P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, Beáta, Illes, Peter·2014·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2014.08.002

Cited by (396)

Items 301–396 of 396

  1. Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R)
    Lin Qiu, Jinzhi Wang, Manju Tewari, Derek T. Rensing, Terrance M. Egan, Joel S. Perlmutter, Zhude Tu · 2024 · Bioorganic & Medicinal Chemistry
  2. Positron Emission Tomography in the Inflamed Cerebellum: Addressing Novel Targets among G Protein-Coupled Receptors and Immune Receptors
    M. Pissarek · 2020 · Pharmaceutics
  3. Analyzing the Role of the P2X7 Receptor in Epilepsy
    Mariana Alves, Laura de Diego-García, Tobías Engel · 2022 · Methods in molecular biology
  4. P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder
    Sarah Bou Sader Nehme, Sandra Sánchez‐Sarasúa, Ramy Adel, Marie Tuifua, Awatef Mohamed Ali, Amina E. Essawy, Shérine Abdel Salam, Walid Hleihel, Éric Boué‐Grabot, Marc Landry · 2024 · Frontiers in Pharmacology
  5. Experimental Study Using Multiple Strains of Prion Disease in Cattle Reveals an Inverse Relationship between Incubation Time and Misfolded Prion Accumulation, Neuroinflammation, and Autophagy
    Najiba Mammadova, M. Heather West Greenlee, S. Jo Moore, Donald S. Sakaguchi, Justin J. Greenlee · 2020 · American Journal Of Pathology
  6. The long β2,3-sheets encoded by redundant sequences play an integral role in the channel function of P2X7 receptors
    Xuefei Ma, Tingting Wang, Wenhui Wang, Li Guan, Chang-Run Guo, Xinghua Li, Yuntao Lei, Ying‐Zhe Fan, Xiaona Yang, Motoyuki Hattori et al. · 2022 · Journal of Biological Chemistry
  7. Antinociceptive effect and anti-inflammatory activity of 1,4-naphthoquinones in mice
    Sergey Kozlovskiy, Еvgeny А. Pislyagin, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Yuri E. Sabutski, Сергей Георгиевич Полоник, И. Г. Агафонова, Dmitry L. Aminin · 2024 · Exploration of neuroscience
  8. How is the P2X7 receptor signaling pathway involved in epileptogenesis?
    Caichuan Wei, Miaoying Fu, Haiju Zhang, Baozhen Yao · 2024 · Neurochemistry International
  9. Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice
    Chiara Rossi, Mariarosaria Distaso, Francesco Raggi, Claudia Kusmic, Francesco Faita, Anna Solini · 2024 · Frontiers in Nutrition
  10. Identification of rs11615992 as a novel regulatory SNP for human P2RX7 by allele-specific expression
    Tao Peng, Li Zhong, Jing Gao, Zhuan-Yi Wan, Wei-ping Fu, Chang Sun · 2019 · Zeitschrift für Induktive Abstammungs- und Vererbungslehre
  11. Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its Expression, Function and Dye Uptake Ability
    Marian Rupert, Anirban Bhattacharya, Vendula Tvrdoňová, Marie Jindřichová, Audrey Mokdad, Éric Boué‐Grabot, Hana W. Zemkova · 2020 · International Journal of Molecular Sciences
  12. BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors
    Marcus Grohmann, Michaela Schumacher, Janka Günther, Stefan M. Singheiser, Tanja Nussbaum, Florian Wildner, Zoltán Gerevich, Ronald Jabs, Daniela Hirnet, Christian Lohr et al. · 2021 · Purinergic Signalling
  13. Emerging neurobiological targets in psychiatric treatment
    Agampodi Ishan De Zoysa, Janani Govinnage, Francesco Giorlando, Seetal Dodd, JC Narayanaswamy, Michael Berk · 2026 · European Neuropsychopharmacology
  14. From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression
    Zsüliet Kristóf, Dorottya Szabó, Beáta Sperlágh, Dóra Török, Xénia Gonda · 2025 · International Journal of Molecular Sciences
  15. P2X7 receptor antagonism suppresses epileptiform‐like activity in an inflammation‐primed human iPSC‐derived neuron model of drug‐resistant epilepsy
    Jaideep Kesavan, Yitao Wang, Klaus Dinkel, Michael Hamacher, Jochen H.M. Prehn, David Clifford Henshall, Tobías Engel · 2025 · British Journal of Pharmacology
  16. Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist
    Yan Chun Xu, Xin Miao, Paulien G. M. Ravenstijn, Anja Hijzen, Mark E. Schmidt, Partha Nandy, Honghui Zhou · 2019 · Clinical and Translational Science
  17. P2X7 receptors: a bibliometric review from 2002 to 2023
    Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang · 2024 · Purinergic Signalling
  18. Astrocytic P2X7 receptor in retrosplenial cortex drives electroacupuncture analgesia
    Wei Zhao, Si-Le Liu, Si-Si Lin, Ying Zhang, Chang Chun Yu · 2024 · Purinergic Signalling
  19. Purinergic signaling in Stroke and Multiple Sclerosis: Prospects for therapies
    Abraham Cisneros-Mejorado, Antònia Colom-Casasnovas, Alberto Pérez‐Samartín, Carlos Matute · 2025 · Neuropharmacology
  20. Targeted intranasal brain delivery of brilliant blue G via mucoadhesive spanlastic nanovesicles attenuates neuroinflammation by limiting cGAS–STING signaling
    Elsayed A. Elmorsy, Sameh Saber, Norah Suliman Alsoqih, Hamad Alsaykhan, Abdulaziz A. Alsalloom, Eman Hamza, Rabab S. Hamad, Zainab H. Almansour, Mostafa M. Khodeir, Attalla Farag El-kott et al. · 2025 · Journal of Drug Delivery Science and Technology
  21. Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells
    Еvgeny А. Pislyagin, Ekaterina S. Menchinskaya, Irina N. Gladkikh, Кветкина Александра Николаевна, Oksana V. Sintsova, Daria V. Popkova, Sergey Kozlovskiy, Tatiana Y. Gorpenchenko, Лихацкая Галина Николаевна, Leonid A. Kaluzhskiy et al. · 2023 · Marine Drugs
  22. Purinergic receptor (P2X7R): A Promising Anti-Parkinson's Drug Target
    Magham Sai Varshini, L M, Praveen Thaggikuppe Krishnamurthy, Neenu Shaji, Ramakkamma Aishwarya Reddy · 2024 · Advanced Pharmaceutical Bulletin
  23. Brilliant blue G protects against brain and liver tissue damage during systemic endotoxemia in rats treated with lipopolysaccharide
    Omar M. E. Abdel‐Salam, Amany Ameen Sleem, Nadia A. Mohammed, Eman R. Youness, Noha N. Yassen, Nermeen Shaffie · 2019 · Comparative Clinical Pathology
  24. Proteomic analysis discovers potential biomarkers of early traumatic axonal injury in the brainstem
    Qianling Chen, Lingyue Li, Luyao Xu, Bin Yang, Yuebing Huang, Dongfang Qiao, Xia Yue · 2023 · International Journal of Legal Medicine
  25. Analysis of P2X7-Induced Neuronal Branching
    Paula Mut-Arbona, Beáta Sperlágh · 2022 · Methods in molecular biology
  26. Morphological Characterization of the Myenteric Plexus of the Ileum and Distal colon of Dogs Affected by Muscular Dystrophy
    Barbara Schäfer, Mariana Póvoa Silveira, Kelly Palombit, Cristina Eusébio Mendes, Ii‐Sei Watanabe, María Angélica Miglino, Patrícia Castelucci · 2017 · The Anatomical Record
  27. P2X Receptors
    Annette Nicke, Thomas Grütter, Terrance M. Egan · 2018 · Oxford University Press eBooks
  28. Purinergic signaling-induced neuroinflammation and status epilepticus
    Tobías Engel · 2016 · Expert Review of Neurotherapeutics
  29. Targeting P2X7 mitigates neurobehavioural alterations in a mouse model of post-acute sequelae of SARS-CoV-2 infection
