The Structure and Function of DNA G-Quadruplexes

Cited by (706)

Items 501–600 of 706

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  2. Discovery of a Novel Dual-Targeting c-MYC and BCL-2 promoter G- Quadruplexes Ligand for the Treatment of Cervical cancer
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  3. Thermodynamic control of gene regulation
    James W. Wells, T. Chalikian · 2025 · QRB Discovery
  4. Stabilization of DNA G-quadruplexes on the 5'-flanking region of CYP3A4 promotes transcription.
    Seiya Takemoto, Itsuki Yokoseki, Seigo Shuto, Masataka Nakano, T. Fukami, Miki Nakajima · 2025 · Biochemical Pharmacology
  5. G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides
    Prakash Kharel, Nupur Bhatter, Safiyah Zubair, Shawn M. Lyons, Paul J. Anderson, Pavel Ivanov · 2025 · Nucleic Acids Research
  6. The effect of prolonged G-quadruplex stabilization on the functions of human cells
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  8. G-quadruplex structure in plants and insects and potential applications in pest control
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  9. Tandemly Repeated G-Quadruplex Structures in the Pseudorabies Virus Genome: Implications for Epiberberine-Based Antiviral Therapy
    Songjie Fan, Xiao-Tian Chang, Yan Qiao, Xiaoxiao Zhao, Jia-Fu Zhao, Heshui Zhu, Yingqian Han, Chao Zhang · 2025 · International Journal of Molecular Sciences
  10. How Do Molecular Crowders Influence Ligand Binding Kinetics with G-Quadruplex DNA? The Role of Bound Water
    Parvez Alam, Ajay Kumar Chand, Harsh Sahu, Mostofa Ataur Rohman, Ndege Simisi Clovis, Deepika Sardana, Sanjay Puri, Sobhan Sen · 2025 · The Journal of Physical Chemistry B
  11. The histone deacetylase inhibitor Scriptaid targets G-quadruplexes
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  12. Knot-knot chronicles: unveiling the G-quadruplexes
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  13. Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions
    Gianmarco Gualtieri, Emanuele Liborio Citriniti, R. Rocca, Valentina Arciuolo, J. Amato, Antonio Randazzo, Stefano Alcaro · 2024 · Molecules
  14. Study of Structural Features of 5S rDNA Non-Transcribed Spacers of Citrus sinensis and C. reticulata
    O. S. Alexandrov, D. Romanov · 2024 · Moscow University Biological Sciences Bulletin
  15. A Novel G-Quadruplex Structure within Apolipoprotein E Promoter: A New Promising Target in Cancer and Dementia Fight?
    Valentina Pirota, Angela Dello Stritto, Lisa Rita Magnaghi, Raffaela Biesuz, Filippo Doria, Mariella Mella, Mauro Freccero, Emmanuele Crespan · 2024 · ACS Omega
  16. Differential binding of curcumin with chair and basket type anti-parallel DNA G-quadruplexes
    Pabitra Mandal, Priyabrata Das, Sudipta Bhowmik, S. Pramanik · 2024 · Journal of Photochemistry and Photobiology A: Chemistry
  17. Enzyme-responsive aptasensing based on the ATP aptamer and benzothiazole-coumarin G-quadruplex fluorescent probe for label-free detection of adenosine deaminase activity and its inhibitor
    Yuxiang Xia, Hong-Yu Li, Yating Lu, Yanfei Zhang, Kai-Xin Xue, Jiaheng Zhang, Yujie Zhao, Xingyu Luo · 2024 · Microchemical journal (Print)
  18. Unravelling the hydrogen bonding patterns in telomeric G-quadruplexes: from structure to function*
    Eugene S. Kryachko, Preston J. MacDougall, Skye Neal · 2024 · Molecular Physics
  19. Suppression of CTC1 inhibits hepatocellular carcinoma cell growth and enhances RHPS4 cytotoxicity
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  20. Strategy for modeling higher-order G-quadruplex structures recalcitrant to NMR determination.
