The “toll” of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia

Cited by (438)

Items 301–400 of 438

1. Cannabinoid CB 2 Receptor Activation Attenuates Fentanyl-Induced Respiratory Depression
   Carmen A. Zavala, Ana Carla Thomaz, Vishakh Iyer, Ken Mackie, Andrea G. Hohmann · 2020 · Cannabis and Cannabinoid Research
2. Methadone Requires the Co-Activation of μ-Opioid and Toll-Like-4 Receptors to Produce Extracellular DNA Traps in Bone-Marrow-Derived Mast Cells
   Frida L. Martínez-Cuevas, Silvia Lorenia Cruz, Claudia González‐Espinosa · 2024 · International Journal of Molecular Sciences
3. Central Sensitization: Clinical Implications for Chronic Head and Neck Pain
   Arthur Roberts · 2012 · Clinical Medicine and Diagnostics
4. Interactions between glia, the immune system and pain processes during early development
   Gordon A. Barr, Deirtra A. Hunter · 2014 · Developmental Psychobiology
5. Decoding chronic pain: insights into the transition from acute to persistent pain
   Karan Wadhwa, Payal Chauhan, Govind Singh, Saurabh Kumar Jha, Abdulmajeed G. Almutary, Niraj Kumar Jha · 2025 · Open Biology
6. Maladaptive plasticity induced by morphine is mediated by hippocampal astrocytic Connexin-43
   Mahgol Darvishmolla, Negin Saeedi, Zohreh Tavassoli, Soomaayeh Heysieattalab, Mahyar Janahmadi, Narges Hosseinmardi · 2023 · Life Sciences
7. Restoring the neuroprotective capacity of glial cells under opioid addiction
   Alexis C. Spencer, Bapurao Surnar, Nagesh Kolishetti, Michal J. Toborek, Shanta Dhar · 2022 · Addiction Neuroscience
8. The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture
   Janine E. Sanchez, Shahani Noor, Melody S. Sun, Justine R Zimmerly, Andrea A Pasmay, J.J. Sanchez, Arden G. Vanderwall, Mark K. Haynes, Larry A. Sklar, P. Rodrigo Escalona et al. · 2023 · Neuroscience Letters
9. Drug Addiction
   Xiaohui Wang, Thomas A. Cochran, Mark Rowland Hutchinson, Hang Hubert Yin, Linda R. Watkins · 2014 · Springer eBooks
10. Stellenwert von Opioiden in der Therapie von primären Kopfschmerzerkrankungen
    Andreas Totzeck, Charly Gaul · 2014 · Der Schmerz
11. Chapter 47. Attention-Deficit/Hyperactivity Disorder
    Timothy E. Wilens, Tamar Arit Kaminski · 2021 · American Psychiatric Association Publishing eBooks
12. Low Dose Naltrexone In The Management Of Chronic Pain Syndrome: A Meta-Analysis Of Randomized Controlled Clinical Trials
    Naveen Chandrashekar Hegde, Archana Mishra, V Divya, Rituparna Maiti, Debasish Hota, Anand Srinivasan · 2025 · Current Pain and Headache Reports
13. Opioid System and Epithelial–Mesenchymal Transition
    Marzena Łazarczyk, Dominik S. Skiba, Michel‐Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk · 2025 · Pharmaceuticals
14. Inhibitory Effects of Mas-Related Gene C Receptor on Chronic Morphine-Induced Spinal Glial Activation in Rats
    Yunshan Zhang, Mei Wang, Qiuhua Lu, Qi Li, Mingyan Lin, Jianzhong Huang, Yanguo Hong · 2018 · Journal of Pharmacology and Experimental Therapeutics
15. Hsp90: Is There an Unknown Role in Pain Neurobiology
    João Dias-Ferreira, Fani Lourença Moreira Neto · 2019 · Heat shock proteins
16. Acute morphine blocks spinal respiratory motor plasticity via long‐latency mechanisms that require toll‐like receptor 4 signalling
    Arash Tadjalli, Yasin Baris Seven, Abhisheak Sharma, Christopher R. McCurdy, Donald C. Bolser, Erica S. Levitt, Gordon S. Mitchell · 2021 · The Journal of Physiology
17. Emerging Roles for Glial Pathology in Addiction
    Kathryn J. Reissner, Peter W. Kalivas · 2014 · Springer eBooks
18. Hyperbaric oxygen treatment attenuates naloxone-precipitated opioid withdrawal behaviors and alters microglial activity in male and female mice
    Meg T. Southard, Giuseppe Giannotti, Amit Thakar, Trinity R Willsey, Lydia G. Bailey, Frank Salazar, Shane T. Hentges, Raymond Mark Quock, Travis E. Brown · 2025 · Scientific Reports
19. Alpha-pinene attenuates neuroinflammatory responses in the rat hippocampus and improves spatial working memory deficits associated with morphine dependence and withdrawal
    Shamseddin Ahmadi, Bestan Yousif Abdullah, Shnya Dlshad Taeeb, Hawsar Rashid Ahmed, Mohammad Majidi · 2025 · Behavioural Brain Research
20. Pearls for opioid use in seriously ill patients
    Lee A. Kral, Jennifer Ku, Benjamin S. Kematick, Jeffrey Fudin · 2019 · Journal of Pain & Palliative Care Pharmacotherapy
21. Chapter 20. Neurobiology and Treatment of Sedative-, Hypnotic-, and Anxiolytic-Related Disorders
    Jennifer Lynn Jones, Amy VandenBerg, Robert J Malcolm · 2021 · American Psychiatric Association Publishing eBooks
22. Toll-Like Receptor 4 in Pain: Bridging Molecules-to-Cells-to-Systems
    Sanam Mustafa, Samuel G. Evans, Benjamin Barry, Daniel Thomas Barratt, Yibo Wang, Cong Lin, Xiaohui Wang, Mark Rowland Hutchinson · 2022 · Handbook of experimental pharmacology
23. Effect of Gene Variants on Opioid Dose, Pain and Adverse Effect Outcomes in Advanced Cancer: An Explorative Study
    Aaron Kee Yee Wong, Pål Klepstad, Andrew Alexander Somogyi, Sara Vogrin, Brian Huong Canh Le, Jennifer A. M. Philip, Justin P. Rubio · 2009 · Pharmacogenomics
24. Neuroimmunological Manifestations of Chemotherapy Exposure: Implications for Mucositis, Glia and Cognition
    Juliana Esma Bajic, Gordon Stanley Howarth, Ian N. Johnston, Mark Rowland Hutchinson · 2018 · Journal of Cancer Science and Research
25. Withdrawal-associated injury site pain prevalence and correlates among opioid-using people who inject drugs in Vancouver, Canada
    Launette Marie Rieb, Kora DeBeck, Kanna Hayashi, Evan Wood, Ekaterina Nosova, M‐J Milloy · 2020 · Drug and Alcohol Dependence
26. Chapter 10. Neurobiology of Stimulants
    Mehmet Sofuoglu, Elise E. DeVito, Thomas R. Kosten · 2021 · American Psychiatric Association Publishing eBooks
27. Chapter 14. Opioid Antagonist Treatment of Opioid-Related Disorders
    Michael Capata, Karen J. Hartwell · 2021 · American Psychiatric Association Publishing eBooks
28. Immunity and pain: is it time for the birth of immunoalgology?
    Edoardo Arcuri, Sebastiano Mercadante, Angela Santoni · 2021 · Minerva Anestesiologica
29. Chapter 34. Nicotine and Public Health
    K. Michael Cummings, Ron Borland, David C. Braak · 2021 · American Psychiatric Association Publishing eBooks
30. Investigation of the Effects of Opioids on Microglial Nitrite and Nitric Oxide Synthase (iNOS) Production and Phagocytosis during Inflammation
    Yi Zhou, Xihua Lu, Yunfei Zhang, Changsheng Li, Yu Bai, Zhen Zhang · 2022 · Combinatorial Chemistry & High Throughput Screening
31. The actions of morphine on microglia and the underlying effects on associated adverse effects
    Weihua Wu, Qian Li, Fei Yang · 2025 · Psychopharmacology
32. Opioid-Induced Constipation: Mechanistic Insights, Experimental Models, and Future Perspectives
    Yu-Jia Lin, Pan-Pan Lu, Qiang Ding, Xiang Tao, Qinghai Tan, Mei Liu · 2026 · Biomedicines
33. Chapter 4. Substance Use Disorder Diagnoses in DSM-5
    Deborah S. Hasin, Farren R. Roelofs Larson · 2021 · American Psychiatric Association Publishing eBooks
34. Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions
    Consuelo Guerri, María Pascual · 2012 · Springer eBooks
35. Muscle-Based Conditions
    Steven L. Kraus, Steven D. Bender, Janey Prodoehl · 2017 · Springer eBooks
36. Opioids
    George F. Koob, Michael A. Arends, Mandy L. McCracken, Michel Le Moal · 2023 · Elsevier eBooks
37. Sustained morphine exposure alters spinal NMDA receptor and astrocyte expression and exacerbates chronic pain behavior in female rats
    Sara Vieira Goncalves, Stephen G. Woodhams, Li Li, Gareth J. Hathway, Victoria Chapman · 2024 · PAIN Reports
38. Neuropathic pain treatment and research: experiences from the United Kingdom mission to Afghanistan and future prospects
    Paul Wood, C. Small, S Lewis, Peter F. Mahoney · 2017 · Journal of the Royal Army Medical Corps
39. Central Sensitization, Central Sensitization Syndromes, and Chronic Neuropathic Pain
    Leonard B. Kamen · 2017 · Elsevier eBooks
40. Chapter 49. Schizophrenia Spectrum and Other Psychotic Disorders
    Elizabeth Schwartz, Mary F. Brunette, Alan I. Green · 2021 · American Psychiatric Association Publishing eBooks
41. Chapter 18. Neurobiology of Nicotine and Tobacco
    Noah R. Gubner, Neal L. Benowitz · 2021 · American Psychiatric Association Publishing eBooks
42. Migraine Pathogenesis
    David W. Dodick, Stephen David Silberstein · 2016
43. Caspase inhibitors may attenuate opioid-induced hyperalgesia and tolerance via inhibiting microglial activation and neuroinflammation
    Zelin Weng, Yun Lin, Jiancheng Zhang, Shanglong Yao · 2013 · Journal of Medical Hypotheses and Ideas
44. Chapter 5. Assessment
    TIMOTHY W. FONG · 2021 · American Psychiatric Association Publishing eBooks
45. Neuroglia in substance use disorders
    Emily M. Castro, Shahrdad Lotfipour, Frances M. Leslie · 2025 · Handbook of clinical neurology
46. Adolescent morphine exposure does not alter low-dose lipopolysaccharide (LPS)-induced sickness behavior in adult C57/BL6 mice
    Natalie V. Davidson, Cynthia Masese, Caitlin Han, Lili A. Massac, Yuu Ishikawa, Grace Reynolds, Codey Smithson, Jackson Cook, Melissa T. Manners, Shivon A. Robinson · 2025 · PLoS ONE
47. BTP2, a store-operated calcium channel inhibitor, attenuates morphine antinociceptive tolerance in rats
    Weibo Xiao, Feng Xiao, Yingying Zhang, Lei Zeng · 2026 · Frontiers in Neuroscience
48. Activation of TGF-β/ALK5/SMAD signaling alleviates behavioral and neurochemical deficits in tramadol withdrawal
    Shahid Nazir Wani, Amarjot Kaur Grewal, Ojashvi Sharma, Amit Kumar, Varinder Singh, Heena Khan, Takveer Singh, Tanveer Singh, Sheikh F Ahmad, Haneen A. Al‐Mazroua · 2026 · Toxicology and Applied Pharmacology
49. Effect of glial inhibition in attenuation of neuropathic pain and improvement of morphine analgesic effect in a rat model of neuropathy
    Samad Nazemi, Homa Shardi Manaheji, Abbas Haghparast, Jalal Zaringhalam, M.D. Mustafa Sadegi · 2012
50. The effects of hydromorphone on astrocytic responses in cerebral ischemia
    Chang Hyung Lee, Young Cheol Park, Jae Hwan Kim, Woon Young Kim, Yoon Sook Lee, Yun Hee Kim, Too Jae Min · 2016 · Anesthesia and Pain Medicine
51. Understanding the Agent, Part I: Opioid Biology and Basic Pharmacology
    Heath B. McAnally · 2017 · Springer eBooks
52. The Adenosine-Receptor Axis in Chronic Pain
    Daniela Salvemini, Timothy M. Doyle, Tally M. Largent‐Milnes, Todd W. Vanderah · 2018 · Springer eBooks
53. Chapter 8. Neurobiology of Alcohol
    Markus A Heilig, Rainer Spanagel · 2021 · American Psychiatric Association Publishing eBooks
54. Chapter 36. Substance-Related Disorders in Women
    Grace Hennessy, Constance Guille, Shelly F. Greenfield · 2021 · American Psychiatric Association Publishing eBooks
