Alzheimer's disease, metal ions and metal homeostatic therapy

Zatta, Paolo, Drago, Denise, Bolognin, Silvia, Sensi, Stefano L.·2009·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2009.05.002

Cited by (379)

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  71. BindingDB Entry 50009030: Development of the "hidden" multifunctional agents for Alzheimer's disease.
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  72. BindingDB Entry 50002291: Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates.
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  73. BindingDB Entry 50043092: Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
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  74. BindingDB Entry 50039257: Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.
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  75. BindingDB Entry 50045396: Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-ß-amyloid (Aß) aggregation and metal chelation properties against Alzheimer's disease.
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  76. BindingDB Entry 50000637: Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.
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  77. BindingDB Entry 50002708: Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease.
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  78. BindingDB Entry 50046853: Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease.
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  79. BindingDB Entry 50047406: Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.
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