    T. Sabo, John O. Trent, Jonathan B. Chaires, Robert C. Monsen · 2024 · Methods
  21. Balancing act: BRCA2's elaborate management of telomere replication through control of G‐quadruplex dynamicity
    So Young Joo, Keewon Sung, Hyun‐Sook Lee · 2024 · BioEssays
  22. Biotinylated cyclic naphthalene diimide as a searching tool for G4 sites on the genome
    Satoshi Fujii, Shinobu Sato, Ryuki Hidaka, Shigeori Takenaka · 2024 · Analytical Sciences
  23. A bichromophoric squaraine based NIR fluorescent probe for G-quadruplex in living cells
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  24. Small-molecule-based regulation of gene expression in human astrocytes upon both positive and negative actuations of G-quadruplex control systems
    M. J. Vijay Kumar, Jérémie Mitteaux, Zi Wang, Ellery Wheeler, Nitin Tandon, Sung-Yun Jung, R. Hudson, D. Monchaud, Andrey S. Tsvetkov · 2024 · bioRxiv
  25. Local Genomic Instability of the SpTransformer Gene Family in the Purple Sea Urchin Inferred from BAC Insert Deletions
    Megan A. Barela Hudgell, F. Momtaz, Abiha Jafri, Max A. Alekseyev, L. Smith · 2024 · Genes
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  27. Structural Antagonism-Aided Conformational Regulation Enables an Aptamer-Loop G-Quadruplex Modular Sensor of β-Lactoglobulin.
    Xinxin Wang, Ning Xu, Long-Jiao Zhu, He Yang, Chen Li, Hong-Tao Tian, Wen-Tao Xu · 2024 · Small
  28. Recognition of human telomeric G-quadruplex DNA by 1,5-disubstituted diethyl-amido anthraquinone derivative in different ion environments causing thermal stabilization and apoptosis
    Anjana Kumari, Kumud Pandav, Mala Nath, Ritu Barthwal, Rama Krishna Peddinti · 2024 · Journal of Biomolecular Structure and Dynamics
  29. Helquat dyes targeting G-quadruplexes as a new class of anti-HIV-1 inhibitors
    Marcela Pávová, Paul Eduardo Reyes‐Gutierrez, Jaroslav Kozák, Juraj Dobiáš, Yevgen P. Yurenko, Martin Lepšı́k, Filip Teplý, Jan Weber · 2023 · Scientific Reports
  30. Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes
    D. Dobrovodsky, A. Daňhel, Emmanuelle Mothes-Martin, G. Pratviel, D. Renčiuk, J. Mergny, M. Fojta · 2023 · Electrochimica Acta
  31. G-quadruplex and 8-oxo-7,8-dihydroguanine across the genome: methodologies and crosstalk
    Jiao An, Mengdie Yin, Jinchuan Hu · 2022 · Genome Instability & Disease
  32. A new automatic method for human coding and non-coding zones characterization and classification based on FCGR coding and CNN classifier
    Feriel Ben Nasr, Afef Elloumi Oueslati · 2022 · International Conference on Advanced Technologies for Signal and Image Processing
  33. A transposon‐introduced G‐quadruplex motif is selectively retained and constrained to downregulate CYP321A1
    Zhong-Yuan Deng, Yuting Zhang, Chao Gao, W. Shen, Shan Wang, X. Ni, Si-Yuan Liu, Xian-Chun Li · 2022 · Insect Science
  34. The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands
    E. Luteran, P. Paukstelis · 2021 · bioRxiv
  35. Transcription factor recruitment by parallel G-quadruplexes to promote transcription: the case of herpes simplex virus-1 ICP4
    I. Frasson, Paola Soldà, M. Nadai, Sara Lago, S. Richter · 2020 · bioRxiv
  36. Transposon targeting non-coding RNA transcription targets G/C-rich tracts and is facilitated by an intrinsically disordered protein in Tetrahymena
    Cai, Xia, Liu, Yike, Li, Jialuo, Zhao, Zhuoran, Yao, Xinyu, Zhai, Zhihao, Liucong, Mingmei, Liu, Yujie, Wang, Xue, Mochizuki, Kazufumi et al. · 2026 · Science China Life Sciences
  37. Structural insights into the binding of CX-5461 and MTR-106 to G-quadruplex DNA
    Yubo Li, Kefu Liu, X X Hu, Jing Deng, Wenxian Lan, Hongjuan Xue, Wei Tang, Chunyang Cao · 2026 · Nucleic Acids Research
