · see citing works
Untitled work
(1998) · doi:10.1002/(sici)1098-1136(199805)23:1

Flagged first, then by citations

1 of the 135 references couldn’t be matched to a known paper.

Sorted by citations

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
“…because the primary energy consumers in the brain, neurons and astrocytes, each exhibit diametric patterns of glucose consumption (for review, see Bélanger et al., 2011; Bouzier-Sore and Pellerin, 2013); neurons heavily rely on oxidative metabolism, whereas astrocytes exhibit high glycolytic…”
Background
Physiology of Astroglia
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576 · see citing works
The Science and Translation of Lactate Shuttle Theory
Brooks, G. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.008 · Cited by 1,486 · see citing works
Ferroptosis: Mechanisms and links with diseases
Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471 · see citing works
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285 · see citing works
Self-citation
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review)
Zheng, J. (2012) · Oncology Letters · doi:10.3892/ol.2012.928 · Cited by 953 · see citing works
Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B. H., Quintana, A., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.019 · Cited by 876 · see citing works
Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works
Lactate as a fulcrum of metabolism
Brooks, G. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101454 · Cited by 724 · see citing works
Function and therapeutic value of astrocytes in neurological diseases
Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works
Molecular pathophysiology of cerebral edema
Stokum, J. A., Gerzanich, V., & Simard, J. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15617172 · Cited by 596 · see citing works
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580 · see citing works
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571 · see citing works
Self-citation
The role of mitochondria in amyotrophic lateral sclerosis
Smith, E. F., Shaw, P. J., & Vos, K. J. D. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.052 · Cited by 556 · see citing works
The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D
Liu, L., MacKenzie, K. R., Putluri, N., Maletić-Savatić, M., & Bellen, H. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.024 · Cited by 556 · see citing works
Methylglyoxal, the dark side of glycolysis
Allaman, I., Bélanger, M., & Magistretti, P. J. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00023 · Cited by 551 · see citing works
Self-citation
The Indispensable Roles of Microglia and Astrocytes during Brain Development
Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516 · see citing works
Neuroprotective Effect of Antioxidants in the Brain
Lee, K. H., Cha, M., & Lee, B. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197152 · Cited by 527 · see citing works
The endocannabinoid system in guarding against fear, anxiety and stress
Lutz, B., Marsicano, G., Maldonado, R., & Hillard, C. J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4036 · Cited by 506 · see citing works
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504 · see citing works
Self-citation
Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio
Tantama, M., Martínez‐François, J. R., Mongeon, R., & Yellen, G. (2013) · Nature Communications · doi:10.1038/ncomms3550 · Cited by 486 · see citing works
Modeling Alzheimer’s disease with iPSC-derived brain cells
Penney, J., Ralvenius, W. T., & Tsai, L.-H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0468-3 · Cited by 471 · see citing works
Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake
Díaz-García, C. M., Mongeon, R., Lahmann, C., Koveal, D., Zucker, H., & Yellen, G. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.021 · Cited by 466 · see citing works
“…an ‘‘astrocyte-neuron lactate shuttle’’ (ANLS), which proposes that astrocytes are stimulated by neuronal glutamate release to convert more glucose to lactate, which is then Cell released by the astrocytes to serve as fuel for the neighboring neurons (Bélanger et al., 2011; Pellerin et al., 1998).”
