P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, Beáta, Illes, Peter·2014·Trends in Pharmacological Sciences
DOI 10.1016/j.tips.2014.08.002

Cited by (396)

Items 101–200 of 396

  1. A Short Guide to Electrophysiology and Ion Channels
    Hussein N. Rubaiy · 2017 · Journal of Pharmacy & Pharmaceutical Sciences
  2. P2X receptors and acupuncture analgesia
    Yong Tang, Haiyan Yin, Juan Liu, Patrizia Rubini, Péter Illés · 2018 · Brain Research Bulletin
  3. Astrocytic rather than neuronal P2X7 receptors modulate the function of the tri-synaptic network in the rodent hippocampus
    Muhammad Tahir Khan, Jan M. Deussing, Yong Tang, Péter Illés · 2018 · Brain Research Bulletin
  4. The role of P2X7 receptors in a rodent PCP-induced schizophrenia model
    Koványi, Bence, Csölle, Cecilia, Calovi, Stefano, Hanuska, Adrienn, Kató, Erzsébet, Köles, László, Bhattacharya, Anindya, Haller, József, Sperlágh, Beáta · 2016 · Scientific Reports
  5. Astroglial and Microglial Purinergic P2X7 Receptor as a Major Contributor to Neuroinflammation during the Course of Multiple Sclerosis
    Marta Sidoryk‐Wȩgrzynowicz, Lidia Strużyńska · 2021 · International Journal of Molecular Sciences
  6. P2X7 Receptors Drive Spine Synapse Plasticity in the Learned Helplessness Model of Depression
    Lilla Otrokocsi, Ágnes Kittel, Beáta Sperlágh · 2017 · The International Journal of Neuropsychopharmacology
  7. P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells
    Anna Wilkaniec, Magdalena Cieślik, Emilia Murawska, Lidia Babiec, Magdalena Gąssowska-Dobrowolska, Ewelina Pałasz, Henryk M. Jęśko, Agata Adamczyk · 2020 · International Journal of Molecular Sciences
  8. The microRNA-211-5p/P2RX7/ERK/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress
    Xueying Li, Pusheng Quan, Yao Si, Fei Liu, Yuwei Fan, Feifan Ding, Lina Sun, Han Liu, Shuo Huang, Linlin Sun et al. · 2024 · Journal of Neuroinflammation
  9. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy
    Kévin Carvalho, Elodie Martin, Aurélia Cès, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Émilie Faivre et al. · 2021 · Progress in Neurobiology
  10. Regulation of adult neural progenitor cell functions by purinergic signaling
    Yong Tang, Péter Illés · 2016 · Glia
  11. Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes
    Frances M. Muñoz, Priya A. Patel, Xinghua Gao, Yixiao Mei, Jingsheng Xia, Sofia Gilels, Huijuan Hu · 2020 · Purinergic Signalling
  12. The P2X7 receptor: a new therapeutic target in Alzheimer’s disease
    Péter Illés, Patrizia Rubini, Lumei Huang, Yong Tang · 2019 · Expert Opinion on Therapeutic Targets
  13. Untitled work
    Gürsel · 2018 · 10.1016/j.neubiorev.2018.02.005
  14. Adult mesenchymal stem cells: is there a role for purine receptors in their osteogenic differentiation?
    Marzia Carluccio, Sihana Ziberi, Mariachiara Zuccarini, Patricia Giuliani, Francesco Caciagli, Patrizia Di Iorio, Renata Ciccarelli · 2020 · Purinergic Signalling
  15. Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice
    Natalia Rodriguez-Alvarez, Eva Maria Jimenez-Mateos, Tobías Engel, Seán Quinlan, Cristina Ruedell Reschke, Ronán Michael Conroy, Anindya Bhattacharya, Geraldine B. Boylan, David Clifford Henshall · 2017 · Neuropharmacology
  16. Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders
    Alexia Duveau, Éléonore Bertin, Éric Boué‐Grabot · 2020 · Neuroscience Bulletin
  17. Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation
    Ribeiro, Deidiane E, Müller, Heidi K, Elfving, Betina, Eskelund, Amanda, Joca, Samia RL, Wegener, Gregers · 2019 · Journal of Psychopharmacology
  18. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway
    Dorottya Szabó, Pál Tod, Flóra Gölöncsér, Viktor Román, Balázs Lendvai, Lilla Otrokocsi, Beáta Sperlágh · 2022 · Brain Behavior and Immunity
  19. P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus
    David Clifford Henshall, Tobías Engel · 2015 · Epilepsy & Behavior
  20. Purinergic signaling as a basis of acupuncture-induced analgesia
    Jinrong He, Shuguang Yu, Yong Tang, Péter Illés · 2020 · Purinergic Signalling
  21. Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis
    Marcos Vinicius da Silva, Aline Rosa Marosti, Cristina Eusébio Mendes, Kelly Palombit, Patrícia Castelucci · 2017 · Acta Histochemica
  22. Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries
    Tomasz Grygorowicz, Beata Dąbrowska‐Bouta, Lidia Strużyńska · 2018 · Purinergic Signalling
  23. Salidroside Ameliorates Diabetic Neuropathic Pain in Rats by Inhibiting Neuroinflammation
    Gui-Lian Ni, Rong Chao Cui, Ai-Min Shao, Zhong‐Min Wu · 2017 · Journal of Molecular Neuroscience
  24. The Role of Nucleotides and Purinergic Signaling in Apoptotic Cell Clearance – Implications for Chronic Inflammatory Diseases
    Jin Chen, Yi Zhao, Yi Liu · 2014 · Frontiers in Immunology
  25. Pilocarpine-Induced Status Epilepticus Increases the Sensitivity of P2X7 and P2Y1 Receptors to Nucleotides at Neural Progenitor Cells of the Juvenile Rodent Hippocampus
    Katalin Rozmer, Po Gao, Michelle Gasparetti Leão Araújo, Muhammad Tahir Khan, Juan Liu, Weifang Rong, Yong Tang, Heike Franke, Ute Krügel, Maria José da Silva Fernandes et al. · 2016 · Cerebral Cortex
  26. The neuroinflammatory astrocytic P2X7 receptor: Alzheimer’s disease, ischemic brain injury, and epileptic state
    Young Ha Ahn, Yong Tang, Péter Illés · 2023 · Expert Opinion on Therapeutic Targets
  27. The Metabotropic Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy
    Mariana Alves, Edward H. Beamer, Tobías Engel · 2018 · Frontiers in Pharmacology
  28. P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
    Paola Fabbrizio, Savina Apolloni, Andrea Bianchi, Illari Salvatori, Cristiana Valle, Chiara Lanzuolo, Caterina Bendotti, Giovanni Nardo, Cinzia Volonté · 2019 · Brain Pathology
  29. Neuroinflammation in CNS diseases: Molecular mechanisms and the therapeutic potential of plant derived bioactive molecules
    Menizibeya Osain Welcome · 2020 · PharmaNutrition
  30. Role of P2×7 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes
    Wenkai Li, Guizhen Li, Yingchi Zhang, Sheng Wei, Mingyu Song, Wei Wang, Xuefeng Yuan, Hua Kang Wu, Yong Yang · 2015 · Experimental Cell Research
  31. HDAC3 Inhibitor RGFP966 Ameliorated Neuroinflammation in the Cuprizone-Induced Demyelinating Mouse Model and LPS-Stimulated BV2 Cells by Downregulating the P2X7R/STAT3/NF-κB65/NLRP3 Activation
    Wei Sun, Ning Zhang, Bingyi Liu, Junrong Yang, Gabriele Loers, Hans‐Christian Siebert, Min Wen, Xuexing Zheng, Zhengping Wang, Jun Han et al. · 2022 · ACS Chemical Neuroscience
  32. P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis
    Hannah C. Leeson, Maria A. Kasherman, Tailoi Chan‐Ling, Michael D. Lovelace, Brownlie Jeremy, Kelly M. Toppinen, Ben J. Gu, Michael W. Weible · 2018 · Stem Cells
  33. P2 receptor interaction and signalling cascades in neuroprotection
    M. Teresa Miras‐Portugal, Ma José Queipo, Juan Carlos Gil‐Redondo, Felipe Ortega, Rosa Gómez‐Villafuertes, Javier Gualix, Esmerilda G. Delicado, Raquel Pérez‐Sen · 2018 · Brain Research Bulletin
  34. P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
    Juan Mauricio Garré, Hernandez Moura Silva, Juan J. Lafaille, Guang Yang · 2020 · Nature Communications
  35. Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
    Edward H. Beamer, James J. Morgan, Mariana Alves, Aida Menéndez Méndez, Gareth Morris, Béla Zimmer, Giorgia Conte, Laura de Diego-García, Cristina Alarcón‐Vila, Nico Ka Yiu Ng et al. · 2021 · British Journal of Pharmacology
  36. High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus
    Ya-Fei Zhao, Wen-Jing Ren, Ying Zhang, Jinrong He, Haiyan Yin, Yang Liao, Patrizia Rubini, Jan M. Deussing, Alexei Verkhratsky, Zengqiang Yuan et al. · 2022 · International Journal of Molecular Sciences
  37. Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data
    Si Yuan Dai, Jingjing Lin, Yanting Hou, Xuerong Luo, Yidong Shen, Jianjun Ou · 2023 · Frontiers in Molecular Neuroscience
  38. Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity
    John F. Bowyer, Joseph P. Hanig · 2014 · Temperature
  39. Neuroimmune crosstalk and evolving pharmacotherapies in neurodegenerative diseases
    Falguni Baidya, Mariya Bohra, Aishika Datta, Deepaneeta Sarmah, Birva Shah, Priya Jagtap, Swapnil Raut, Ankan Sarkar, Upasna Singh, Kiran Kalia et al. · 2020 · Immunology
  40. Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways
    Chengli Liu, Qi Tian, Jianfeng Wang, Peibang He, Shoumeng Han, Yujia Guo, Yang Chen, Guijun Wang, Heng Li Wei, Mingchang Li · 2022 · Molecular Neurobiology
  41. Purinergic receptors in cognitive disturbances
    Péter Illés, Henning Ulrich, Jiang‐Fan Chen, Yong Tang · 2023 · Neurobiology of Disease
  42. Perinatal Brain Injury and Inflammation: Lessons from Experimental Murine Models
    A. Leavy, E. Jimenez-Mateos · 2020 · Cells
  43. Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice
    Mariana Alves, Beatriz Gil, Javier Villegas-Salmerón, Valentina Salari, Ricardo Martins-Ferreira, Marina Arribas Blázquez, Aida Menéndez Méndez, Rogério R. Gerbatin, Jonathon Smith, Laura de Diego-García et al. · 2024 · Brain Behavior and Immunity
  44. Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
    Eunshil Lee, Yongmin Chang · 2025 · Cells
  45. The role of microglia and P2X7 receptors in gliomas
    Liyen Katrina Kan, David J. Williams, Kate J Drummond, Terence John O'Brien, Mastura Monif · 2019 · Journal of Neuroimmunology
  46. Contribution of non-selective membrane channels and receptors in epilepsy
    Claudia García‐Rodríguez, Iván Darío Bravo Tobar, Yorley Duarte, Luis Carlos Barrio, Juan Carlos Sáez · 2021 · Pharmacology & Therapeutics
  47. A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22
    Tobías Engel, Gary P. Brennan, Amaya Sanz‐Rodriguez, Mariana Alves, Edward H. Beamer, Orla Watters, David Clifford Henshall, Eva Maria Jimenez-Mateos · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  48. Purinergic signaling: Diverse effects and therapeutic potential in cancer
    Jasmeet Kaur, Sanchit Dora · 2023 · Frontiers in Oncology
  49. Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPS-stimulated BV2 cells
    Chang-Min Lee, Dae-Sung Lee, Won‐Kyo Jung, Jong Su Yoo, Mi‐Jin Yim, Yung Hyun Choi, Sae-Gwang Park, Su‐Kil Seo, Jung Sik Choi, Young‐Min Lee et al. · 2016 · International Journal of Molecular Medicine
  50. Targeting Neuroinflammation via Purinergic P2 Receptors for Disease Modification in Drug-Refractory Epilepsy
    Tobías Engel, Jonathon Smith, Mariana Alves · 2021 · Journal of Inflammation Research
  51. A Molecular Model for Lithium’s Bioactive Form
    Katharine T. Briggs, Gary G. Giulian, Gong Li, Joseph P. Y. Kao, John P. Marino · 2016 · Biophysical Journal
  52. Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus
    Kelly Palombit, Cristina Eusébio Mendes, Wothan Tavares-de-Lima, Maria Luiza Morais Barreto‐Chaves, Patrícia Castelucci · 2019 · Digestive Diseases and Sciences
  53. Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components
    Miaomiao Tian, Yuxiang Li, Shan Liu, Chunhao Zhu, Xiaobing Lan, Juan Du, Lin Ma, Jiamei Yang, Ping Zheng, Jianqiang Yu et al. · 2021 · Molecules
  54. Purinergic neurone-glia signalling in cognitive-related pathologies
    Péter Illés, Alexei Verkhratsky · 2015 · Neuropharmacology
  55. Expression level of P2X7 receptor is a determinant of ATP-induced death of mouse cultured neurons
    Akihiro Ohishi, Y. Keno, A. Marumiya, Y. Sudo, Youichi Uda, K. Matsuda, Y. Morita, T. Furuta, Kentaro Nishida, Kazuki Nagasawa · 2016 · Neuroscience
  56. Tackling Chronic Pain and Inflammation through the Purinergic System
    Giulia Magni, Daniele Riccio, Stefania Ceruti · 2018 · Current Medicinal Chemistry
  57. Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders
    Lumei Huang, Lilla Otrokocsi, Beáta Sperlágh · 2019 · Brain Research Bulletin
  58. Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor
    M. Teresa Miras‐Portugal, Juan Ignacio Díaz‐Hernandéz, Rosa Gómez‐Villafuertes, Miguel Dı́az-Hernández, Antonio R. Artalejo, Javier Gualix · 2015 · Computational and Structural Biotechnology Journal
  59. MicroRNAs Modulate the Purinergic Signaling Network
    Davide Ferrari, Nicoletta Bianchi, Holger K. Eltzschig, Roberto Gambari · 2016 · Trends in Molecular Medicine
  60. Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
    Rasha Abd Ali Al-khalidi, Chiara Panicucci, Paul A. Cox, Natalia Chira, Justyna Róg, Chris Young, Rhiannon E. McGeehan, Kameshwari Ambati, Jayakrishna Ambati, Krzysztof Zabłocki et al. · 2018 · Acta Neuropathologica Communications
  61. Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges
    Dilyara Nurkhametova, Igor Vladimirovich Kudryavtsev, В. В. Гусельникова, М. К. Серебрякова, Raisa Giniatullina, Sara Wojciechowski, Fatma Töre, Albert Anatolyevich Rizvanov, Jari Koıstınaho, Tarja Malm et al. · 2019 · Frontiers in Cellular Neuroscience
  62. Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders
    Xiaoming Liu, Yiwen Li, Liting Huang, Yingyan Kuang, Xiaoxiong Wu, Xiangqiong Ma, Beibei Zhao, Jiao Lan · 2024 · Frontiers in Pharmacology
  63. Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists
    Emily A. Caseley, Stephen P. Muench, Colin W. G. Fishwick, Lin‐Hua Jiang · 2016 · Biochemical Pharmacology
  64. Purinergic Receptors in Basal Ganglia Diseases: Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease
    Talita Glaser, Roberta Andrejew, Ágatha Oliveira‐Giacomelli, Deidiane Elisa Ribeiro, Lucas Bonfim Marques, Qing Ye, Wenjing Ren, Alexey V. Semyanov, Péter Illés, Yong Tang et al. · 2020 · Neuroscience Bulletin
  65. Naofucong Ameliorates High Glucose Induced Hippocampal Neuron Injury Through Suppressing P2X7/NLRP1/Caspase-1 Pathway
    Guangchan Jing, Huanyuan Wang, Fengwei Nan, Yuqin Liu, Mengren Zhang · 2021 · Frontiers in Pharmacology
  66. PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus
    Xingfeng Liu, Zhuo Xie, Site Li, Jingxin He, Song Cao, Zhi Xiao · 2021 · International Journal of Biological Sciences
  67. Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor
    Henrique Inhauser Riceti Magalhães, Patrícia Castelucci · 2021 · World Journal of Gastroenterology
  68. P2X7 receptor signaling during adult hippocampal neurogenesis
    Ben J. Gu, Michael W. Weible, Hannah C. Leeson, Tailoi Chan‐Ling, Michael D. Lovelace, JeremyC Brownlie · 2019 · Neural Regeneration Research
  69. The role and therapeutic potential of connexins, pannexins and their channels in Parkinson's disease
    Elham Ahmadian, Aziz Eftekhari, Mohammad Samiei, Solmaz Maleki Dizaj, Mathieu Vinken · 2019 · Cellular Signalling
  70. Roles of purinergic P2X 7 receptor in glioma and microglia in brain tumors
    James G. McLarnon · 2017 · Cancer Letters
  71. Microglial ion channels: Key players in non-cell autonomous neurodegeneration
    Souvarish Sarkar · 2022 · Neurobiology of Disease
  72. Evaluation of the Anticonvulsant Effect of Brilliant Blue G, a Selective P2X7 Receptor Antagonist, in the iv PTZ-, Maximal Electroshock-, and 6 Hz-Induced Seizure Tests in Mice
    Dorota Nieoczym, Katarzyna Socała, Piotr Właź · 2017 · Neurochemical Research
  73. Understanding the Role of Dysfunctional and Healthy Mitochondria in Stroke Pathology and Its Treatment
    Hung Nguyen, Sydney Zarriello, Mira Rajani, Julian P. Tuazon, Eleonora Napoli, Cesar V. Borlongan · 2018 · International Journal of Molecular Sciences
  74. Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis
    Tomasz Grygorowicz, Lidia Strużyńska · 2018 · Inflammopharmacology
  75. Açaí (Euterpe oleracea Mart.) as a Potential Anti-neuroinflammatory Agent: NLRP3 Priming and Activating Signal Pathway Modulation
    Francine Carla Cadoná, Diulie Valente de Souza, Tuyla Fontana, David Frederick Bodenstein, Andiara Prates Ramos, Michele Rorato Sagrillo, Mirian Mendonça Salvador, Kennya Marcia dos Santos Mota, Carolina Bordin Davidson, Euler Esteves Ribeiro et al. · 2021 · Molecular Neurobiology
  76. Towards a Novel Class of Multitarget-Directed Ligands: Dual P2X7–NMDA Receptor Antagonists
    Olga Karoutzou, Seung‐Hwa Kwak, So‐Deok Lee, Daina Martínez‐Falguera, Francesc Xavier Sureda, Santiago Vázquez, Yong‐Chul Kim, Marta Barniol‐Xicota · 2018 · Molecules
  77. Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor
    Beatriz Gil, Jonathon Smith, Yong Tang, Péter Illés, Tobías Engel · 2022 · International Journal of Molecular Sciences
  78. Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease
    Bengisu Turgutalp, Prabesh Bhattarai, Tuğba Erçeti̇n, Chiara Luise, Rengin Reis, Enise Ece Gürdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Si̇pahi̇ et al. · 2022 · Journal of Medicinal Chemistry
  79. From lead to clinic: A review of the structural design of P2X7R antagonists
    Ruijia Zhang, Na Li, Min Zhao, Minghai Tang, Xueqin Jiang, Xiaoying Cai, Neng Ye, Kaiyue Su, Jing Peng, Xinlu Zhang et al. · 2023 · European Journal of Medicinal Chemistry
  80. Purinergic Antagonism Prevents Mitochondrial Dysfunction and Behavioral Deficits Associated with Dopaminergic Toxicity Induced by 6-OHDA in Rats
    Saket Kumar, Akanksha Mishra, Sairam Krishnamurthy · 2017 · Neurochemical Research
  81. The Role of NMDA Receptors in the Effect of Purinergic P2X7 Receptor on Spontaneous Seizure Activity in WAG/Rij Rats With Genetic Absence Epilepsy
    Elif Doǧan, Hatice Aygün, Gökhan Arslan, Emil Rzayev, Bahattin Avcı, Mustafa Ayyıldız, Erdal Ağar · 2020 · Frontiers in Neuroscience
  82. Regulation of Hippocampal 5-HT Release by P2X7 Receptors in Response to Optogenetic Stimulation of Median Raphe Terminals of Mice
    Gölöncsér, Flóra, Baranyi, Mária, Balázsfi, Diána, Demeter, Kornél, Haller, József, Freund, Tamás F. F., Zelena, Dóra, Sperlágh, Beáta · 2017 · Frontiers in Molecular Neuroscience
  83. Advancements in Single-Cell RNA Sequencing and Spatial Transcriptomics for Central Nervous System Disease
    Yuan Zhang, Teng Li, Guangtian Wang, Yabin Ma · 2024 · Cellular and Molecular Neurobiology
  84. Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function
    Fernando Aprile-Garcia, Michael W. Metzger, Marcelo Páez-Pereda, Herbert Stadler, Matías Acuña, Ana C. Liberman, Sergio A. Senin, Juan Gerez, Esteban Hoijman, Damián Refojo et al. · 2016 · PLoS ONE
  85. Hypoxia‐inducible factor 1 alpha (HIF‐1α) stimulated and P2X7 receptor activated by COVID-19, as a potential therapeutic target and risk factor for epilepsy
    Hamidreza Zalpoor, Abdullatif Akbari, Mohsen Nabi‐Afjadi, Razieh Forghaniesfidvajani, Chanour Tavakol, Zohreh Barzegar, Farideh Iravanpour, Mahshid Hosseini, Seyed Reza Mousavi, Majid Reza Farrokhi · 2022 · Human Cell