    Dorottya Szabó, Pál Tod, Fruzsina Maácz, Flóra Gölöncsér, Bernadett Iring-Varga, Bibiána Török, Gyula Zsidei, Bernadett Pályi, Zoltán Kis, Beáta Sperlágh · 2025 · Neuropharmacology
  30. A Bibliometric Analysis of P2X7R in Cardiovascular Diseases from 2005 to 2024
    Juanjuan Tan, Wenqi Zhou, Zhiye Guo, Li Cheng, Yalong Kang, Qiong Wang, Jing Dong, Haifang Wang, Qi Zhang, Li Shen et al. · 2025 · Current Cardiology Reviews
  31. Cortical Single-Cell Primers of Abnormal Brain Activity in Parkinson’s Disease
    Daniela Mîrzac, Martin B. Glaser, Svenja L. Kreis, Florian A. Ringel, Manuel Bange, Damian Marc Herz, Stanislav A. Groppa, Lilia Rotaru, Viviane de Sousa Moreira Almeida, Jenny Blech et al. · 2025 · Research
  32. The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions
    Neha Kachappilly, Paola Pizzo, Emy Basso · 2026 · Neuropharmacology
  33. Biodistribution, radiodosimetry and pharmacokinetics of [18F]GSK1482160 for cerebral P2X7 receptor in living subjects
    Lei Bi, Kun He, Lu Wang, Peizhen Ye, Yongshan Liu, Min Yang, Junjie Wei, Jie Ma, Huiyi Wei, Weiyan Zhou et al. · 2026 · EJNMMI Research
  34. Emerging Microglial Therapies and Targets in Clinical Trial
    Ling Yan, Andrea Crotti · 2024 · Advances in neurobiology
  35. Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy
    Nelson Espinosa, Soraya Martín‐Suárez, Ariel Lara-Vásquez, Trinidad D. Montero, Teresa Muro‐García, German Fernandez, Juan Manuel Encinas, Pablo Fuentealba · 2025 · Frontiers in Neuroscience
  36. Developing Potent Therapeutics for Liver Cancer Chemoresistance via an RNA Nanotech and Series-Circuit-Christmas-Bulb Mechanism Targeting ABC Transporters
    Tesla Yudhistira, Bennett Yunker, Laksh Dhir, Yuan Soon Ho, Shujun Liu, Peixuan Guo · 2025 · Molecular Pharmaceutics
  37. Genomic Organization of Purinergic P2X Receptors
    Raúl Loera‐Valencia, Josue Jaramillo-Polanco, Andrómeda Liñán-Rico, María Guadalupe Nieto Pescador, Juan Francisco Jiménez-Bremont, Carlos Barajas‐López · 2015 · Pharmacology &amp Pharmacy
  38. Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells
    Hannah C. Leeson, Tailoi Chan‐Ling, Michael D. Lovelace, Brownlie Jeremy, Michael W. Weible, Ben J. Gu · 2019 · Journal of Visualized Experiments
  39. Inflammatory Cytokines Facilitate the Sensitivity of P2X7 Receptors Toward Extracellular ATP at Neural Progenitor Cells of the Rodent Hippocampal Subgranular Zone
    Juan Liu, Muhammad Tahir Khan, Yong Tang, Heike Franke, Péter Illés · 2018 · Neuroglia
  40. Targeting the purinergic P2X7 receptor in epilepsy: Cell types matter
    Tobías Engel, Valentina Salari, Meng-Juan Sun, Meghma Mitra · 2026 · Neuropharmacology
  41. Targeting Microglial Activation in Drug-Resistant Epilepsy: A Scoping Review of Emerging Therapeutic Strategies
    Abba Musa Abdullahi, Usama Ishaq Abdulrazak, Ibrahim Muhammad Abdullahi · 2026 · Neuroglia
  42. Neuroinflammation and Oxidative Stress in Neuropathic Pain: Mechanistic Targets for Nutraceutical-Based Interventions
    Tânia Martins, Nádia Rei, Liliana Machado-Carvalho · 2026 · Nutraceuticals
  43. Synthesis of (2S,3S)-3-Aroyl Pyroglutamic Acid Amides
    Lucia Pinčeková, Dušan Berkeš · 2020 · International Electronic Conference on Synthetic Organic Chemistry (ECSOC)
  44. Real-time Live-cell Flow Cytometry to Investigate Calcium Influx, Pore Formation, and Phagocytosis by P2X7 Receptors in Adult Neural Progenitor Cells