Elusive roles for reactive astrocytes in neurodegenerative diseases
Ben Haim, L., Carrillo-de Sauvage, M.-A., CeyzÃ©riat, K., & Escartin, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00278 · Cited by 453 · see citing works
Isolation and Culture of Mouse Cortical Astrocytes
Schildge, S., Bohrer, C., Beck, K., & Schachtrup, K. (2013) · Journal of Visualized Experiments · doi:10.3791/50079 · Cited by 453 · see citing works
Lactate metabolism: historical context, prior misinterpretations, and current understanding
Ferguson, B. S., Rogatzki, M. J., Goodwin, M. L., Kane, D. A., Rightmire, Z. B., & Gladden, L. B. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3795-6 · Cited by 451 · see citing works
Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain
Schönfeld, P., & Reiser, G. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.128 · Cited by 457 · see citing works
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes
Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.034 · Cited by 441 · see citing works
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
Maoz, B. M., Herland, A., Fitzgerald, E. A., Grevesse, T., Vidoudez, C., Pacheco, A. R., Sheehy, S. P., Park, T., Dauth, S., Mannix, R. J., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4226 · Cited by 428 · see citing works
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
Brandebura, A. N., Paumier, A., Onur, T. S., & Allen, N. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-022-00641-1 · Cited by 427 · see citing works
Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants
Houldsworth, A. (2023) · Brain Communications · doi:10.1093/braincomms/fcad356 · Cited by 442 · see citing works
Targeting LDH enzymes with a stiripentol analog to treat epilepsy
Sada, N., Lee, S., Katsu, T., Otsuki, T., & Inoue, T. (2015) · Science · doi:10.1126/science.aaa1299 · Cited by 413 · see citing works
Neuroprotective action of resveratrol
Bastianetto, S., Ménard, C., & Quirion, R. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.011 · Cited by 411 · see citing works
Energy metabolism in health and diseases
Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works
Cerebral blood flow and autoregulation: current measurement techniques and prospects for noninvasive optical methods
Fantini, S., Sassaroli, A., Tgavalekos, K. T., & Kornbluth, J. A. (2016) · Neurophotonics · doi:10.1117/1.nph.3.3.031411 · Cited by 400 · see citing works
Mental workload and neural efficiency quantified in the prefrontal cortex using fNIRS
Causse, M., Chua, Z. K., Peysakhovich, V., del Campo, N., & Matton, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-05378-x · Cited by 402 · see citing works
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7807 · Cited by 381 · see citing works
ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
Qi, G., Mi, Y., Shi, X., Gu, H., Brinton, R. D., & Yin, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108572 · Cited by 379 · see citing works
A genetically encoded FRET lactate sensor and its use to detect the Warburg effect in single cancer cells
San Martín, A., Ceballo, S., Ruminot, I., Lerchundi, R., Frommer, W. B., & Barros, L. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057712 · Cited by 361 · see citing works
Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection
Slupe, A. M., & Kirsch, J. R. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18789273 · Cited by 363 · see citing works
Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets
Bi, J., Chowdhry, S., Wu, S., Zhang, W., Masui, K., & Mischel, P. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0226-5 · Cited by 348 · see citing works
The physics of functional magnetic resonance imaging (fMRI)
Buxton, R. B. (2013) · Reports on Progress in Physics · doi:10.1088/0034-4885/76/9/096601 · Cited by 342 · see citing works
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
Kim, J. G., Suyama, S., Koch, M., Jin, S., Argente-Arizon, P., Argente, J., Liu, Z.-W., Zimmer, M. R., Jeong, J. K., Szigeti-Buck, K., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3725 · Cited by 336 · see citing works
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.016 · Cited by 332 · see citing works
Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression
Wang, R., Li, B., Lam, S. M., & Shui, G. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.11.009 · Cited by 339 · see citing works
Morphological, cellular and molecular basis of brain infection in COVID-19 patients
Crunfli, F., Carregari, V. C., Veras, F. P., Vendramini, P. H., Valença, A. G. F., Antunes, A. S. L. M., Brandão-Teles, C., da Silva Zuccoli, G., Reis-de-Oliveira, G., Silva-Costa, L. C., et al. (2020) · doi:10.1101/2020.10.09.20207464 · Cited by 331 · see citing works
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
Milković, L., Gašparović, A. Č., Cindrić, M., Mouthuy, P., & Žarković, N. (2019) · Cells · doi:10.3390/cells8080793 · Cited by 330 · see citing works
Mitochondrial complex I ROS production and redox signaling in hypoxia
Okoye, C. N., Koren, S. A., & Wojtovich, A. P. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102926 · Cited by 328 · see citing works
Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
Persson, T., Popescu, B. O., & Cedazo-Mı́nguez, Á. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/427318 · Cited by 318 · see citing works
CNS Infection and Immune Privilege
Forrester, J. V., McMenamin, P. G., & Dando, S. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0070-8 · Cited by 313 · see citing works
Vascular Cognitive Impairment (VCI)
