In vivo effects of bisphenol A in laboratory rodent studies
Open accessAbstract
Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10-1000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.
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BPA can bind to estrogen receptors at low concentration and affects normal hormonal regulation and endocrine function.
“BPA can bind to estrogen receptors (ERs) at low concentration and thus affects normal hormonal regulation and endocrine function [1].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [1]
Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889 · see citing works
Exposure to bisphenol A advances puberty
Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., & vom Saal, F. S. (1999) · Nature · doi:10.1038/44517 · Cited by 820 · see citing works
Self-citationRole of estrogens in adipocyte development and function
Cooke, P. S., & Naaz, A. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422901107 · Cited by 370 · see citing works
Palanza, P. L., Howdeshell, K. L., Parmigiani, S., & vom Saal, F. S. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3415 · Cited by 268 · see citing works
Bisphenol A affects glucose transport in mouse 3T3‐F442A adipocytes
Sakurai, K., Kawazuma, M., Adachi, T., Harigaya, T., Saito, Y., Hashimoto, N., & Mori, C. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705520 · Cited by 156 · see citing works
Effects of Perinatal Exposure to Bisphenol A on Play Behavior of Female and Male Juvenile Rats
Dessì-Fulgheri, F., Porrini, S., & Farabollini, F. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s3403 · Cited by 146 · see citing works
Self-citationPubertal exposure to estrogenic chemicals affects behavior in juvenile and adult male rats
Della Seta, D., Minder, I., Belloni, V., Aloisi, A. M., Dessì-Fulgheri, F., & Farabollini, F. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.03.015 · Cited by 86 · cited 13× · see citing works
“Aloisi AM, Della Seta D, Rendo C, Ceccarelli I, Scaramuzzino A, Farabollini F. Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats.”
BackgroundResultInfluentialSelf-citation
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Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L. C., Hauser, R., Prins, G. S., Soto, A. M., Zoeller, R. T., & Gore, A. C. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0002 · Cited by 4,585 · see citing works
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209 · see citing works
Bisphenol A and human health: A review of the literature
Rochester, J. R. (2013) · Reproductive Toxicology · doi:10.1016/j.reprotox.2013.08.008 · Cited by 2,018 · see citing works
Exposure of the U.S. Population to Bisphenol A and 4- <i>tertiary</i> -Octylphenol: 2003–2004
Calafat, A. M., Ye, X., Wong, L.-Y., Reidy, J. A., & Needham, L. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10753 · Cited by 1,743 · see citing works
Bisphenol Analogues Other Than BPA: Environmental Occurrence, Human Exposure, and Toxicity—A Review
Chen, D., Kannan, K., Tan, H., Zheng, Z., Feng, Y.-L., Wu, Y., & Widelka, M. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.5b05387 · Cited by 1,704 · see citing works
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
Self-citationPhthalates and other additives in plastics: human exposure and associated health outcomes
Meeker, J. D., Sathyanarayana, S., & Swan, S. H. (2009) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0268 · Cited by 835 · see citing works
Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013
Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H. S., Swan, S. H., VandeVoort, C. A., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307728 · Cited by 555 · see citing works
Kundakovic, M., Gudsnuk, K., Franks, B., Madrid, J., Miller, R. L., Perera, F. P., & Champagne, F. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214056110 · Cited by 490 · see citing works
DNA methylation of BDNF as a biomarker of early-life adversity
Kundakovic, M., Gudsnuk, K., Herbstman, J. B., Tang, D., Perera, F. P., & Champagne, F. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408355111 · Cited by 426 · see citing works
Delfosse, V., Grimaldi, M., Pons, J.-L., Boulahtouf, A., le Maire, A., Cavailles, V., Labesse, G., Bourguet, W., & Balaguer, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203574109 · Cited by 405 · see citing works
Prenatal Bisphenol A Exposure and Child Behavior in an Inner-City Cohort
Perera, F., Vishnevetsky, J., Herbstman, J. B., Calafat, A. M., Xiong, W., Rauh, V., & Wang, S. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1104492 · Cited by 332 · see citing works
Lead and PCBs as Risk Factors for Attention Deficit/Hyperactivity Disorder
Eubig, P. A., Aguiar, A., & Schantz, S. L. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0901852 · Cited by 277 · see citing works
Bisphenol A: an emerging threat to female fertility