    Hannah C. Leeson, Tailoi Chan‐Ling, Michael D. Lovelace, Brownlie Jeremy, Michael W. Weible, Ben J. Gu · 2019 · Journal of Visualized Experiments
  45. Migraine signaling pathways: purine metabolites that regulate migraine and predispose migraineurs to headache
    Roger Gregory Biringer · 2023 · Molecular and Cellular Biochemistry
  46. Novel Antiarrhythmic and Cardioprotective Effects of Brilliant Blue G
    Omar M. E. Abdel‐Salam, Marawan A. Elbaset, Fatma A. Morsy, Amany Ameen Sleem · 2024 · MOLECULAR SCIENCES AND APPLICATIONS
  47. Possible targets in the management of various CNS disorders
    Ankur Kumar, Bhupender Nehra, Pooja A. Chawla, Viney Chawla · 2024 · Elsevier eBooks
  48. Purinergic signaling as a target for emerging neurotherapeutics
    Tobías Engel, Beáta Sperlágh · 2019 · Brain Research Bulletin
  49. Rapid Morphologic and Molecular Activation of Microglial Cells by Stimulation of the P2X7 Receptor Correlates with Neuron Loss
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Huen‐Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez, Claire H. Mitchell · 2021 · Research Square
  50. Assessment of the expression of 5-HT receptors in thehippocampus of patients with temporal lobe epilepsy with hippocampal sclerosis
    Hatun A. Alomar · 2017 · University of Birmingham Institutional Research Archive (University of Birmingham)
  51. Estudo do efeito dos antagonistas do receptor P2X7 e Panexina-1 nas células gliais entéricas no protocolo de isquemia e reperfusão intestinal.
    Cristina Eusébio Mendes · 2017
  52. P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Subjected to Mechanical Strain
    Farraj Albalawi, Wennan Lu, Jonarhan M Beckel, Jason Chu-Shern Lim, Stuart A. McCaughey, Claire H. Mitchell · 2017 · ScholarlyCommons (University of Pennsylvania)
  53. P2X7 Receptor Regulation of Hippocampal Neural Progenitor Cells
    Hannah C. Leeson · 2017 · Griffith Research Online
  54. Participação dos receptores P2X7 presentes em células da glia do gânglio da raiz dorsal na nocicepção
    Júlia Borges Paes Lemes · 2017
  55. Using RNA Interference for Purinoceptor Knockdown In Vivo
    Rebeca Padrão Amorim, Iscia Teresinha Lopes Cendes, Maria José da Silva Fernandes · 2019 · Methods in molecular biology
  56. Acute Microglial Responses to Single Non-Epileptogenic vs. Epileptogenic Seizures in Mouse Hippocampus
    Alberto Sepulveda‐Rodriguez · 2019 · DigitalGeorgetown (Georgetown University Library)
  57. Pannexin-1-Dependent Long-Term Depression at the CA3-CA1 Synapse
    Allison C. Werner · 2021
  58. Estudo dos mecanismos de ação da colite ulcerativa experimental nos neurônios entéricos em camundongos deficientes para o gene do receptor P2X7
    Henrique Inhauser Riceti Magalhães · 2022
  59. Identification of residues in the first transmembrane domain of the P2X7 that regulates receptor trafficking, sensitization, and dye uptake function
    Marian Rupert, Anirban Bhattacharya, Sonja Sivcev, Michal Knězů, Jana Cimicka, Hana W. Zemkova · 2023 · Journal of Neurochemistry
  60. Purinergic Signaling in Depression
    Deidiane Elisa Ribeiro, Manuella Pinto Kaster, Henning Ulrich, Sabrina Francesca de Souza Lisboa, Sâmia R.L. Joca · 2023 · Springer eBooks
  61. Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation
    Yong Tang, Patrizia Rubini, Haiyan Yin, Péter Illés · 2023 · Springer eBooks
