The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Nicotinic ACh receptors as therapeutic targets in CNS disorders
Open accessAbstract
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the cys-loop cation-conducting ligand-gated nicotinic ACh receptor channels (nAChRs). These receptors are widely distributed throughout the central nervous system, being expressed on neurons and non-neuronal cells, where they participate in a variety of physiological responses such as anxiety, the central processing of pain, food intake, nicotine seeking behavior, and cognitive functions. In the mammalian brain, nine different subunits have been found thus far, which assemble into pentameric complexes with much subunit diversity; however the α7 and α4β2 subtypes predominate in the CNS. Neuronal nAChR dysfunction is involved in the pathophysiology of many neurological disorders. Here we will briefly discuss the functional makeup and expression of the nAChRs in the mammalian brain, and their role as targets in neurodegenerative diseases (in particular Alzheimer’s disease), neurodevelopmental disorders (in particular autism and schizophrenia), and neuropathic pain.
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Cited by
NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain
Matta, J. A., Gu, S., Davini, W. B., Lord, B., Siuda, E. R., Harrington, A. W., & Bredt, D. S. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.008 · Cited by 88
Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins
Maher, M. P., Matta, J. A., Gu, S., Seierstad, M., & Bredt, D. S. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.001 · Cited by 64
Xu, Z.-Q., Zhang, W.-J., Su, D.-F., Zhang, G.-Q., & Miao, C.-Y. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-273 · Cited by 60
Sinha, N., Karche, N. P., Verma, M. K., Walunj, S. S., Nigade, P. B., Jana, G., Kurhade, S. P., Hajare, A. K., Tilekar, A. R., Jadhav, G. R., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01569 · Cited by 30
Zhao, J., Zhang, R., Wang, W., Jiang, S., Liang, H., Guo, C., Qi, J., Zeng, H., & Song, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109880 · Cited by 25
Metadata
- Authors
- Dineley, K. T., Pandya, A. A., & Yakel, J. L.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 36
- Issue
- 2
- Pages
- 96-108
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2010022125
- Cited by
- 450
- References
- 23
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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