  38. The G-force in the genome: Unknowns on the functional flairs of DNA G-quadruplexes
    Irene Gallina, Sara N. Richter · 2026 · PLoS Biology
  39. Sex-linked helicases DDX3X and DDX3Y regulate G-quadruplex-associated stress in neurons
    Rocio Diaz Escarcega, V. J., Ashlee Arizmendez, Chun-Feng Tan, Akihiko Urayama, S. Marrelli, Rodrigo Morales, J. Wefel, Chun-Chao Zhang, Louise D. Mccullough et al. · 2026 · Cell Death and Disease
  40. Detangling knots: the intricate roles of G-quadruplexes in herpesvirus replication
    Shea A. Lowery, Sarah A. Gordon, Ananya Paul, Rachel S. Hill, Alex S. Holehouse, Elizabeth B. Draganova · 2026 · Journal of Virology
  41. Piperine as a Multifunctional Epigenetic Modulator: Integrative Molecular Insights into Cancer and Chronic Disease Therapy
    Andrés Alarcón, Catherine Meza, Carolina C. Añazco, Marcela Sepúlveda, Sebastián Alarcón, Sharin Valdivia · 2026 · International Journal of Molecular Sciences
  42. CTCF directly binds G-quadruplex structures to regulate genome topology and gene expression
    Daniela Samaniego-Castruita, Isabella Han, Roxroy C. Morgan, S. Carpenter, Bryce Williams, Abhijit Chakraborty, Ishwar Radhakrishnan, Ferhat Ay, Samuel A. Myers, Anjana Rao et al. · 2026 · Proceedings of the National Academy of Sciences of the United States of America
  43. Probing the Structure and Dynamics of Telomeric G-Quadruplexes with Thienoguanosine, a Fluorescent Analogue of Guanosine.
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  44. iDualG4: A Dual-Channel Deep Learning Framework for Predicting In Vivo G-Quadruplexes
    Haitao Li, Li Dong, Yue Jia, Chun-Hou Zheng, Pi Wei · 2026 · Biomolecules
  45. The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexes
    Alison Harrod, Hugang Feng, Nagham Ghaddar, Federica Schiavoni, Karen A. Lane, Lillian Wu, Pedro Zuazua‐Villar, Zuza Kozik, Felix M. Dobbs, Patrick van Eijk et al. · 2026 · Genome biology
  46. TransG4: an interpretable deep-learning approach for sequence-based G-quadruplex prediction.
    Yong-Na Yuan, Yaojie Tian, Zhenyu Liu, Jun Ma · 2026 · Physical Chemistry, Chemical Physics - PCCP
  47. Endogenous promoter G-quadruplexes scaffold apurinic/apyrimidinic endonuclease (APE1) to drive gene expression
    Ying-Ling Chen, Bhopal C. Mohapatra, Suravi Pramanik, Mason W. Tarpley, Achyuth Kalluchi, Sutapa Ray, Kyle Hewitt, M. J. Rowley, V. Band, K. Bhakat · 2026 · Nucleic Acids Research
  48. A benzothiazolium salt fluorophore for topology-specific discrimination of non-B DNA structures
    Ya-Wen Hou, Ruofeng Xu, Yu-Jiao Hou, Yi Du, Ke-Yi Gao, Jianlei Shen, Bin Chen · 2026 · Results in Chemistry
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  50. Dissecting the Binding Interactions of the Chromatin Remodeler SMARCA4 with G‑Quadruplex DNA
    S. Madden, D. Tannahill, Shankar Balasubramanian · 2026 · Biochemistry
  51. Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS
    Gui-Xue Tang, Jia-Tong Yan, Mao-Lin Li, Cui Zhou, Jian Wang, Shuo-Bin Chen, Zhi-Shu Huang, Jia-Heng Tan · 2026 · Advancement of science
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    Tingyu Jing, Lvyao Yang, Zi-Yi Yuan, Gui-Xia Ling, Peng Zhang · 2026 · Talanta: The International Journal of Pure and Applied Analytical Chemistry
  53. Photoclick chemistry led to the identification of HELLS as a helicase for DNA G-quadruplexes
    Zi Gao, Yiewoon Chong, Xiao-Mei He, Jun Yuan, Yin-Sheng Wang · 2026 · Nucleic Acids Research
  54. BMI1 represses G-quadruplex DNA formation to maintain genomic stability during replication
    Roy Hanna, Éric Deneault, Gilbert Bernier · 2026 · Journal of Biological Chemistry