  62. Purinergic Signaling in Brain Physiology
    Talita Glaser, Henning Ulrich · 2023 · Springer eBooks
  63. LncTCONS_00058568 is involved in the pathophysiologic processes mediated by P2X7R in the lower thoracic spinal cord after acute kidney injury
    Y.J. Wang, Z S Chen, Qingquan Liu, Yongman Lv · 2024 · The FASEB Journal
  64. Exploring P2x Receptor Activity: A Journey from Cellular Impact to Electrophysiological Profiling
    Anna Junker, Calvin Dunker, Laura Vinnenberg, Andreas Isaak, Elif Karabatak, Petra Hundehege, Thomas Budde, Kazuhiro Murakami · 2024 · SSRN Electronic Journal
  65. Thalamic Purinergic Receptors: A Gateway to Modulating Fibromyalgia Pain via NLRP3 Inflammasome Signaling and Pyroptosis
    Ahmed Seif El Din Kamel, Maram M. Mohamed, Hala Fahmy Zaki · 2024 · Research Square
  66. Microglial brain-derived neurotrophic factor (BDNF) supports the behavioral and synaptogenic effects of ketamine
    Samuel C. Woodburn, Alexander M. Kuhn, Kelly E Bosis, David T. Dadosky, Etienne J. Mueller, Justin L. Bollinger, Rosa Maria Salazar Gonzalez, J. Elliott Robinson, Lauren Larke Vollmer, Eric S. Wohleb · 2026 · Brain Behavior and Immunity
  67. Physiological roles and therapeutic potential of the purinergic P2X7 receptor
    Calvin Dunker, Stefan Gross, Laura Vinnenberg, Ann‐Kathrin Prinz, Oliver Koch, Anna Junker · 2025 · Elsevier eBooks
  68. Enhancing Remyelination by Blockade of Astrocytic P2X1 Receptors Signaling in Cuprizone‐Induced Demyelination Mouse Model
    Zhengtao Xu, Tianyu Gao, Hua Qiang Xie, Yuehua He, Haodong Luo, Zhenpeng Mo, Yuqian Yang, Weihong Peng, Lin Xiao · 2025 · Glia
  69. Additional file 2 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  70. Additional file 1 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  71. Additional file 1 of The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress
    Li, Xueying, Pusheng Quan, Si, Yao, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Liu, Han, Huang, Shuo, Sun, Linlin et al. · 2024 · Figshare
  72. Additional file 2 of The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress
    Li, Xueying, Pusheng Quan, Si, Yao, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Liu, Han, Huang, Shuo, Sun, Linlin et al. · 2024 · Figshare
  73. Neuroimmune Signalling: Novel Emerging Options to Treat Neurodegeneration
    Ashwani Sharma, Bhaskaranand Pancholi, Anjali Sharma, Debapriya Garabadu · 2026 · Springer eBooks
  74. Solvatochromic Study of Brilliant Blue G: Estimation of the Electric Dipole Moment in the Excited State
    Mihaela Miron, Dana Ortansa Dorohoi, Dan Gheorghe Dimitriu · 2026 · Symmetry
  75. Extracellular ATP in brain diseases
    Yitao Wang, Meghma Mitra, Tobías Engel · 2026 · Elsevier eBooks
  76. Study on the Analgesic Mechanism of Aloperine in Mice with Neuropathic Pain Based on the p38MAPK/FKN/CX3CR1 Pathway
    Ning Liu, Xiaoyun Zhu, S W Liu, Ziyi Su, Chunhao Zhu, Miaomiao Tian, Jianqiang Yu, Yue Liu · 2026 · Molecular Neurobiology
  77. In depth systemic biology analysis of central nervous system injuries
    Khalil Mallah · 2018 · theses.fr (ABES)
  78. Neurovascular unit changes after juvenile traumatic brain injury
    Aleksandra Ichkova · 2019 · theses.fr (ABES)
  79. P2X7 receptor-mediated astrocytic atrophy in the hippocampus of mice after status epilepticus
