Cited by 1,054Ubiquitin and proteasome pathwaysNF-κB Signaling PathwaysProtein Degradation and Inhibitors

The increasing complexity of the ubiquitin code

Yau, Richard, Rape, Michael·2016·Nature Cell Biology

Abstract

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex polymeric chains, with different types of ubiquitylation often eliciting distinct outcomes. The recent identification of novel chain topologies has improved our understanding of how ubiquitylation establishes precise communication within cells. Here, we discuss how the increasing complexity of ubiquitylation is employed to ensure robust and faithful signal transduction in eukaryotic cells.

Integrity signals

Registry

Crossref · 10.1038/ncb3358

Cites

151 of 151 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • More than 600 E3 ligases in the human genome fall into different classes depending on which ubiquitin ligation strategy they use.

    “the more than 600 E3 ligases in the human genome fall into different classes, depending on which ubiquitin ligation strategy they use (reviewed in refs80,108–110).”

    From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [108]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yau, R., & Rape, M.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Nature Cell Biology
Published
2016-05-27
Volume
18
Issue
6
Pages
579-586
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
OpenAlex
W2398731353
Cited by
1,054
References
151
Citations by year
2026: 71 · 2025: 91 · 2024: 124 · 2023: 121 · 2022: 110 · 2021: 114 · 2020: 117 · 2019: 108 · 2018: 84 · 2017: 101 · 2016: 13
FWCI
9.11
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
Keywords
ubiquitination, polyubiquitin chains, signal transduction, protein modification, cell division, cell differentiation
MeSH terms
Animals, Humans, Models, Molecular, Signal Transduction, Ubiquitin, Ubiquitination

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review