The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies
Open accessAbstract
CDK4/6 inhibitors have emerged as a powerful class of agents with clinical activity in a number of malignancies. Targeting the cell cycle represents a core attack on a defining feature of cancer. However, the mechanisms through which selective CDK4/6 targeted agents act has few parallels in the current pharmaceutical armamentarium against cancer. Notably, CDK4/6 inhibitors act downstream of most mitogenic signaling cascades, which have implications both related to clinical efficacy and resistance. Core knowledge of cell cycle processes has provided insights into mechanisms of intrinsic resistance to CDK4/6 inhibitors; however, the basis of acquired resistance versus durable response is only beginning to emerge. This review focuses on the mechanism of action and biomarkers to direct the precision use of CDK4/6 inhibitors and rationally-developed combination therapies.
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Cited by
CDK4/6 inhibition in breast cancer: current practice and future directions
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Coffman, L. G., Orellana, T. J., Liu, T., Frisbie, L. G., Normolle, D., Griffith, K., Uppal, S., McLean, K., Berger, J., Boisen, M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.160573 · Cited by 17
Resistance Mechanisms to Cyclin-Dependent Kinase Inhibitors
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Metadata
- Authors
- Knudsen, E. S., & Witkiewicz, A. K.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 3
- Issue
- 1
- Pages
- 39-55
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W2568050301
- Cited by
- 285
- References
- 147
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Knudsen, E. S., & Witkiewicz, A. K. (2017). The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies. Trends in Cancer. https://doi.org/10.1016/j.trecan.2016.11.006
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