  86. Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells
    Sergey Kozlovskiy, Еvgeny А. Pislyagin, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Yuri E. Sabutski, Сергей Георгиевич Полоник, Лихацкая Галина Николаевна, Dmitry L. Aminin · 2023 · Toxins
  87. Under stressful conditions activation of the ionotropic P2X7 receptor differentially regulates GABA and glutamate release from nerve terminals of the rat cerebral cortex
    Barros-Barbosa, Aurora R., Oliveira, Ângela, Lobo, M. Graça, Cordeiro, J. Miguel, Correia-de-Sá, Paulo · 2018 · Neurochemistry International
  88. Plant natural products as source of new P2 receptors ligands
    Paulo Anastacio Furtado Pacheco, Roberta Tosta Diogo, Betina Quintanilha Magalhães, Robson Xavier Faria · 2020 · Fitoterapia
  89. P2x7 receptors control demyelination and inflammation in the cuprizone model
    Ana Bernal‐Chico, Andrea Manterola, Raffaela Cipriani, István Katona, Carlos Matute, Susana Mato · 2020 · Brain Behavior & Immunity - Health
  90. Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139
    Allen T. Hopper, Martin Juhl, Jorrit J. Hornberg, Lassina Badolo, John Paul Kilburn, Annemette Thougaard, Gennady N. Smagin, Dekun Song, Londye Calice, Veena Menon et al. · 2021 · Journal of Medicinal Chemistry
  91. Ca2+ flux through splice variants of the ATP-gated ionotropic receptor P2X7 is regulated by its cytoplasmic N terminus
    Xin Liang, Damien S. K. Samways, Jane A. Cox, Terrance M. Egan · 2019 · Journal of Biological Chemistry
  92. P2X7 receptor activation downmodulates Na+-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes
    Barros-Barbosa, A.R., Lobo, M.G., Ferreirinha, F., Correia-de-Sá, P., Cordeiro, J.M. · 2015 · Neuroscience
  93. Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells
    Еvgeny А. Pislyagin, Sergey Kozlovskiy, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Лихацкая Галина Николаевна, Tatiana Y. Gorpenchenko, Yuri E. Sabutski, Сергей Георгиевич Полоник, Dmitry L. Aminin · 2020 · Bioorganic & Medicinal Chemistry
  94. New Inhibitory Effects of Cilnidipine on Microglial P2X7 Receptors and IL-1β Release: An Involvement in its Alleviating Effect on Neuropathic Pain
    Tomohiro Yamashita, Sawako Kamikaseda, Aya Tanaka, Hidetoshi Tozaki‐Saitoh, José M. M. Caaveiro, Kazuhide Inoue, Makoto Tsuda · 2021 · Cells
  95. Mesial Temporal Lobe Epilepsy (MTLE) Drug-Refractoriness Is Associated With P2X7 Receptors Overexpression in the Human Hippocampus and Temporal Neocortex and May Be Predicted by Low Circulating Levels of miR-22
    Bárbara Leal, Aurora Barros‐Barbosa, Fátima Ferreirinha, João Chaves, Rui Rangel, Agostinho Santos, Cláudia Carvalho, Ricardo Martins-Ferreira, Raquel Samões, Joel Freitas et al. · 2022 · Frontiers in Cellular Neuroscience
  96. Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists
    Michael K. Ameriks, Hong Ao, Nicholas I. Carruthers, Brian Lord, Suchitra Ravula, Jason C. Rech, Brad M. Savall, Jessica L. Wall, Qi Wang, Anindya Bhattacharya et al. · 2015 · Bioorganic & Medicinal Chemistry Letters
  97. Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
    Haidong Wang, Pengfei Xu, Dehua Liao, Ruili Dang, Xin He, Yujin Guo, Pei Jiang · 2017 · BioMed Research International
  98. Increased uptake of the P2X7 receptor radiotracer 18F‐JNJ ‐64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice
    James Morgan, Óscar Moreno, Mariana Alves, Zuriñe Baz, Aida Menéndez Méndez, Hanna Leister, Ciara Melia, Jonathon Smith, Alexander Visekruna, Annette Nicke et al. · 2022 · Epilepsia
  99. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer’s Disease
    Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Dieli · 2023 · International Journal of Molecular Sciences
  100. P2X7 Receptor: an Emerging Target in Alzheimer’s Disease
    Qiang Huang, Jun Ying, Wen Yu, Yao Dong, Hao Xiong, Yiping Zhang, Jie Liu, Xifeng Wang, Fuzhou Hua · 2023 · Molecular Neurobiology