The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic–pituitary–testicular axis
Open accessAbstract
Reproductive physiology involves complex biological processes that can be disrupted by exposure to environmental contaminants. The effects of bisphenol A (BPA) on spermatogenesis and sperm quality is still unclear. The objective of this study was to investigate the reproductive toxicity of BPA at dosages considered to be safe (5 or 25mg BPA/kg/day). We assessed multiple sperm parameters, the relative expression of genes involved in the central regulation of the hypothalamic-pituitary-testicular axis, and the serum concentrations of testosterone, estradiol, LH and FSH. BPA exposure reduced sperm production, reserves and transit time. Significant damage to the acrosomes and the plasma membrane with reduced mitochondrial activity and increased levels of defective spermatozoa may have compromised sperm function and caused faster movement through the epididymis. BPA exposure reduced the serum concentrations of testosterone, LH and FSH and increased the concentration of estradiol. The relative gene expression revealed an increase in gonadotropin releasing hormone receptor (Gnrhr), luteinizing hormone beta (Lhb), follicle stimulating hormone beta (Fshb), estrogen receptor beta (Esr2) and androgen receptor (Ar) transcripts in the pituitary and a reduction in estrogen receptor alpha (Esr1) transcripts in the hypothalamus. In this study, we demonstrated for the first time that adult male exposure to BPA caused a reduction in sperm production and specific functional parameters. The corresponding pattern of gene expression is indicative of an attempt by the pituitary to reestablish normal levels of LH, FSH and testosterone serum concentrations. In conclusion, these data suggest that at dosages previously considered nontoxic to reproductive function, BPA compromises the spermatozoa and disrupts the hypothalamic-pituitary-gonadal axis, causing a state of hypogonadotropic hypogonadism.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Knobil and Neill's Physiology of Reproduction
(2015) · Elsevier eBooks · doi:10.1016/c2011-1-07288-0 · Cited by 1,272
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Welshons, W. V., Thayer, K. A., Judy, B. M., Taylor, J. A., Curran, E. M., & vom Saal, F. S. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5494 · Cited by 905
Vom Saal, F. S., Cooke, P. S., Buchanan, D. L., Palanza, P., Thayer, K. A., Nagel, S. C., Parmigiani, S., & Welshons, W. V. (1998) · Toxicology and Industrial Health · doi:10.1177/074823379801400115 · Cited by 757
Abnormal Morphology of Bovine Spermatozoa,
Galloway, D. (1992) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1992.tb09864.x · Cited by 609
Akingbemi, B. T., Sottas, C. M., Koulova, A. I., Klinefelter, G. R., & Hardy, M. P. (2004) · Endocrinology · doi:10.1210/en.2003-1174 · Cited by 516
Antioxidant strategies in the epididymis
Vernet, P., Aitken, R. J., & Drevet, J. R. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.10.069 · Cited by 513
The effects of cryopreservation on sperm morphology, motility and mitochondrial function
O'Connell, M., McClure, N., & Lewis, S. E. M. (2002) · Human Reproduction · doi:10.1093/humrep/17.3.704 · Cited by 510
Rodriguez-Mozaz, S., López de Alda, M. J., & Barceló, D. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.06.040 · Cited by 407
Cited by
The adverse health effects of bisphenol A and related toxicity mechanisms
Ma, Y., Liu, H., Wu, J., Yuan, L., Wang, Y., Du, X., Wang, R., Marwa, P. W., Petlulu, P., Chen, X., et al. (2019) · Environmental Research · doi:10.1016/j.envres.2019.108575 · Cited by 819
Bisphenol A (BPA) and cell signaling pathways
Murata, M., & Kang, J.-H. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.002 · Cited by 361
The hazardous threat of Bisphenol A: Toxicity, detection and remediation
Tarafdar, A., Sirohi, R., Balakumaran, P. A., Reshmy, R., Madhavan, A., Sindhu, R., Binod, P., Kumar, Y., Kumar, D., & Sim, S. J. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.127097 · Cited by 361
Effects of bisphenol A and its analogs on reproductive health: A mini review
Siracusa, J. S., Yin, L., Measel, E., Liang, S., & Yu, X. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.06.005 · Cited by 341
An insight into bisphenol A, food exposure and its adverse effects on health: A review
Manzoor, M. F., Tariq, T., Fatima, B., Sahar, A., Tariq, F., Munir, S., Khan, S., Nawaz Ranjha, M. M. A., Sameen, A., Zeng, X.-A., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1047827 · Cited by 293
Metadata
- Authors
- Wisniewski, P., Romano, R. M., Kizys, M. M. L., Oliveira, K. C., Kasamatsu, T., Giannocco, G., Chiamolera, M. I., Dias-da-Silva, M. R., & Romano, M. A.
- Venue
- Toxicology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 329
- Pages
- 1-9
- ISSN
- 0300-483X (ISSN-L)
- OpenAlex
- W2045344984
- Cited by
- 270
- References
- 44
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wisniewski, P., Romano, R. M., Kizys, M. M. L., Oliveira, K. C., Kasamatsu, T., Giannocco, G., Chiamolera, M. I., Dias-da-Silva, M. R., & Romano, M. A. (2015). Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic–pituitary–testicular axis. Toxicology. https://doi.org/10.1016/j.tox.2015.01.002
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