Rundek, T., Tolea, M. I., Ariko, T., Fagerli, E. A., & Camargo, C. J. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01170-y · Cited by 325 · see citing works
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
Andrabi, S. A., Umanah, G. K. E., Chang, C., Stevens, D. A., Karuppagounder, S. S., Gagné, J.-P., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405158111 · Cited by 307 · see citing works
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 302 · see citing works
Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives
Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 309 · see citing works
Self-citation
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
Beckervordersandforth, R., Ebert, B., Schäffner, I., Moss, J., Fiebig, C., Shin, J., Moore, D. L., Ghosh, L., Trinchero, M. F., Stockburger, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.017 · Cited by 303 · see citing works
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Bisht, K., Okojie, K. A., Sharma, K. P., Lentferink, D. H., Sun, Y., Chen, H., Uweru, J. O., Amancherla, S., Calcuttawala, Z., Campos-Salazar, A. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25590-8 · Cited by 296 · see citing works
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312 · see citing works
The metabolic basis of epilepsy
Rho, J. M., & Boison, D. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00651-8 · Cited by 300 · see citing works
Glymphatic clearance controls state-dependent changes in brain lactate concentration
Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R., & Nedergaard, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16661202 · Cited by 299 · see citing works
Selenium, selenoproteins and neurodegenerative diseases
Cardoso, B. R., Roberts, B. R., Bush, A. I., & Hare, D. J. (2015) · Metallomics · doi:10.1039/c5mt00075k · Cited by 295 · see citing works
Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions
Agnihotri, S., & Zadeh, G. M. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov125 · Cited by 294 · see citing works
Immunometabolism in the Brain: How Metabolism Shapes Microglial Function
Bernier, L., York, E. M., & MacVicar, B. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.008 · Cited by 295 · see citing works
White matter astrocytes in health and disease
Lundgaard, I., Osório, M. J., Kress, B. T., Sanggaard, S., & Nedergaard, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.050 · Cited by 287 · see citing works
α-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading
Loría, F., Vargas, J., Bousset, L., Syan, S., Salles, A., Melki, R., & Zurzolo, C. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1746-2 · Cited by 278 · see citing works
Astrocyte glycogen and lactate: New insights into learning and memory mechanisms
Alberini, C. M., Cruz, E., Descalzi, G., Bessières, B., & Gao, V. (2017) · Glia · doi:10.1002/glia.23250 · Cited by 286 · see citing works
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., et al. (2020) · Molecular Systems Biology · doi:10.15252/msb.20199356 · Cited by 286 · see citing works
Glutathione peroxidase 4: a new player in neurodegeneration?
Cardoso, B. R., Hare, D. J., Bush, A. I., & Roberts, B. R. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.196 · Cited by 281 · see citing works
A review for dynamics of collective behaviors of network of neurons
Ma, J., & Tang, J. (2015) · Science China Technological Sciences · doi:10.1007/s11431-015-5961-6 · Cited by 277 · see citing works
Lactate as a Metabolite and a Regulator in the Central Nervous System
Proia, P., Liegro, C. M. D., Schiera, G., Fricano, A., & Liegro, I. D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091450 · Cited by 280 · see citing works
Glucose, lactate, and shuttling of metabolites in vertebrate retinas
Hurley, J. B., Lindsay, K. J., & Du, J. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23583 · Cited by 275 · see citing works
Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and Alzheimer's Mouse Brain: Implication for Bioenergetic Intervention
Ding, F., Yao, J., Rettberg, J. R., Chen, S., & Brinton, R. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079977 · Cited by 274 · see citing works
Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages
Neth, B., & Craft, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00345 · Cited by 263 · see citing works
Optical imaging of metabolic dynamics in animals
Shi, L., Zheng, C., Shen, Y., Chen, Z., Silveira, E. S., Zhang, L., Wei, M., Liu, C., de Sena-Tomás, C., Targoff, K. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05401-3 · Cited by 271 · see citing works
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
Ajoolabady, A., Lindholm, D., Ren, J., & Pratico, D. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05153-5 · Cited by 261 · see citing works
Glycolytic enzymes localize to synapses under energy stress to support synaptic function
Jang, S., Nelson, J. C., Bend, E. G., Rodríguez-Laureano, L., Tueros, F. G., Cartagenova, L., Underwood, K., Jorgensen, E. M., & Colón-Ramos, D. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.011 · Cited by 270 · see citing works
Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease
Rangaraju, V., Lewis, T. L., Hirabayashi, Y., Bergami, M., Motori, E., Cartoni, R., Kwon, S., & Courchet, J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-19.2019 · Cited by 257 · see citing works
mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP
Hu, Y., Mai, W., Chen, L., Cao, K., Zhang, B., Zhang, Z., Liu, Y., Lou, H., Duan, S., & Gao, Z. (2019) · Glia · doi:10.1002/glia.23760 · Cited by 256 · see citing works
Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance
Motori, E., Puyal, J., Toni, N., Ghanem, A., Angeloni, C., Malaguti, M., Cantelli-Forti, G., Berninger, B., Conzelmann, K.-K., Götz, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.005 · Cited by 249 · see citing works
Lipid and Lipoprotein Metabolism in Microglia
Loving, B. A., & Bruce, K. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00393 · Cited by 255 · see citing works
Oligodendroglia: metabolic supporters of axons
Morrison, B. M., Lee, Y., & Rothstein, J. D. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.007 · Cited by 252 · see citing works
OXPHOS mutations and neurodegeneration
Koopman, W. J. H., Distelmaier, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.300 · Cited by 254 · see citing works
Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic Metal Exposure: Redox Signaling and Oxidative Stress
Garza-Lombó, C., Posadas, Y., Quintanar, L., Gonsebatt, M. E., & Franco, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7272 · Cited by 254 · see citing works
Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy
Zois, C. E., & Harris, A. L. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1377-9 · Cited by 250 · see citing works
Epilepsy and astrocyte energy metabolism
Boison, D., & Steinhäuser, C. (2017) · Glia · doi:10.1002/glia.23247 · Cited by 253 · see citing works
The pathological role of ferroptosis in ischemia/reperfusion-related injury
Yan, H.-F., Tuo, Q., Yin, Q., & Lei, P. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.042 · Cited by 247 · see citing works
Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids
McMurtrey, R. J. (2015) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2015.0375 · Cited by 248 · see citing works
Lactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond
Mason, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00043 · Cited by 240 · see citing works
Brain fluorodeoxyglucose (FDG) PET in dementia
Kato, T., Inui, Y., Nakamura, A., & Ito, K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.003 · Cited by 236 · see citing works
The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders
Missiroli, S., Genovese, I., Perrone, M., Vezzani, B., Vitto, V. A. M., & Giorgi, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030740 · Cited by 231 · see citing works
Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes
Baxter, P. S., & Hardingham, G. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.027 · Cited by 235 · see citing works
Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role
Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
Base excision repair of oxidative DNA damage from mechanism to disease
Freudenthal, B. (2017) · Frontiers in bioscience · doi:10.2741/4555 · Cited by 230 · see citing works
Insulin Resistance in Alzheimer's Disease
Ferreira, L. S. S., Fernandes, C., Vieira, M. N. N., & Felice, F. G. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00830 · Cited by 229 · see citing works
Hypothalamic control of energy balance: insights into the role of synaptic plasticity
Dietrich, M. O., & Horvath, T. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.005 · Cited by 227 · see citing works
The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy
Becerra-Calixto, A., & Cardona‐Gómez, G. P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00088 · Cited by 225 · see citing works
Insulin regulates astrocyte gliotransmission and modulates behavior
Cai, W., Xue, C., Sakaguchi, M., Konishi, M., Shirazian, A., Ferris, H. A., Li, M. E., Yu, R., Kleinridders, A., Pothos, E. N., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99366 · Cited by 222 · see citing works
Biophysical neurons, energy, and synapse controllability: a review
Ma, J. (2022) · Journal of Zhejiang University. Science A · doi:10.1631/jzus.a2200469 · Cited by 225 · see citing works

Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes
Shichkova, P., Coggan, J. S., Markram, H., & Keller, D. X. (2024) · Cells · doi:10.3390/cells13201714 · Cited by 37 · see citing works
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580 · see citing works
The neuron–astrocyte metabolic unit as a cornerstone of brain energy metabolism in health and disease
Bolaños, J. P., & Magistretti, P. J. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01404-9 · Cited by 45 · see citing works
Self-citation
Brain energy metabolism: Astrocytes in neurodegenerative diseases.
Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13982 · Cited by 153 · see citing works
Energy on demand
Pellerin, L. (2004) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-832864

Authors: Bélanger, M., Allaman, I., & Magistretti, P. J.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author: Magistretti, Pierre J.
ORCID: Allaman, Igor
Magistretti, Pierre J.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2011-12
Volume: 14
Issue: 6
Pages: 724-738
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2011.08.016
OpenAlex: W2016927879
Cited by: 2,313
References: 135
Citations by year: 2026: 169 · 2025: 194 · 2024: 206 · 2023: 207 · 2022: 197 · 2021: 218 · 2020: 203 · 2019: 175 · 2018: 159 · 2017: 152 · 2016: 137 · 2015: 111 · 2014: 76 · 2013: 73 · 2012: 31
FWCI: 5.48
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 630 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain energy metabolism, astrocytes, neurons, neuroenergetics, glial cells, energy storage, neuronal activity
MeSH terms: Astrocytes, Brain, Energy Metabolism, Glycogen, Models, Biological, Neurons, Regional Blood Flow, Oxidative Stress, Lactic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks