PCNA: a silent housekeeper or a potential therapeutic target?

Translating the Histone Code

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RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

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PCNA, the Maestro of the Replication Fork

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Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer

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PCNA: structure, functions and interactions

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Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

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Identity of the proliferating cell nuclear antigen and cyclin

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HP1 and the dynamics of heterochromatin maintenance

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Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

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Principles of ubiquitin and SUMO modifications in DNA repair

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Regulation of the c-Abl and Bcr–Abl tyrosine kinases

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A search for differential polypeptide synthesis throughout the cell cycle of HeLa cells.

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c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGFPreprint

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CUL4–DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

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Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture

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Regulation of PCNA–protein interactions for genome stability

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Proliferating cell nuclear antigen (PCNA): ringmaster of the genome

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Triple negative breast cancer: unmet medical needs

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Tyrosine phosphorylation controls PCNA function through protein stability

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Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

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PCNA on the crossroad of cancer

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A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

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Ubiquitin signalling in DNA replication and repair

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Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen

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Nuclear trafficking of the epidermal growth factor receptor family membrane proteins

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Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin

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Mechanism of CRL4Cdt2, a PCNA-dependent E3 ubiquitin ligasePreprint

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Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44

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Structural and Thermodynamic Analysis of Human PCNA with Peptides Derived from DNA Polymerase-δ p66 Subunit and Flap Endonuclease-1

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Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

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The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci

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Identification of a nuclear and of a cytoplasmic polypeptide whose relative proportions are sensitive to changes in the rate of cell proliferation

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Nuclear Translocation of the Epidermal Growth Factor Receptor Family Membrane Tyrosine Kinase Receptors

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Cross-talk between the proto-oncogenes Met and Ron

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A CAF‐1 dependent pool of HP1 during heterochromatin duplication

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Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival

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Cell‐cycle‐dependent regulation of DNA replication and its relevance to cancer pathology

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Identification of a novel, widespread, and functionally important PCNA-binding motif

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Regulating post-translational modifications of the eukaryotic replication clamp PCNA

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Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2 (HER2), and Epidermal Growth Factor Receptor Expression and Benefit From Lapatinib in a Randomized Trial of Paclitaxel With Lapatinib or Placebo As First-Line Treatment in HER2-Negative or Unknown Metastatic Breast Cancer

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Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer

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Reeler: new tales on an old mutant mouse

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A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker

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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

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Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells

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Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth

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A Phase I Study of Cetuximab/Paclitaxel in Patients with Advanced-Stage Breast Cancer

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Targeting Tyrosine Phosphorylation of PCNA Inhibits Prostate Cancer Growth

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Proliferating Cell Nuclear Antigen Structure and Interactions

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A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication in vivo

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The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells

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Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides

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β-Catenin is required for Ron receptor-induced mammary tumorigenesis

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Readers of PCNA modifications

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A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA

Groehler, A. L., & Lannigan, D. A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002124 · Cited by 59 · see citing works

Proliferating Cell Nuclear Antigen Complex Formation Induced by Ultraviolet Irradiation in Human Quiescent Fibroblasts as Detected by Immunostaining and Flow Cytometry

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c-Abl regulates estrogen receptor α transcription activity through its stabilization by phosphorylation

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The Ron receptor tyrosine kinase activates c-Abl to promote cell proliferation through tyrosine phosphorylation of PCNA in breast cancer

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Interaction of Proliferation Cell Nuclear Antigen (PCNA) with c-Abl in Cell Proliferation and Response to DNA Damages in Breast Cancer

Zhao, H., Ho, P.-C., Lo, Y., Espejo, A. B., Bedford, M. T., Hung, M., & Wang, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029416 · Cited by 51 · see citing works

Crystallization of Proliferating Cell Nuclear Antigen (PCNA) from Saccharomyces cerevisiae

Krishna, T. S. R., Fenyö, D., Kong, X., Gary, S. L., Chait, B. T., Burgers, P., & Kuriyan, J. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1495 · Cited by 45 · see citing works

Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2

Havens, C. G., Shobnam, N., Guarino, E., Centore, R. C., Zou, L., Kearsey, S. E., & Walter, J. C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.337683 · Cited by 45 · see citing works

The discovery of labile methyl esters on proliferating cell nuclear antigen by MS/MS

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Expression of tyrosine kinases in human malignancies as potential targets for kinase-specific inhibitors

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Enhanced Resistance to Tamoxifen by the c-ABL Proto-oncogene in Breast Cancer

Zhao, H., Ou‐Yang, F., Chen, I., et al. (2010) · Neoplasia · doi:10.1593/neo.91576 · Cited by 40 · see citing works

PCNA Protein Expression during Spermatogenesis of the Japanese Eel (Anguilla japonica)

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Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

Actis, M. L., Inoue, A., Evison, B. J., Perry, S., Punchihewa, C., & Fujii, N. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.01.022 · Cited by 40 · see citing works

A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design

Warbrick, E. (2005) · Oncogene · doi:10.1038/sj.onc.1209320 · Cited by 40 · see citing works

Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas

Bukholm, I., Bukholm, G., Holm, R., et al. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.5.368 · Cited by 39 · see citing works

A unique form of proliferating cell nuclear antigen is present in malignant breast cells.