55. Chapter 39. Substance Use and Related Disorders in Sexual and Gender Minority Populations
    Jeremy D. Kidd · 2021 · American Psychiatric Association Publishing eBooks
56. Chapter 11. Treatment of Stimulant-Related Disorders
    Richard A. Rawson, Kristen Schmidt, Larissa J. Mooney · 2021 · American Psychiatric Association Publishing eBooks
57. Etiopathogenesis of medication abuse headache (MOH): abuse of analgesics
    María del Valle López Martínez, Javier Pareja Román, María Dolores Jiménez Hernández, Ceferino Maestú Unturbe, Maria del Carmen Ramirez–Castillejo · 2019 · Journal of Applied Biotechnology & Bioengineering
58. Chapter 43. Epidemiology of Co-Occurring Psychiatric and Substance Use Disorders
    Jeffrey D. Schulden, Carlos Blanco · 2021 · American Psychiatric Association Publishing eBooks
59. Chapter 40. Cross-Cultural Aspects of Substance-Related and Addictive Disorders
    Nady el‐Guebaly, Hyoun Kyoung Kim · 2021 · American Psychiatric Association Publishing eBooks
60. Chapter 51. Forensic Addiction Psychiatry
    Elie G. Aoun, Jungjin Kim · 2021 · American Psychiatric Association Publishing eBooks
61. Chapter 7. Treating Addiction Like a Chronic Illness
    Jenna L. McCauley, A. Thomas McLellan · 2021 · American Psychiatric Association Publishing eBooks
62. Chapter 38. Substance-Related Disorders in Patients With Chronic Pain
    Kelly S. Barth, Allison J. Smith · 2021 · American Psychiatric Association Publishing eBooks
63. Chapter 21. Neurobiology and Treatment of Anabolic-Androgenic Steroid–Related Disorders
    Harrison Graham Pope, Gen Kanayama · 2021 · American Psychiatric Association Publishing eBooks
64. Chapter 19. Treatment of Tobacco-Related Disorders
    Jill M. Williams, Nina A. Cooperman, Vamsee Chaguturu · 2021 · American Psychiatric Association Publishing eBooks
65. Chapter 24. Contingency Management
    Maxine L. Stitzer, Mary M. Sweeney, Nancy M. Petry · 2021 · American Psychiatric Association Publishing eBooks
66. Pathophysiology of Pain
    Stephan Alexander Schug · 2020 · Springer eBooks
67. Chapter 22. Psychodynamic Psychotherapy
    Edward J. Khantzian · 2021 · American Psychiatric Association Publishing eBooks
68. Editorial Comment
    Hannah R. Wardill, Ysabella Z. A. Van Sebille, Joanne M. Bowen, Rachel J. Gibson · 2015 · Current Opinion in Supportive and Palliative Care
69. Chapter 6. Screening and Brief Intervention
    Richard Saitz · 2021 · American Psychiatric Association Publishing eBooks
70. Glia and Neuropathic Pain
    Julie L. Wieseler, Steven F. Maier, Linda R. Watkins · 2013 · Springer eBooks
71. Therapeutic Strategies to Treat Alcohol-Related Disorders Targeting Central Immune Signaling
    Yue Hui Wu, Mark Rowland Hutchinson · 2012 · Springer eBooks
72. Chronic Pain Following Spinal Cord Injury: The Role of Immunogenetics and Time of Injury Pain Treatment
    Mark Rowland Hutchinson, Janet K. Coller, Jillian Clark, Ruth Marshall, James Walter Middleton, Vicky Staikopoulos, Francesca Alvaro, Kathy Heyman · 2012
73. Investigating the association between P2X7 receptors, microglia and the actions of morphine
    Stephen J. Medhurst · 2011 · Edinburgh Research Archive (University of Edinburgh)
74. Antiallodynic effects of microglial interleukin-1β inhibition in the spinal cord
    Yu‐Xia Chu, Min Wang, Ming Yao, Xinmei Zhou, Xia-Ying Du, Xiao Wan, Zi-Fang Li, Meng-Jia Zhu, Xiao Chen · 2011 · IEEE International Conference on Systems Biology
75. Opioid antagonists may be useful in control of intractable pain in advanced disease. A case series
    Zbigniew Żylicz, Robert Twycross, Małgorzata Krajnik · 2010 · Via Medica Journals