  55. In silico mapping of non-canonical DNA structures across the human ribosomal DNA locus
    Jyoti D Adala, Bruce A. Knutson · 2025 · G3 Genes Genomes Genetics
  56. Low ionic strength enhances the fluorescence of Thioflavin T bound to parallel G-quadruplexes.
    Tao Li, Zhi-Hao Li, Bang-Shun He, Xiaolin He, Jinghan Tian, Zhe-Yu Li, Na Du, Guojun Zhang, Yunhuang Yang, Ying Li · 2025 · Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy
  57. Auto-luminescence study of thermal unfolding of DNA G-quadruplexes
    V. Kudrya, I. Dubey, V. Negrutska, A. Naumenko · 2025 · RSC Advances
  58. Expression of G-quadruplex coordinates BRCA1, CDH1, and RASSF1 via DNA methylation in mouse breast cancer cells.
    Xinchen Zhou, Zhuo Jin, Xintong Zhan, Shuhui Yang, Yang Jiang, Helin Wang, Zhuo Zhang, Shuhan Dong, Wei Xia, Limei Liu · 2025 · Epigenomics
  59. Multiformity of a G/C Rich Segment at the Promoter-UTR Intersection of RAP2C Gene: Structural Validation by Circular Dichroism
    Anju Singh, S. Kukreti · 2025 · ACS Omega
  60. DNA–Gold Nanoparticle Dumbbells: Synthesis and Nanoscale Characterization
    Esraa Hijaze, Liat Katrivas, Zakhar V. Reveguk, S. Richter, Alexander B. Kotlyar · 2025 · Nanomaterials
  61. Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life
    Z. Aktary, Kate Sorg, Anne Cucchiarini, Guglielmo Vesco, Dorian Noury, Rongxin Zhang, Thomas Jourdain, Daniela Verga, Pierre Mahou, Nicolas Olivier et al. · 2025 · bioRxiv
  62. Fluorescence Light-Up of G4 DNA Structures Using Azlactone-Based Probes.
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  63. The interactions of 9-methoxyluminarine with Bcl-2 G-quadruplex
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  64. Rapid G4 Ligand Screening Through Spectral Changes Using HT-SRCD with Minimal Material
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  65. Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites
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  66. Insight into the epigenetic regulation of gene expression in the bloodstream and procyclic forms of Trypanosoma brucei through the involvement of G-quadruplexes
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  67. Discovery of a Novel and Potent MET Transcription Inhibitor Targeting Promoter G-Quadruplex for the Treatment of NSCLC.
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  68. Microperoxidase-11-induced reconfiguration of G-quadruplex nanostructures.
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  69. Mechanistic insights into the G-quadruplex-duplex equilibrium in the c-kit promoter: Role of ions and flanking sequences
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  70. Decoding G-Quadruplexes Sequence in Vitis vinifera: Regulatory Region Enrichment, Drought Stress Adaptation, and Sugar–Acid Metabolism Modulation
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  71. Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides
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  72. Polyphosphate as a novel regulator of super-enhancer complexes: disruption of phase separation and gene expression
    Zhiyun Yang, Zong-Chao Jia · 2024 · bioRxiv
  73. Roles of Loop Region in Folding Kinetics and Transcription Inhibition of DNA G-Quadruplexes.
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  74. A correlation of polymorphic G-quadruplex formation in vitro and in the lysosomes of live cancer cells.
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  75. In Silico Design of a Solution-Gated Graphene Transistor Sensor for the Efficient Detection of Guanine Quadruplexes
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  76. Combinatorial Anti-Cancer Effect of Polypurine Reverse Hoogsteen Hairpins against KRAS and MYC Targeting in Prostate and Pancreatic Cancer Cell Lines
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  77. G-Quadruplex DNA as a Macromolecular Target for Semi-Synthetic Isoflavones Bearing B-Ring Tosylation
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  78. The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast Saccharomyces cerevisiae
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  79. Stimulation of ATP hydrolysis by ssDNA provides the necessary mechanochemical energy for G4 unfolding.