Pivonello, C., Muscogiuri, G., Nardone, A., Garifalos, F., Provvisiero, D. P., Verde, N., de Angelis, C., Conforti, A., Piscopo, M., Auriemma, R. S., et al. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-019-0558-8 · Cited by 263 · see citing works
Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.02.012 · Cited by 211 · see citing works
Impact of chemical endocrine disruptors and hormone modulators on the endocrine system
Guarnotta, V., Amodei, R., Frasca, F., Aversa, A., & Giordano, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105710 · Cited by 171 · see citing works
Hanna, C. W., Bloom, M. S., Robinson, W. P., Kim, D., Parsons, P. J., vom Saal, F. S., Taylor, J. A., Steuerwald, A. J., & Fujimoto, V. Y. (2012) · Human Reproduction · doi:10.1093/humrep/des038 · Cited by 163 · see citing works
Self-citationBisphenol A Exposure in Children With Autism Spectrum Disorders
Stein, T. P., Schluter, M. D., Steer, R. A., Guo, L., & Ming, X. (2015) · Autism Research · doi:10.1002/aur.1444 · Cited by 151 · see citing works
Cao, J., Rebuli, M. E., Rogers, J., Todd, K. L., Leyrer, S. M., Ferguson, S. A., & Patisaul, H. B. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft035 · Cited by 141 · see citing works
Patel, B. B., Raad, M., Sebag, I. A., & Chalifour, L. E. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft026 · Cited by 114 · see citing works
Low-dose effects of bisphenol A on early sexual development in male and female rats
Christiansen, S., Axelstad, M., Boberg, J., Vinggaard, A. M., Pedersen, G. A., & Hass, U. (2014) · Reproduction · doi:10.1530/rep-13-0377 · Cited by 108 · see citing works
Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices
Auner, A. W., Tasneem, K. M., Markov, D. A., McCawley, L. J., & Hutson, M. S. (2019) · Lab on a Chip · doi:10.1039/c8lc00796a · Cited by 87 · see citing works
High dose bisphenol A impairs hippocampal neurogenesis in female mice across generations
Jang, Y. J., Park, H. R., Kim, T. H., Yang, W.-J., Lee, J.-J., Choi, S. Y., Oh, S. B., Lee, E., Park, J.-H., Kim, H.-P., et al. (2012) · Toxicology · doi:10.1016/j.tox.2012.03.007 · Cited by 82 · see citing works
Ferguson, S. A., Law, C. D., & Abshire, J. S. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr201 · Cited by 54 · see citing works
Gioiosa, L., Palanza, P., Parmigiani, S., & vom Saal, F. S. (2015) · Dose-Response · doi:10.1177/1559325815610760 · Cited by 41 · see citing works
vom Saal, F. S. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-0211 · Cited by 38 · see citing works
Kumar, D., & Thakur, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110482 · Cited by 37 · see citing works
RetractedFerguson, S. A., Law, C. D., & Kissling, G. E. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu077 · Cited by 32 · see citing works
Chen, X., Wang, Y., Xu, F., Wei, X., Zhang, J., Wang, C., Wei, H., Xu, S., Yan, P., Zhou, W., et al. (2017) · Neural Plasticity · doi:10.1155/2017/5196958 · Cited by 24 · see citing works
“BPA can bind to estrogen receptors (ERs) at low concentration and thus affects normal hormonal regulation and endocrine function [1].”
BackgroundPhytobiomass-based nanoadsorbents for sequestration of aquatic emerging contaminants: An Overview
Sharma, A., Kumar, N., Mudhoo, A., & Garg, V. K. (2023) · Journal of Environmental Chemical Engineering · doi:10.1016/j.jece.2023.109506 · Cited by 23 · see citing works
- Authors
- Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S.
- Affiliations
- Columbia Environmental Research Center (US)
- Environmental Protection Agency (US)
- University of Siena (IT)
- National Institutes of Health (US)
- Tufts University (US)
- Charité – Universitätsmedizin Berlin (DE)
- North Carolina State University (US)
- Carleton College (US)
- Corresponding author
- Richter, Catherine A.
- Venue
- Reproductive Toxicology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 24
- Issue
- 2
- Pages
- 199-224
- ISSN
- 0890-6238 (ISSN-L)
- PMC
- PMC2151845
- OpenAlex
- W2114729638
- Cited by
- 1,147
- References
- 7
- Citations by year
- 2026: 19 · 2025: 28 · 2024: 43 · 2023: 31 · 2022: 38 · 2021: 60 · 2020: 64 · 2019: 78 · 2018: 68 · 2017: 91 · 2016: 80 · 2015: 79 · 2014: 95 · 2013: 90 · 2012: 75
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Reproductive Toxicology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Environmental Health Sciences (R01ES011283)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- bisphenol A, low-dose exposure, early life exposure, endocrine disruption, estrogenic activity, diethylstilbestrol, ethinyl estradiol, male reproductive tract, brain development, female reproductive system, immunological effects, metabolic effects, rodent studies
- MeSH terms
- Bisphenol A Compounds, Animals, Benzhydryl Compounds, Dose-Response Relationship, Drug, Female, Male, Phenols, Sexual Behavior, Animal, Molecular Structure, Mice, Rats, Endocrine Disruptors
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