Cited by 325Maternal Mental Health During Pregnancy and PostpartumNeuroendocrine regulation and behaviorInfant Health and Development

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The Neurobiology of Postpartum Anxiety and Depression

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Pawluski, Jodi L., Lonstein, Joseph S., Fleming, Alison S.·2017·Trends in Neurosciences

DOI 10.1016/j.tins.2016.11.009

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Abstract

Ten to twenty percent of postpartum women experience anxiety or depressive disorders, which can have detrimental effects on the mother, child, and family. Little is known about the neural correlates of these affective disorders when they occur in mothers, but they do have unique neural profiles during the postpartum period compared with when they occur at other times in a woman's life. Given that the neural systems affected by postpartum anxiety and depression overlap and interact with the systems involved in maternal caregiving behaviors, mother-infant interactions are highly susceptible to disruption. Thus, there is an intricate interplay among maternal mental health, the mother-infant relationship, and the neurobiological mechanisms mediating them that needs to be the focus of future study.

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Authors: Pawluski, J. L., Lonstein, J. S., & Fleming, A. S.
Affiliations: Inserm (FR)
Michigan State University (US)
University of Toronto (CA)
Corresponding author: Pawluski, Jodi L.
Lonstein, Joseph S.
ORCID: Pawluski, Jodi L.
Lonstein, Joseph S.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2017-02
Volume: 40
Issue: 2
Pages: 106-120
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2016.11.009
OpenAlex: W2581908356
Semantic Scholar: 1a04b202342821d315811b033e4fe93b525072d4
Cited by: 325
References: 189
Citations by year: 2026: 29 · 2025: 42 · 2024: 40 · 2023: 28 · 2022: 35 · 2021: 39 · 2020: 46 · 2019: 27 · 2018: 27 · 2017: 9
FWCI: 4.84
Type: journal article
Language: en
Open access: green
univ-rennes.hal.science
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Funders: Canadian Institutes of Health Research
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057962)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
Keywords: postpartum anxiety, postpartum depression, maternal mental health, mother-infant relationship, maternal care, neural correlates, neurobiology of depression, neural correlates of anxiety, mother-infant interaction
MeSH terms: Animals, Anxiety, Depression, Humans, Maternal Behavior, Mother-Child Relations, Mothers, Postpartum Period

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The Neurobiology of Postpartum Anxiety and Depression

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