Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

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Causes and consequences of replication stress

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PCNA, the Maestro of the Replication Fork

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Base Excision Repair

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Understanding nucleotide excision repair and its roles in cancer and ageing

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Proliferating cell nuclear antigen (PCNA): a dancer with many partners

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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

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Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA

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Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

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Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

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Crosstalk between SUMO and Ubiquitin on PCNA Is Mediated by Recruitment of the Helicase Srs2p

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Human mutation rate associated with DNA replication timing

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Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells

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Recruitment of DNA methyltransferase I to DNA repair sites

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Principles and Concepts of DNA Replication in Bacteria, Archaea, and EukaryaPreprint

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The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

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Regulation of PCNA–protein interactions for genome stability

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PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4 Cdt2 ubiquitin ligase complexPreprint

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Defective DNA Repair and Neurodegenerative Disease

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Tyrosine phosphorylation controls PCNA function through protein stability

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PCNA connects DNA replication to epigenetic inheritance in yeast

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PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication

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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

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The Many Roles of PCNA in Eukaryotic DNA Replication

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Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress

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Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

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PCNA: a silent housekeeper or a potential therapeutic target?

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The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase

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Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

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The Elg1 replication factor C-like complex functions in PCNA unloading during DNA replication

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Ubiquitin-dependent DNA damage bypass is separable from genome replication

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Identification of six new susceptibility loci for invasive epithelial ovarian cancer

EMBRACE, Kuchenbaecker, K. B., Collaborators, G. S., Breast Cancer Family Registry, HEBON, KConFab Investigators, Australian Cancer Study (Ovarian Cancer Investigators), Australian Ovarian Cancer Study Group, the Consortium of Investigators of Modifiers of BRCA1 and BRCA2, Ramus, S. J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3185 · Cited by 250 · see citing works

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

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TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication

Petruk, S., Sedkov, Y., Johnston, D. M., Hodgson, J. W., Black, K. L., Kovermann, S. K., Beck, S., Canaani, E., Brock, H. W., & Mazo, A. (2012) · Cell · doi:10.1016/j.cell.2012.06.046 · Cited by 246 · see citing works

PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40

Edmunds, C. E., Simpson, L. J., & Sale, J. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.024 · Cited by 239 · see citing works

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

Lessel, D., Vaz, B., Halder, S., Lockhart, P. J., Marinovic‐Terzić, I., López-Mosqueda, J., Philipp, M., Sim, J. C. H., Smith, K. R., Oehler, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3103 · Cited by 234 · see citing works

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

Moldovan, G., Dejsuphong, D., Petalcorin, M. I. R., Hofmann, K., Takeda, S., Boulton, S. J., & D’Andrea, A. D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.010 · Cited by 232 · see citing works

Regulating DNA Replication in EukaryaPreprint

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RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

Vannier, J., Sandhu, S., Petalcorin, M. I. R., Wu, X., Nabi, Z., Ding, H., & Boulton, S. J. (2013) · Science · doi:10.1126/science.1241779 · Cited by 220 · see citing works

CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase

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Structural and Thermodynamic Analysis of Human PCNA with Peptides Derived from DNA Polymerase-δ p66 Subunit and Flap Endonuclease-1

Bruning, J. B., & Shamoo, Y. (2004) · Structure · doi:10.1016/j.str.2004.09.018 · Cited by 206 · see citing works

DNA damage tolerance: when it's OK to make mistakes

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Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage

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Controlling the subcellular localization of DNA polymerases ι and η via interactions with ubiquitin

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Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork

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Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

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DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

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Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

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Docking of a Specialized PIP Box onto Chromatin-Bound PCNA Creates a Degron for the Ubiquitin Ligase CRL4Cdt2

Havens, C. G., & Walter, J. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.05.012 · Cited by 178 · see citing works

SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

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Okazaki fragment maturation: nucleases take centre stage

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Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival

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DVC1 (C1orf124) is a DNA damage–targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