76. Do opioid-activated endothelial cells communicate with astrocytes and microglia in the central nervous system?
    M. Lewis · 2011 · CU Scholar (University of Colorado Boulder)
77. (+)-Morphine Activates Toll-like Receptor 4 (TLR4) in Endothelial Cells
    Anireddy Reddy · 2011 · CU Scholar (University of Colorado Boulder)
78. Supraspinal And Spinal Mechanisms Of Morphine-Induced Hyperalgesia
    Caroline A. Arout · 2014 · CUNY Academic Works (City University of New York)
79. Morphine Following Peripheral Nerve Injury Potentiates the Magnitude and Duration of Subsequent Allodynia: A Role of Toll-like Receptor 4
    Greene, Lisa · 2013 · CU Scholar (University of Colorado Boulder)
80. OpioidActivationofToll-LikeReceptor4Contributesto DrugReinforcement
    Mark Rowland Hutchinson, Alexis L. Northcutt, Takato Hiranita, X. Wang, Susannah S. Lewis, Jacob Thomas, Theresa A. Kopajtic, Lisa Carole Loram, C. Sfregola, Erika L. Galer et al. · 2012
81. Temporomandibular Joint Surgery
    2023 · Journal of Oral and Maxillofacial Surgery
82. Effects of Toll-like Receptor 4 in Morphine Administration and Tolerance
    Qingli Li · 2015 · Zhongguo shengwu huaxue yu fenzi shengwu xuebao
83. Investigating the sensitivity of juvenile social exploration at detecting the affective consequences accompanying chronic neuropathic pain
    Hardik P. Patel · 2016 · CU Scholar (University of Colorado Boulder)
84. Basic Science of Spinal Receptors
    Jeffrey S. Kroin, Asokumar Buvanendran · 2012 · Elsevier eBooks
85. Design and Functional Evaluation of an Optically Active Mu Opioid Receptor: a Step towards an Optogenetic Therapy for Pain
    Philip A. Barish · 2011 · University of Florida Digital Collections (University of Florida)
86. Hyperalgesia in early postoperative period in children operated on for oncological pathology is accompanied by an increase of TOLL-like receptors (TLP-4)
    Д. В. Дмитрієв · 2016 · Pain anesthesia and intensive care
87. Sex Differences in Morphine Analgesia and the Role of Microglia in the Periaqueductal Gray of the Rat
    Hillary H. Doyle · 2022 · Digital Archive @ GSU
88. Medical Treatment of Chronic Pelvic Pain
    Wayne R. Gillett, David Jones · 2014 · Springer eBooks
89. Attenuating the Agent: Reducing Opioid “Virulence”
    Heath B. McAnally · 2017 · Springer eBooks
90. Opioid Antagonist Enhances Meditation Analgesia in Experienced Meditators
    Lisa M. May, Peter S. Kosek, Fadel Z. Zeidan, Elliot T. Berkman · 2017
91. Mechanisms of Physiologic Pain
    Siu Fung Chan, Salim Michel Hayek, Elias Veizi · 2018 · Springer eBooks
92. Sex differences in allodynia: a complex interaction between 17beta-oestradiol and the innate immune system.
    Lauren L. Nicotra · 2015 · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
93. Development of Laparotomy as an Animal Model for Post-Operative Pain Enhancement by Morphine
    Renee A. Dreher · 2019 · CU Scholar (University of Colorado Boulder)
94. Chapter 52. Medical Education on Addiction
    Jeffrey J. DeVido, Ellen Lockard Edens, Robert Werner, Elizabeth F. Howell · 2021 · American Psychiatric Association Publishing eBooks
95. Chapter 29. Digitally Delivered Therapies
    Sarah Lord, Katherine M Seavey, Alan Jeffrey Budney, Lisa A. Marsch · 2021 · American Psychiatric Association Publishing eBooks
96. Chapter 17. Treatment of Cannabis-Related Disorders
    Christina Brezing, Souparno Mitra, FRANCES RUDNICK LEVIN · 2021 · American Psychiatric Association Publishing eBooks
97. Chapter 15. Neurobiology and Treatment of Hallucinogen Use Disorder
    Elias Dakwar · 2021 · American Psychiatric Association Publishing eBooks
98. Chapter 32. Cannabis Policy and Use
    Arthur Robin Williams · 2021 · American Psychiatric Association Publishing eBooks
99. Chapter 41. Substance-Related Disorders in Older Adults
    Maria A. Sullivan · 2021 · American Psychiatric Association Publishing eBooks
100. Chapter 9. Treatment of Alcohol-Related Disorders
     Alyssa Braxton, Tara Wright, Hugh Myrick · 2021 · American Psychiatric Association Publishing eBooks