Acoustic stress induces long term severe intestinal inflammation in the mouse
Open accessAbstract
The influence of noise on the presentation and progression of inflammatory bowel diseases has been poorly analyzed. We designed this study to investigate immediate and late effects of acoustic stress (AS) on small intestine. To this aim, CBA/J, BALB/c and DBA/2 mice were divided into AS and control groups. AS mice were exposed to noise (300Hz-70dB) during 24hs and randomized into: A) Acute effects group: mice were killed after AS; L) Late effects group: mice were killed 3 weeks after AS and O) Over-exposed effects group: mice were submitted to AS once a week during a month and killed. Small intestine sections were histologically examined. The expression of cytokines (IL-17, IL-22, TNF-α, INF-ɣ and TGF-β), CCL-25 and Ki67 was studied by immunohistochemistry and immunofluorescence techniques. "A" group displayed short and fragmented villi, diminished number of lamina propria cells, leucocyte infiltration, higher number of goblet cells and predominance of IL-17 expression. "L" group showed epithelial proliferative foci (CCL25+Ki67+) and increased TNFα/TGF-β expression. Tissue damage was aggravated in "O" group. In conclusion, AS is able to trigger a severe intestinal inflammatory process in healthy mice, which spontaneously amplifies and perpetuates. Noise might be harmful to humans by aggravating inflammatory bowel diseases.
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Acoustic stress has been found to cause severe enteritis in the healthy intestinal tract.
“In addition, acoustic stress has been found to cause severe enteritis in the healthy intestinal tract (86).”
From Stress triggers flare of inflammatory bowel disease in children and adults (2019) · cites this paper as [86]
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- Cătană, C., Berindan Neagoe, I., Cozma, V., Magdaş, C., Tăbăran, F., Dumitraşcu, D., 2015. IL-17 and IL-23 in the pathogenesis of inflammatory bowel disease. World J. Gastroenterol. 21 (19), 5823-5830.
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Stress triggers flare of inflammatory bowel disease in children and adults
Sun, Y., Li, L., Xie, R., Wang, B., Jiang, K., & Cao, H. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00432 · Cited by 171 · see citing works
- Authors
- Miranda, S., & Roux, M. E.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Miranda, Silvia
- ORCID
- Miranda, Silvia
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 280
- Pages
- 1-9
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W2742016582
- Cited by
- 16
- References
- 57
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 5 · 2019: 4 · 2018: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Secretaría de Ciencia y Técnica, Universidad de Buenos Aires (20020150100205BA)
- Consejo Nacional de Investigaciones Científicas y Técnicas (11220150100333CO, PIP 2015–2017)
- Universidad de Buenos Aires
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Health Professions › Speech and Hearing › Noise Effects and Management
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- acoustic stress, noise exposure, intestinal inflammation, inflammatory bowel disease, small intestine, IL-17, TNF-α, TGF-beta, CCL25, Ki-67, epithelial cell proliferation, goblet cells, lamina propria, leukocyte infiltration, chronic noise exposure
- MeSH terms
- Animals, Female, Gene Expression Regulation, Inflammation, Intestinal Diseases, Male, Mice, Inbred Strains, Noise, Random Allocation, Stress, Psychological, Time Factors, Cytokines, Mice
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