ACE2: from vasopeptidase to SARS virus receptor

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9

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Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R. P., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M., et al. (2003) · Science · doi:10.1126/science.1085952 · Cited by 2,477 · see citing works

A Human Homolog of Angiotensin-converting Enzyme

Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,032 · see citing works

The Genome Sequence of the SARS-Associated Coronavirus

Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A. R., Butterfield, Y. S. N., Khattra, J. S., Asano, J. K., Barber, S., Chan, S. Y., et al. (2003) · Science · doi:10.1126/science.1085953 · Cited by 2,017 · see citing works

Angiotensin-converting enzyme 2 is an essential regulator of heart function

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Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase

Vickers, C., Hales, P., Kaushik, V. K., Dick, L. R., Gavin, J. M., Tang, J., Godbout, K., Parsons, T. F., Baronas, E., Hsieh, F., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200581200 · Cited by 1,406 · see citing works

Human aminopeptidase N is a receptor for human coronavirus 229E

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Crystal structure of the human angiotensin-converting enzyme–lisinopril complex

NATESH, R., Schwager, S. L. U., Sturrock, E. D., & Acharya, K. R. (2003) · Nature · doi:10.1038/nature01370 · Cited by 891 · see citing works

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Towler, P., Staker, B. L., Prasad, S. G., Menon, S., Tang, J., Parsons, T. F., Ryan, D., Fisher, M., Williams, D., Dales, N. A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311191200 · Cited by 699 · see citing works

A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2

Wong, S. K., Li, W., Moore, M. J., Choe, H., & Farzan, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300520200 · Cited by 690 · see citing works

Counterregulatory Actions of Angiotensin-(1-7)

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The angiotensin–converting enzyme gene family: genomics and pharmacology

Turner, A. J., & Hooper, N. M. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01994-5 · Cited by 407 · see citing works

The SARS-CoV S glycoprotein: expression and functional characterization

Xiao, X., Chakraborti, S., Dimitrov, A., Gramatikoff, K., & Dimitrov, D. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.054 · Cited by 370 · see citing works

Characterization of Renal Angiotensin-Converting Enzyme 2 in Diabetic Nephropathy

Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W. C., Burrell, L. M., Risvanis, J., & Cooper, M. E. (2003) · Hypertension · doi:10.1161/01.hyp.0000060689.38912.cb · Cited by 349 · see citing works

Ace revisited: A new target for structure-based drug design

Acharya, K. R., Sturrock, E. D., Riordan, J. F., & Ehlers, M. R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1227 · Cited by 342 · see citing works

Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus

Cavanagh, D. (2003) · Avian Pathology · doi:10.1080/03079450310001621198 · Cited by 333 · see citing works

Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles

Zisman, L. S., Keller, R. S., Weaver, B. A., Lin, Q., Speth, R. C., Bristow, M. R., & Canver, C. C. (2003) · Circulation · doi:10.1161/01.cir.0000094734.67990.99 · Cited by 308 · see citing works

Novel Peptide Inhibitors of Angiotensin-converting Enzyme 2

Huang, L., Sexton, D. J., Skogerson, K., Devlin, M., Smith, R. G., Sanyal, I., Parry, T. J., Kent, R. B., Enright, J., Wu, Q., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212934200 · Cited by 217 · see citing works

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins

Donoghue, M. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00177-9 · Cited by 214 · see citing works

A model of the ACE2 structure and function as a SARS-CoV receptor

Prabakaran, P., Xiao, X., & Dimitrov, D. S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.12.081 · Cited by 209 · see citing works

Angiotensin-Converting Enzyme-2 (ACE2): Comparative Modeling of the Active Site, Specificity Requirements, and Chloride Dependence

Guy, J. L., Jackson, R. M., Acharya, K. R., Sturrock, E. D., Hooper, N. M., & Turner, A. J. (2003) · Biochemistry · doi:10.1021/bi035268s · Cited by 191 · see citing works

Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors

Dales, N. A., Gould, A. E., Brown, J. A., Calderwood, E. F., Guan, B., Minor, C. A., Gavin, J. M., Hales, P., Kaushik, V. K., Stewart, M., et al. (2002) · Journal of the American Chemical Society · doi:10.1021/ja0277226 · Cited by 182 · see citing works