    Xuan Li, Muhammad Tahir Khan, Elek Sylvester Vizi, Beáta Sperlágh, Si-Si Lin, Alexei Verkhratsky, Patrizia Rubini, Yong Tang, Péter Illés · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  80. A functional MeCP2–LBX1 axis regulates neuronal gene expression in neuronal cells
    Shin‐ichi Horike, Makiko Meguro‐Horike · 2026 · Biochemical and Biophysical Research Communications
  81. P2X7 as Common Therapeutic Target in Brain Diseases
    T. Engel, Annette Nicke, J. Deussing, Beáta Sperlágh, Miguel Dı́az-Hernández · 2021 · MPG.PuRe (Max Planck Society)
  82. Cognitive Dysfunction and Suicide
    Franklin Sunzeri · 2026 · Springer eBooks
  83. Kv1.3 Channel Blockade by Dalfampridine Attenuates NLRP3 Inflammasome‐Driven Demyelination via the NEK7/Ripk1/FADD Pathway, Matching the Efficacy of Broad P2X7 Antagonism by Suramin in EAE
    Ahmed Seif El Din Kamel, Heba Nasr Shalaby, Yasmin A M El-Said, Dalia A. Nawwar · 2026 · Drug Development Research
  84. An-Gong-Niu-Huang-Wan ameliorates neurovascular uncoupling and facilitates recovery after cerebral ischemic stroke by mediating P2X7 receptor inhibition
    Xiao Zhang, Hongze Zhou, Jiamin Pei, Renhao Xu, Luping Xue, Y Zhang, Peiyun Qi, Xiangjian Zhang, Lijie Fu, Cong Zhang et al. · 2026 · Phytomedicine
  85. Vitamin D alleviates intracerebral hemorrhage symptoms by modulating pro-inflammatory/anti-inflammatory phenotypic transformation of microglia through P2X7R activation of NLRP3
    Xiujun Zhang, Bensi Zhang, Chun Shi, Natnicha Kampan, Waleephan Treebupachatsakul, Rungusa Pantan, Suteera Narakornsak, Manussabhorn Phatsara · 2026 · IBRO Neuroscience Reports
  86. Spatial and temporal changes in [3H]JNJ-64413739 binding to purinergic P2X7 receptor (P2X7R) after status epilepticus induced by intracerebral kainic acid in the rat
    Kristin H. Magnusdottir, Burcu Azak Pazarlar, Cansu Bilister Eğilmez, Jens Damsgaard Mikkelsen · 2026 · Journal of Neuroimmunology
  87. The P2X7R-NLRP3 inflammasome axis in Alzheimer’s disease and therapeutic potential of synthetic and plant-derived natural compounds: A review
    Rishabh Goswami, Nidhi Sharma, Vikas Jhawat, Rahul Singh, Poonam Ruhal, Dinesh Kumar Dhull · 2026 · Asian Pacific Journal of Tropical Biomedicine
  88. P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue
    Ana Fernandez Martin, Beatriz Gil, Meghma Mitra, Jaideep Kesavan, Austin Lacey, Meng-Juan Sun, Anne Marie O'Callaghan, Vincent Healy, Norman Delanty, Alan Beausang et al. · 2026 · Research Square
  89. BindingDB Entry 50046870: Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.
    BindingDB · 2017 · UC San Diego
  90. BindingDB Entry 50009606: Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.
    BindingDB · 2021 · UC San Diego
  91. BindingDB Entry 50015495: Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
    BindingDB · 2023 · UC San Diego
  92. BindingDB Entry 50007514: Synthesis and in vitro biological evaluation of new P2X7R radioligands [
    BindingDB · 2021 · UC San Diego
  93. BindingDB Entry 50022798: Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R).
    BindingDB · 2026 · UC San Diego
  94. BindingDB Entry 50000395: Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X
    BindingDB · 2019 · UC San Diego
  95. BindingDB Entry 50020135: From lead to clinic: A review of the structural design of P2X7R antagonists.
    BindingDB · 2024 · UC San Diego
  96. BindingDB Entry 50016195: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease.
    BindingDB · 2023 · UC San Diego