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  80. Post- and Pre-Radiolabeling Assays for anti Thymidine Cyclobutane Dimers as Intrinsic Photoprobes of Various Types of G-Quadruplexes, Reverse Hoogsteen Hairpins, and Other Non-B DNA Structures
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  81. The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast S. cerevisiae
    Libuše Kratochvilová, Matúš Vojsovič, N. Valková, Lucie Šislerová, Zeinab El Rashed, A. Inga, P. Monti, V. Brázda · 2023 · bioRxiv
  82. Asymmetric triplex metallohelices stabilise DNA G-quadruplexes in promoter oncogene sequences and efficiently reduce their expression in cancer cells
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  83. From Peptide Nucleic Acids to Supramolecular Structures of Nucleic Acid Derivatives
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  84. Human Virus Genomes Are Enriched in Conserved Adenine/Thymine/Uracil Multiple Tracts That Pause Polymerase Progression
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  85. The Pressure Dependence of the Stability of the G-quadruplex Formed by d(TGGGGT)
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  86. Current Analytical Strategies in Studying Chromatin-Associated-Proteome (Chromatome)
    N. Khan, S. Shahid, A. Asif · 2021 · Molecules
  87. Disclosing the actual efficiency of G-quadruplex-DNA–disrupting small molecules
    Jérémie Mitteaux, Pauline Lejault, Marc Pirrotta, F. Wojciechowski, Alexandra Joubert, N. Desbois, C. Gros, R. Hudson, J. Boulé, A. Granzhan et al. · 2020 · bioRxiv
  88. Effect of interaction between loop bases and ions on stability of G-quadruplex DNA
    Han-Zhen Qiao, Yuan-Yan Wu, Yusong Tu, Cong-Min Ji · 2020 · Chinese Physics B
  89. Ligand Selectivity by Inserting GCGC-tetrads Into G-quadruplex Structures.
    Yan-Wei Cao, Lu-Yan Yang, Pi Ding, Wenjing Li, R. Pei · 2020 · Chemistry
  90. A dual-app nucleoside probe reports G-quadruplex formation and ligand binding in the long terminal repeat of HIV-1 proviral genome
    Vyankat A. Sontakke, Seergazhi G. Srivatsan · 2020 · Bioorganic & Medicinal Chemistry Letters
  91. Screening of G-quadruplex DNA ligands by fluorescence detection of peptide displacement
    Valentina Arciuolo, Simona Marzano, Rossella Buono, Nicola Grasso, Anna Di Porzio, Antonio Randazzo, Bruno Pagano, J. Amato · 2025 · European Journal of Medicinal Chemistry Reports
  92. Structure-activity relationship of berberine and G4 DNA reveals aromaticity’s effect on binding affinity
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  93. Non-standard and higher-order DNA structures: DNA–DNA recognition
    Stephen Neidle, Mark R. Sanderson · 2021 · Elsevier eBooks
  94. Synthesis of novel 2-indolone-aspirin hybrid molecules and their interaction mechanism with calf thymus DNA
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  95. Genome-wide distribution and putative regulatory roles of G-quadruplex motifs in oral bacteria
    Yizhou Wang, 傅宗云, Pengcheng Gao, Yaozhong Chen · 2026 · Frontiers in Genetics
  96. Thermodynamic and Structural Basis of Selectivity in the Binding of Tetrapentylammonium to G-Quadruplexes
    Xuan Li, D. Dubins, James W. Wells, T. Chalikian · 2026 · Journal of Physical Chemistry B
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    Dengshuai Wei, Yijia Chen, Jiaqian Xu, Guangyu Zhu · 2026 · Journal of the American Chemical Society
  98. G-quadruplex structures affect the immune response to bacterial infection in mouse macrophages
    Philipp Schult, Melanie A. Kastl, Jennifer Szlapa, Konstantinos Symeonidis, Salie Maasewerd, B. Franklin, Alea Radcke, Stefan Juranek, Z. Abdullah, K. Paeschke · 2026 · Nature Communications
  99. A promoter G-quadruplex recruits Hrb27C to regulate NEMO and immune defense against Lyme disease pathogens in the deer tick.
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