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Effects of endocrine disrupting chemicals on in vitro global DNA methylation and adipocyte differentiation
Abstract
Recent studies suggest that endocrine disrupting chemicals (EDCs) may form a risk factor for obesity by altering energy metabolism through epigenetic gene regulation. The goal of this study is to investigate the effects of a range of EDCs with putative obesogenic properties on global DNA methylation and adipocyte differentiation in vitro. Murine N2A and human SK-N-AS neuroblastoma cells and murine preadipocyte fibroblasts (3T3-L1) were exposed to tributyltin (TBT), diethylstilbestrol (DES), bisphenol A (BPA), 2,3,7,8-tetrachlorodibenzo-[p]-dioxin (TCDD), 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153), hexachlorobenzene (HCB), hexabromocyclododecane (HBCD), 2,2',4,4'-tetrabrominated diphenyl ether (BDE-47) , perfluorinated octyl acid (PFOA) and perfluorinated octyl sulfonate (PFOS). A modest decrease in global DNA methylation was observed in N2A cells exposed to 10 μM DES, BPA, TCDD, BDE-47, PCB-153 and 1 μM HCB, but no changes were found in the human SK-N-AS cells. We reveal for the first time that BDE-47 increases adipocyte differentiation in a dose-dependent manner (2.5-25 μM). Adipocyte differentiation was also enhanced by TBT (≥ 10 nM) and BPA (>10 μM) and inhibited by TCDD (≥ 0.1 nM). The other chemicals showed either modest or no effects on adipocyte differentiation at the concentrations tested (PFOA, PFOS and HBCD at 10 μM; PCB-153, 3.4 μM and HCB, 1 μM). This study demonstrates that selected EDCs can induce functional changes in murine adipocyte differentiation in vitro which are accompanied by decreased global DNA methylation.
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“However, the latter finding may be unique to mouse cell lines since the DNA hypomethylating effects of PCB 153 were not observed in the human SK-N-AS neuroblastoma cell line [ 31 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [31]
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“Exposure to the NDL congener PCB 153 decreases DNMT activity in preimplantation mouse blastocytes [ 30 ], and decreases global DNA methylation levels in the N2A murine neuroblastoma cell line [ 31 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [31]
Citations
Cites
Levesque, R. J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-32132-5_447-2 · Cited by 4,060
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
Dolinoy, D. C., Huang, D., & Jirtle, R. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703739104 · Cited by 1,369
Tobi, E. W., Lumey, L. H., Talens, R. P., Kremer, D., Putter, H., Stein, A. D., Slagboom, P. E., & Heijmans, B. T. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp353 · Cited by 1,173
Endocrine Disruptors: From Endocrine to Metabolic Disruption
Casals-Casas, C., & Desvergne, B. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142200 · Cited by 902
Environmental Obesogens: Organotins and Endocrine Disruption via Nuclear Receptor Signaling
Grün, F., & Blumberg, B. (2006) · Endocrinology · doi:10.1210/en.2005-1129 · Cited by 812
Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
Godfrey, K. M., Sheppard, A. M., Gluckman, P. D., Lillycrop, K. A., Burdge, G. C., McLean, C. A., Rodford, J., Slater-Jefferies, J. L., Garratt, E. S., Crozier, S., et al. (2011) · Diabetes · doi:10.2337/db10-0979 · Cited by 761
Bhutani, N., Burns, D. M., & Blau, H. M. (2011) · Cell · doi:10.1016/j.cell.2011.08.042 · Cited by 727
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710
Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates
Grün, F., Watanabe, H., Zamanian, Z., Maeda, L. S., Arima, K., Cubacha, R., Gardiner, D. M., Kanno, J., Iguchi, T., & Blumberg, B. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0367 · Cited by 612
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Lizunkova, P., Engdahl, E., Borbély, G., Gennings, C., Lindh, C. H., Bornehag, C., & Rüegg, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042320 · Cited by 19
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Jala, A., Varghese, B., Kaur, G., Karthikraj, R., Dutta, R., Adela, R., & Borkar, R. M. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-21612-0 · Cited by 15
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Barnett, L. M. A., Kramer, N. E., Buerger, A. N., Love, D. H., Bisesi, J. H., & Cummings, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810044 · Cited by 14
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Agrahari, A., Singh, A., Srivastava, A., Jha, R. R., Patel, D. K., Yadav, S., Srivastava, V. K., & Parmar, D. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.03.022 · Cited by 14
Omichessan, H., Perduca, V., Polidoro, S., Kvaskoff, M., Truong, T., Cano-Sancho, G., Antignac, J., Baglietto, L., Mancini, F. R., & Severi, G. (2022) · Environmental Research · doi:10.1016/j.envres.2022.112788 · Cited by 13
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Legler, J. (2013) · Obesity · doi:10.1002/oby.20478 · Cited by 13
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Cocci, P., Mosconi, G., & Palermo, F. A. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103753 · Cited by 12
Cao, Y., Chen, L., Zhang, Z., Yao, H., Liu, C., Li, S., & Xu, S. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.05.004 · Cited by 12