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Identification of a novel, widespread, and functionally important PCNA-binding motif

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New histone supply regulates replication fork speed and PCNA unloading

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CRL4Cdt2 E3 Ubiquitin Ligase Monoubiquitinates PCNA to Promote Translesion DNA Synthesis

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DNA Replication—A Matter of Fidelity

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Visualization of recombination-mediated damage bypass by template switching

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DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

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Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis

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Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response

Centore, R. C., Yazinski, S. A., Tse, A., & Zou, L. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.020 · Cited by 139 · see citing works

ATAD5 regulates the lifespan of DNA replication factories by modulating PCNA level on the chromatin

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Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication

Punchihewa, C., Inoue, A., Hishiki, A., Fujikawa, Y., Connelly, M., Evison, B., Shao, Y., Heath, R., Kuraoka, I., Rodrigues, P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.353201 · Cited by 135 · see citing works

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

Armstrong, A. A., Mohideen, F., & Lima, C. D. (2012) · Nature · doi:10.1038/nature10883 · Cited by 135 · see citing works

The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

Zlatanou, A., Despras, E., Lajus, T. B. P., Boubakour-Azzouz, I., Pouvelle, C., Stewart, G. S., Nakajima, S., Yasui, A., Ishchenko, A. A., & Kannouche, P. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.023 · Cited by 133 · see citing works

Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation

Georgescu, R. E., Schauer, G. D., Yao, N. Y., Langston, L. D., Yurieva, O., Zhang, D., Finkelstein, J., & O’Donnell, M. E. (2015) · eLife · doi:10.7554/elife.04988 · Cited by 133 · see citing works

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

Hendel, A., Krijger, P. H. L., Diamant, N., Goren, Z., Langerak, P., Kim, J., Reißner, T., Lee, K.-Y., Geacintov, N. E., Carell, T., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002262 · Cited by 132 · see citing works

Histone H3 Lysine 56 Methylation Regulates DNA Replication through Its Interaction with PCNA

Yu, Y., Song, C., Zhang, Q., DiMaggio, P. A., Garcia, B. A., York, A. G., Carey, M., & Grunstein, M. R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.019 · Cited by 127 · see citing works

The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress

Yuan, J., Ghosal, G., & Chen, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.025 · Cited by 120 · see citing works

ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress responsePreprint

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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

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Chk1 and Claspin potentiate PCNA ubiquitination

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PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA

Dieckman, L. M., Freudenthal, B., & Washington, M. T. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4572-8_15 · Cited by 109 · see citing works

A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction

Raman, M., Havens, C. G., Walter, J. C., & Harper, J. W. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.036 · Cited by 108 · see citing works

CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis

Cazzalini, O., Sommatis, S., Tillhon, M., Dutto, I., Bachi, A., Rapp, A. W., Nardò, T., Scovassi, A. I., Necchi, D., Cardoso, M. C., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku533 · Cited by 106 · see citing works

Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance

Hedglin, M., & Benkovic, S. J. (2015) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-060414-033841 · Cited by 106 · see citing works

The ADP-ribosyltransferase PARP10/ARTD10 Interacts with Proliferating Cell Nuclear Antigen (PCNA) and Is Required for DNA Damage Tolerance

Nicolae, C. M., Aho, E. R., Vlahos, A. H. S., Choe, K. N., De, S., Karras, G. I., & Moldovan, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556340 · Cited by 104 · see citing works

Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells

Müller, R., Misund, K., Holien, T., Bachke, S., Gilljam, K. M., Våtsveen, T. K., Rø, T. B., Bellacchio, E., Sundan, A., & Otterlei, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070430 · Cited by 103 · see citing works

Role of SUMO modification of human PCNA at stalled replication fork

Gali, H., Juhász, S., Mórocz, M., Hajdú, I., Fátyol, K., Szukacsov, V., Burkovics, P., & Haracska, L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks256 · Cited by 103 · see citing works

Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale

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Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth

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DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy

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CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

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