Astrocyte Ca2+ signalling: an unexpected complexity
Open accessAbstract
Astrocyte Ca(2+) signalling has been proposed to link neuronal information in different spatial-temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In parallel, new experimental approaches that enable the study of astrocyte physiology at higher spatial-temporal resolution in intact brain preparations are beginning to reveal an unexpected level of compartmentalization and sophistication in astrocytic Ca(2+) dynamics. This newly revealed complexity needs to be attentively considered in order to understand how astrocytes may contribute to brain information processing.
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Astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions, and contribute to behavior.
“astrocyte interactions with synaptic circuits are multimodal and multiscale, occur under physiological conditions 2-5 and contribute to behavior 6-8 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [5]
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- Authors
- Volterra, A., Liaudet, N., & Savtchouk, I.
- Affiliations
- University of Lausanne (CH)
- Corresponding author
- Volterra, Andrea
- Venue
- Nature Reviews Neuroscience
- Published
- 2014-04-17
- Volume
- 15
- Issue
- 5
- Pages
- 327-335
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1972077052
- Cited by
- 446
- References
- 117
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 27 · 2023: 32 · 2022: 27 · 2021: 43 · 2020: 44 · 2019: 52 · 2018: 50 · 2017: 37 · 2016: 38 · 2015: 43 · 2014: 6
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
- iris.unil.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140999, 31003A)
- FP7 Ideas: European Research Council (340368)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- astrocytes, calcium signaling, calcium dynamics, synaptic function, brain information processing, astrocyte-neuron interaction, brain integration
- MeSH terms
- Animals, Astrocytes, Brain, Calcium, Humans, Synapses, Calcium Signaling
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