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Changes in the nuclear distribution of cyclin (PCNA) during S‐phase are not triggered by post‐translational modifications that are expected to moderately affect its charge

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Ron receptor tyrosine kinase signaling as a therapeutic target

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Prognostic relevance of proliferating cell nuclear antigen and p53 expression in non-small cell lung cancer

Dworakowska, D., Góźdź, S. S., Jassem, E., et al. (2002) · Lung Cancer · doi:10.1016/s0169-5002(01)00287-2 · Cited by 35 · see citing works

Epidermal Growth Factor Receptor Protects Proliferating Cell Nuclear Antigen from Cullin 4A Protein-mediated Proteolysis

Lo, Y., Ho, P.-C., & Wang, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.388843 · Cited by 31 · see citing works

PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition

Komatsu, K., Wharton, W., Hang, H., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203901 · Cited by 31 · see citing works

Elevated expression of cancer‐associated proliferating cell nuclear antigen in high‐grade prostatic intraepithelial neoplasia and prostate cancer

Wang, X., Hickey, R. J., Malkas, L. H., et al. (2010) · The Prostate · doi:10.1002/pros.21291 · Cited by 30 · see citing works

Distinct pools of proliferating cell nuclear antigen associated to DNA replication sites interact with the p125 subunit of DNA polymerase δ or DNA ligase I

Riva, F., Savio, M., Cazzalini, O., Stivala, L. A., Scovassi, A. I., Cox, L. S., Ducommun, B., & Prosperi, E. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.025 · Cited by 28 · see citing works

Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation

Venturi, A., Piaz, F. D., Giovannini, C., Gramantieri, L., Chieco, P., & Bolondi, L. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.50 · Cited by 27 · see citing works

Correlation between angiogenesis, apoptosis and cell proliferation in invasive ductal carcinoma of the breast and their relation to tumor behavior.

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Conditional Deletion of β-Catenin in Mammary Epithelial Cells of Ron Receptor, Mst1r, Overexpressing Mice Alters Mammary Tumorigenesis

Wagh, P. K., Zinser, G. M., Gray, J. K., Shrestha, A., & Waltz, S. E. (2012) · Endocrinology · doi:10.1210/en.2011-1543 · Cited by 21 · see citing works

Evaluation of prognostic factors in male breast cancer

Temmim, L., Luqmani, Y. A., Jarallah, M. A., et al. (2001) · The Breast · doi:10.1054/brst.2000.0223 · Cited by 20 · see citing works

Overcoming resistance to fulvestrant (ICI182,780) by Downregulating the c‐ABL Proto‐Oncogene in breast cancer

Zhao, H., Lo, Y., Yu, L., et al. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20721 · Cited by 20 · see citing works

Breast cancer metastatic phenotype as predicted by histologic tumor markers.

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"Cullin 4 makes its mark on chromatin".

Dai, Q., & Wang, H. (2006) · Cell Division · doi:10.1186/1747-1028-1-14 · Cited by 17 · see citing works

Inhibition of c-ABL sensitizes breast cancer cells to the dual ErbB receptor tyrosine kinase inhibitor lapatinib (GW572016).

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Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet

Lo, Y., Ho, P.-C., Chen, M., Hugo, E. R., Ben‐Jonathan, N., & Wang, S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.11.047 · Cited by 15 · see citing works

Comparative Evaluation of p53-Protein Expression and the PCNA and Ki-67 Proliferating Cell Indices in Human Astrocytomas

Kordek, R., Biernat, W., Dêbiec‐Rychter, M., et al. (1996) · Pathology - Research and Practice · doi:10.1016/s0344-0338(96)80222-6 · Cited by 14 · see citing works

Correlation between proliferating cell nuclear antigen and p53 protein expression and 5-year survival rate in nasopharyngeal carcinoma

Wang, L., Chai, C., Kuo, W., et al. (2006) · American Journal of Otolaryngology · doi:10.1016/j.amjoto.2005.07.018 · Cited by 13 · see citing works

A novel biomarker for the detection of esophageal adenocarcinoma

Hammoud, Z. T., Badve, S., Saxena, R., et al. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.09.011 · Cited by 7 · see citing works

Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Choe, K. N., & Moldovan, G.-L. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.020 · Cited by 325 · see citing works

Extracellular vesicles deposit <i>PCNA</i> to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Lei, Q., Gao, F., Liu, T., Ren, W., Chen, L., Cao, Y., Chen, W., Guo, S., Zhang, Q., Chen, W., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8697 · Cited by 170 · see citing works

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

Lim, S., Khoo, R., Peh, K. M., Teo, J., Chang, S. C., Ng, S., Beilhartz, G. L., Melnyk, R. A., Johannes, C. W., Brown, C. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920251117 · Cited by 170 · see citing works

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

Villafañez, F., García, I. A., Carbajosa, S., Pansa, M. F., Mansilla, S., Llorens, M. C., Angiolini, V., Guantay, L., Jacobs, H., Madauss, K. P., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0724-7 · Cited by 30 · see citing works

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation

Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23 · see citing works

PCNA tyrosine phosphorylation by EGFR promotes genome instability

Ortega, J., Li, J., Ensor, M., et al. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.542.6

The role of mismatch repair in DNA damage-induced apoptosis.

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[DNA repair enzymes and their genes].

Krokan, H. E., & Slupphaug, G. (1998) · PubMed · Cited by 2 · see citing works

PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA

Dieckman, L. M., Freudenthal, B., & Washington, M. T. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4572-8_15 · Cited by 109 · see citing works