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Cited by 93Medication Adherence and ComplianceRenal Transplantation Outcomes and TreatmentsOrgan and Tissue Transplantation Research

Nonadherent Behaviors After Solid Organ Transplantation

Germani, G., Lazzaro, S., Gnoato, F., Senzolo, M., Borella, V., Rupolo, G., Cillo, U., Rigotti, P. +5 more·2011·Transplantation Proceedings
DOI 10.1016/j.transproceed.2010.09.103
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Abstract

Background and aim The effectiveness of any treatment depends not only on the choice of therapy, but also, to a large extent, on the patient's active cooperation. Adherence to medical prescriptions and particularly to immunosuppressive therapy is crucial to prevent medical complications that negatively influence graft function and patient survival after organ transplantation. The aim of this study was to assess, among patients who underwent solid organ transplantation, nonadherent behaviors (NAB) to immunosuppressive therapy, to correct lifestyle, and to general medical prescriptions. Materials and methods We evaluated patients who underwent solid organ transplantation from March 2008 to June 2009. All participants completed an anonymous 15-item questionnaire to assess NAB. Results We enrolled 218 organ transplant patients: 103 liver, 50 kidney, 52 heart, and 13 lung. There were 152 men and the overall age was 52.2 ± 0.8 years (mean ± standard deviation [SD]) time from transplantation, 83.6 ± 4.5 months (mean ± SD). Overall 37.9%, 38.8%, and 12.8% of patients reported nonadherence to immunosuppressive therapy, to correct lifestyle, and to general medical prescriptions, respectively. Considering nonadherence to immunosuppressive therapy and to general prescriptions, the percentage of kidney transplant patients who referred NAB was significantly lower compared with other organ transplant patients (P = .008 and P = .04, respectively). Nonadherent patients to immunosuppressive therapy and to general medical prescriptions displayed a longer interval from transplantation compared with adherent patients (P = .02 and P = .03, respectively). Among patients nonadherent to the correct lifestyle, the rates of men and of patients with disability pension were significantly higher compared to adherent patients (P = .001 and P = .002, respectively). Conclusions Poor adherence to medical prescriptions and to adequate lifestyle is common among organ transplant patients, especially those who have undergone liver transplantation. Psychoeducational interventions for transplanted patients and their families are needed to improve adherence.

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  • Other groups suggested that in addition to medication adherence, other dimensions such as health perception, diet, exercise, and keeping appointments and contact with the transplant center might influence outcome.

    “Other groups[41–43] suggested that in addition to medication adherence, other dimensions, such as health perception, diet, exercise, and keeping appointments and contact with the transplant center might influence outcome.”

    From Adherence is associated with a favorable outcome after lung transplantation (2019) · cites this paper as [43]

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Authors
Germani, G., Lazzaro, S., Gnoato, F., Senzolo, M., Borella, V., Rupolo, G., Cillo, U., Rigotti, P., Feltrin, G., Loy, M., Martin, A., Sturniolo, G. C., & Burra, P.
Affiliations
  • Azienda Ospedale - Università Padova (IT)
  • Regione del Veneto (IT)
Corresponding author
Burra, P.
ORCID
Venue
Transplantation Proceedings
Publisher
Elsevier BV
Published
2011-01
Volume
43
Issue
1
Pages
318-323
ISSN
0041-1345 (ISSN-L)
DOI
10.1016/j.transproceed.2010.09.103
OpenAlex
W1981316034
Cited by
91
References
26
Citations by year
2025: 5 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 9 · 2014: 8 · 2013: 5 · 2012: 4
FWCI
5.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Transplantation Proceedings (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
  • Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
Keywords
medication non-adherence, solid organ transplantation, immunosuppressive therapy, lifestyle modification, liver transplantation, kidney transplantation, heart transplantation, lung transplantation, psychoeducational intervention, graft function, patient survival
MeSH terms
Female, Humans, Immunosuppressive Agents, Life Style, Male, Middle Aged, Patient Compliance, Organ Transplantation

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