The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase
Abstract
Cancer cells display a high rate of glycolysis in the presence of oxygen to promote proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic glycolysis in cancer via three key enzymes - phosphoenolpyruvate carboxykinase (PEPCK), fructose-1,6-bisphosphatase (FBPase), and glucose-6-phosphatase (G6Pase). Recent studies have revealed that, in addition to metabolic regulation, these enzymes also play a role in signaling, proliferation, and the cancer stem cell (CSC) tumor phenotype. Multifaceted regulation of PEPCK, FBPase, and G6Pase through transcription, epigenetics, post-translational modification, and enzymatic activity is observed in different cancers. We review here the function and regulation of key gluconeogenic enzymes and new therapeutic opportunities.
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Cites
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Cited by
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation
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FOXO transcription factor family in cancer and metastasis
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The role of lipid metabolic reprogramming in tumor microenvironment
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Metabolic reprogramming in triple-negative breast cancer
Wang, Z., Jiang, Q., & Dong, C. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0210 · Cited by 248
“Ubiquitous loss of FBP1 in TNBC is required for the maintenance of aerobic glycolysis and the CSC phenotype 91,93 .”
Background
Metadata
- Authors
- Wang, Z., & Dong, C.
- Venue
- Trends in Cancer
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 5
- Issue
- 1
- Pages
- 30-45
- ISSN
- 2405-8025 (ISSN-L)
- 2405-8033
- OpenAlex
- W2905965925
- Cited by
- 293
- References
- 100
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase. https://app.cochat.ai/papers/10.1016/j.trecan.2018.11.003
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- Wang, Z., & Dong, C. (2019). Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase. Trends in Cancer. https://doi.org/10.1016/j.trecan.2018.11.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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