Tian, J., Xu, H., Zhang, Y., Shi, X., Wang, W., Gao, H., & Bi, Y. (2019) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2019.109579 · Cited by 12
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Ricker, K., Cheng, V., Hsieh, C., Tsai, F. C., Osborne, G., Li, K., Yilmazer-Musa, M., Sandy, M. S., Cogliano, V. J., Schmitz, R., et al. (2024) · International Journal of Toxicology · doi:10.1177/10915818231225161 · Cited by 11
Šrut, M., Sabolić, I., Erdelez, A., Grbin, D., Turk, M. F., Bakarić, R., Peharda, M., & Štambuk, A. (2023) · Toxics · doi:10.3390/toxics11030276 · Cited by 10
Özçağlı, E., Kubíčková, B., & Jacobs, M. N. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1401120 · Cited by 10
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den Broeder, M. J., Ballangby, J., Kamminga, L. M., Aleström, P., Legler, J., Lindeman, L. C., & Kamstra, J. H. (2020) · Epigenetics & Chromatin · doi:10.1186/s13072-020-0329-y · Cited by 10
Self-citationBeck, I. H., Grøntved, A., Palm, C. V. B., Batzella, E., Sigvaldsen, A., Dalgård, C., Jensen, R. C., Nielsen, C., Halldorsson, T. I., & Jensen, T. K. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121394 · Cited by 8
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Han, X., Wang, Y., Chen, T., Wilson, M. J., Pan, F., Wu, X., Rui, C., Chen, D., Tang, Q., & Wu, W. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.05.016 · Cited by 5
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Pu, Y., Ticiani, E., Waye, A. A., Dong, K., Zhang, H., & Veiga‐Lopez, A. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134806 · Cited by 4
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Midoro‐Horiuti, T., & Goldblum, R. M. (2017) · Archives of Asthma Allergy and Immunology · doi:10.29328/journal.haard.1001003 · Cited by 3
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Li, N., Wang, J., Li, K., Yang, P., Wang, Y., Xu, C., He, N., Ji, K., Song, H., Zhang, M., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28591-w · Cited by 1
Velasco, A. M. R., Lesmes, I. B., Díaz‐Perales, A., Gil‐Izquierdo, Á., González‐Muñoz, M. J., Moreno-Arribas, M. V., Baquedano, M. D. P. P., & Sánchez, S. P. (2023) · Food Risk Assess Europe · doi:10.2903/fr.efsa.2023.fr-0011 · Cited by 1
Liu, Z., Qiayimaerdan, A., Fan, Y., Jiang, S.-R., Tuerxuna, Z., Wang, M., & Abudureheman, H. (2024) · Adipocyte · doi:10.1080/21623945.2024.2430717 · Cited by 1
Bainour, K., Monroig, Ó., Ramos-Llorens, M., & Navarro, J. C. (2025) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2025.111164 · Cited by 1
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Wan, K., Wu, D., Xie, G., Li, Y., & Zhang, J. (2024) · Toxics · doi:10.3390/toxics12090665 · Cited by 1
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Goran, M. I. (2016) · CRC Press eBooks · doi:10.1201/9781315370958-21 · Cited by 1
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(2018) · TemaNord · doi:10.6027/tn2018-537 · Cited by 1
Shimpi, P. C. (2015) · Digital Commons - URI (University of Rhode Island) · doi:10.23860/diss-shimpi-prajakta-2015
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Kupsco, A. J., Sjödin, A., Cowell, W., Jones, R. S., Oberfield, S. E., Wang, S., Hoepner, L., Gallagher, D., Baccarelli, A., Goldsmith, J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21069428
Kim, J., Im, J., & Choi, J. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.119754
Farnezi, H. C. M., Lentz, S. B. I., Legler, J., & Kamstra, J. H. (2026) · NAM journal. · doi:10.1016/j.namjnl.2026.100112
Self-citationMenéndez-Pedriza, A., Gawra, J., Kamstra, J. H., Faria, M., Bellot, M., Gómez‐Canela, C., Raldúa, D., Legler, J., Jaumot, J., Piña, B., et al. (2026) · Current Zoology · doi:10.1093/eep/dvag031
Self-citationNg, R. R., Gao, Y., Xu, Y., & Lau, A. T. Y. (2026) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-3-032-32838-0_4
Metadata
- Authors
- Bastos Sales, L., Kamstra, J. H., Cenijn, P. H., van Rijt, L. S., Hamers, T., & Legler, J.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Legler, J.
- Venue
- Toxicology in Vitro
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 27
- Issue
- 6
- Pages
- 1634-1643
- ISSN
- 0887-2333 (ISSN-L)
- OpenAlex
- W2015008373
- Cited by
- 181
- References
- 48
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 27 · 2023: 7 · 2022: 13 · 2021: 14 · 2020: 14 · 2019: 10 · 2018: 21 · 2017: 18 · 2016: 15 · 2015: 10 · 2014: 23 · 2013: 1
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology in Vitro (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- VU Research Portal (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- endocrine disruptors, global DNA methylation, adipogenesis, obesity, epigenetic regulation, bisphenol A, diethylstilbestrol, tributyltin, 2,3,7,8-tetrachlorodibenzo-p-dioxin, BDE-47, hexabromocyclododecane, PCB 153, hexachlorobenzene
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Caprylates, Cell Differentiation, Diethylstilbestrol, Environmental Pollutants, Fluorocarbons, Humans, Hydrocarbons, Brominated, Hydrocarbons, Chlorinated, Phenols, Trialkyltin Compounds, Adipocytes, Alkanesulfonic Acids, DNA Methylation, 3T3-L1 Cells, Cell Line, Tumor, Mice, Endocrine Disruptors, Halogenated Diphenyl Ethers
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