Cardiac Angiotensin-(1-7) in Ischemic Cardiomyopathy

Averill, D. B., Ishiyama, Y., Chappell, M. C., & Ferrario, C. M. (2003) · Circulation · doi:10.1161/01.cir.0000092888.63239.54 · Cited by 132 · see citing works

Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During Pregnancy

Brosnihan, K. B., Neves, L. A. A., Joyner, J., Averill, D. B., Chappell, M. C., Sarao, R., Penninger, J. M., & Ferrario, C. M. (2003) · Hypertension · doi:10.1161/01.hyp.0000085220.53285.11 · Cited by 128 · see citing works

The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication

Hiscox, J. A. (2003) · Virus Research · doi:10.1016/s0168-1702(03)00160-6 · Cited by 80 · see citing works

COVID-19 and the cardiovascular system

Zheng, Y.-Y., Ma, Y.-T., Zhang, J.-Y., & Xie, X. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0360-5 · Cited by 2,970 · see citing works

Nervous system involvement after infection with COVID-19 and other coronaviruses

Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.03.031 · Cited by 2,046 · see citing works

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2

Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J.-C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y. (2020) · Circulation Research · doi:10.1161/circresaha.120.317015 · Cited by 1,882 · see citing works

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

Verdecchia, P., Cavallini, C., Spanevello, A., & Angeli, F. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.04.037 · Cited by 1,237 · see citing works

Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure

Patel, V. B., Zhong, J.-C., Grant, M. B., & Oudit, G. Y. (2016) · Circulation Research · doi:10.1161/circresaha.116.307708 · Cited by 833 · see citing works

Interactions of coronaviruses with ACE2, angiotensin II, and RAS inhibitors—lessons from available evidence and insights into COVID-19

Kai, H., & Kai, M. (2020) · Hypertension Research · doi:10.1038/s41440-020-0455-8 · Cited by 426 · see citing works

Predictors of adverse prognosis in COVID‐19: A systematic review and meta‐analysis

Figliozzi, S., Masci, P. G., Ahmadi, N., Tondi, L., Koutli, E., Aimo, A., Stamatelopoulos, K., Dimopoulos, M., Caforio, A. L. P., & Georgiopoulos, G. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13362 · Cited by 361 · see citing works

The Angiotensin AT2 Receptor: From a Binding Site to a Novel Therapeutic Target

Steckelings, U. M., Widdop, R. E., Sturrock, E. D., Lubbe, L., Hussain, T., Kaschina, E., Unger, T., Hallberg, A., Carey, R. M., & Sumners, C. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000281 · Cited by 97 · see citing works

Renin–angiotensin system: Basic and clinical aspects—A general perspective

Vargas Vargas, R. A., Varela Millán, J. M., & Fajardo Bonilla, E. (2022) · Endocrinología, Diabetes y Nutrición (English ed.) · doi:10.1016/j.endien.2022.01.005 · Cited by 51 · see citing works

Predicting Potential SARS-COV-2 Drugs—In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking

Karki, N., Verma, N., Trozzi, F., Tao, P., Kraka, E., & Zoltowski, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041573 · Cited by 43 · see citing works

Confirmation of SARS-CoV-2 airborne dissemination indoors using “COVID-19 traps”

Orenes‐Piñero, E., Navas-Carrillo, D., Moreno‐Docón, A., Ortega-García, J. A., Torres-Cantero, A. M., García‐Vázquez, E., & Ramírez, P. (2021) · Journal of Infection · doi:10.1016/j.jinf.2021.12.017 · Cited by 4 · see citing works

Fachinformationen zu SARS-CoV-2/COVID-19

(2020) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/a-1154-3939

And now for something completely different: from 2019-nCoV and COVID-19 to 2020-nMan

Froes, F. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.02.010 · Cited by 25 · see citing works

Realizing the Potential of Anti–SARS-CoV-2 Monoclonal Antibodies for COVID-19 Management

Li, J. Z., & Gandhi, R. T. (2022) · JAMA · doi:10.1001/jama.2021.19994 · Cited by 20 · see citing works

Racing Towards the Development of Diagnostics for a Novel Coronavirus (2019-nCoV)

Lo, Y. M. D., & Chiu, R. W. K. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa038 · Cited by 26 · see citing works